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EC 3.2.2.23 Details

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EC number

3.2.2.23

Accepted name

DNA-formamidopyrimidine glycosylase

Reaction

Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine

Other name(s)

Fapy-DNA glycosylase, deoxyribonucleate glycosidase, 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase, 2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase, formamidopyrimidine-DNA glycosylase, DNA-formamidopyrimidine glycosidase, Fpg protein

Systematic name

DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing]

CAS registry number

78783-53-6

Comment

May play a significant role in processes leading to recovery from mutagenesis and/or cell death by alkylating agents. Also involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA.

History

created 1990, modified 2000

EC Tree

1 Oxidoreductases

2 Transferases

3 Hydrolases

3.1 Acting on ester bonds

3.2 Glycosylases

3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

3.2.2 Hydrolysing N-glycosyl compounds

3.2.2.1 purine nucleosidase

3.2.2.2 inosine nucleosidase

3.2.2.3 uridine nucleosidase

3.2.2.4 AMP nucleosidase

3.2.2.5 NAD⁺ glycohydrolase

3.2.2.6 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase

3.2.2.7 adenosine nucleosidase

3.2.2.8 ribosylpyrimidine nucleosidase

3.2.2.9 adenosylhomocysteine nucleosidase

3.2.2.10 pyrimidine-5′-nucleotide nucleosidase

3.2.2.11 β-aspartyl-N-acetylglucosaminidase

3.2.2.12 inosinate nucleosidase

3.2.2.13 1-methyladenosine nucleosidase

3.2.2.14 NMN nucleosidase

3.2.2.15 DNA-deoxyinosine glycosylase

3.2.2.16 methylthioadenosine nucleosidase

3.2.2.17 deoxyribodipyrimidine endonucleosidase

3.2.2.18 created 1984, deleted 1989

3.2.2.19 [protein ADP-ribosylarginine] hydrolase

3.2.2.20 DNA-3-methyladenine glycosylase I

3.2.2.21 DNA-3-methyladenine glycosylase II

3.2.2.22 rRNA N-glycosylase

3.2.2.23 DNA-formamidopyrimidine glycosylase

3.2.2.24 ADP-ribosyl-[dinitrogen reductase] hydrolase

3.2.2.25 N-methyl nucleosidase

3.2.2.26 futalosine hydrolase

3.2.2.27 uracil-DNA glycosylase

3.2.2.28 double-stranded uracil-DNA glycosylase

3.2.2.29 thymine-DNA glycosylase

3.2.2.30 aminodeoxyfutalosine nucleosidase

3.2.2.31 adenine glycosylase

3.2.3 Hydrolysing S-glycosyl compounds (deleted sub-subclass)

3.3 Acting on ether bonds

3.4 Acting on peptide bonds (peptidases)

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.6 Acting on acid anhydrides

3.7 Acting on carbon-carbon bonds

3.7.1 In ketonic substances

3.8 Acting on halide bonds

3.9 Acting on phosphorus-nitrogen bonds

3.10 Acting on sulfur-nitrogen bonds

3.11 Acting on carbon-phosphorus bonds

3.12 Acting on sulfur-sulfur bonds

3.13 Acting on carbon-sulfur bonds