2.4.99.20: 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase
This is an abbreviated version!
For detailed information about 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase, go to the full flat file.
Reaction
Synonyms
2'-phospho-cyclic-ADP-ribose transferase, ADP-ribosyl cyclase 1, ADPRC 1, BST1, CD38, diphosphopyridine nucleosidase
ECTree
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Inhibitors
Inhibitors on EC 2.4.99.20 - 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase
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nicotinamide
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inhibition of the cyclization reaction and is 30fold more potent at suppressing the base-exchange reaction. Inhibition is not via a competition with the nicotinic acid-binding site
additional information
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the cyclization reaction is insensitive to free Ca2+ concentration in the range 20 nM100 microM. Mg2+ is not inhibitory
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