EC Explorer
[browse EC tree] - [search]
EC 4.2.1.139 Details
show Brenda entryEC number
4.2.1.139
Accepted name
pterocarpan synthase
Reaction
a (4R)-4,2′-dihydroxyisoflavan = a pterocarpan + H2O
Other name(s)
medicarpin synthase,
medicarpan synthase,
7,2′-dihydroxy-4′-methoxyisoflavanol dehydratase,
2′,7-dihydroxy-4′-methoxyisoflavanol dehydratase,
DMI dehydratase,
DMID,
2′-hydroxyisoflavanol 4,2′-dehydratase,
PTS (gene name),
4′-methoxyisoflavan-2′,4,7-triol hydro-lyase [(–)-medicarpin-forming]
Systematic name
(4R)-4,2′-dihydroxyisoflavan hydro-lyase (pterocarpan-forming)
Comment
The enzyme catalyses the formation of the additional ring in pterocarpan, the basic structure of phytoalexins produced by leguminous plants, including (–)-medicarpin, (+)-medicarpin, (–)-maackiain and (+)-maackiain. The enzyme requires that the hydroxyl group at C-4 of the substrate is in the (4R) configuration. The configuration of the hydrogen atom at C-3 determines whether the pterocarpan is the (+)- or (–)-enantiomer. The enzyme contains amino acid motifs characteristic of dirigent proteins.
History
created 2013, modified 2019
back to topEC Tree
1 Oxidoreductases
4 Lyases
4.2.1.13 created 1961, deleted 2001 4.2.1.14 created 1961, deleted 2001 4.2.1.15 created 1961, deleted 1972 4.2.1.16 created 1961, deleted 2001 4.2.1.21 created 1961, deleted 1964 4.2.1.23 created 1961, deleted 1972 4.2.1.26 created 1965, deleted 2002 4.2.1.29 created 1965, deleted 2004 4.2.1.37 created 1972, deleted 1992 4.2.1.38 created 1972, deleted 2001 4.2.1.63 created 1972, deleted 1978 4.2.1.64 created 1972, deleted 1978 4.2.1.71 created 1978, modified 1989, modified 2000, deleted 2004 4.2.1.72 created 1978, deleted 2000 4.2.1.86 created 1989, deleted 2004 4.2.1.102 created 2001, deleted 2001
