2.4.1.131: GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase
This is an abbreviated version!
For detailed information about GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase, go to the full flat file.
Word Map on EC 2.4.1.131
-
2.4.1.131
-
lipid-linked
-
n-glycosylation
-
n-linked
-
glycosyltransferase
-
dolichol-linked
-
asparagine-linked
-
man5glcnac2-pp-dolichol
-
alpha1,2-linked
-
single-subunit
-
oligosaccharyltransferase
-
man5glcnac2-pp-dol
-
microcephaly
- 2.4.1.131
-
lipid-linked
-
n-glycosylation
-
n-linked
- glycosyltransferase
-
dolichol-linked
-
asparagine-linked
-
man5glcnac2-pp-dolichol
-
alpha1,2-linked
-
single-subunit
-
oligosaccharyltransferase
-
man5glcnac2-pp-dol
-
microcephaly
Reaction
2 GDP-alpha-D-mannose + = 2 GDP +
Synonyms
Alg11, Alg2 mannosyltransferase, At2G40190, galactomannan deficiency protein 3, GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase, GDP-mannose-oligosaccharide-lipid mannosyltransferase, gmd3, guanosine diphosphomannose-oligosaccharide-lipid mannosyltransferase, hALG11, LEW3, mannosyltransferase, guanosine diphosphomannose-oligosaccharide-lipid, oligosaccharide-lipid mannosyltransferase
ECTree
Advanced search results
Engineering
Engineering on EC 2.4.1.131 - GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
L86P
mutant enzyme does not complement the growth deffect of the mutant strain DELTAalgg3 (Saccharomyces cerevisiae)
L86S
mutant enzyme slightly complements the growth deffect of the mutant strain DELTAalgg3 (Saccharomyces cerevisiae)
E405/H406A
double mutant no longer supports growth, the loss of activity is not caused by a failure of Alg11 expression
E405A
E405A/E413
double mutant no longer supports growth, the loss of activity is not caused by a failure of Alg11 expression
E413A
F407A
mutation is not detrimental for growth, impairment of glycosylation of the vacuolar model glycoproteincarboxypeptidase Y
G84A
mutation has no effect on growth and glycosylation of the vacuolar model glycoproteincarboxypeptidase Y
G84P
mutation reduces growth and glycosylation of the vacuolar model glycoproteincarboxypeptidase Y
G85A
mutation has no effect on growth and glycosylation of the vacuolar model glycoproteincarboxypeptidase Y
G85P
mutation reduces growth and glycosylation of the vacuolar model glycoproteincarboxypeptidase Y
G87A
mutation has no effect on growth and glycosylation of the vacuolar model glycoproteincarboxypeptidase Y
G87P
mutation reduces growth and glycosylation of the vacuolar model glycoproteincarboxypeptidase Y
H406A
mutation is not detrimental for growth, impairment of glycosylation of the vacuolar model glycoproteincarboxypeptidase Y
additional information
mutation causes an underglycosylation of the vacuolar model glycoproteincarboxypeptidase Y
E405A
mutation causes nearly complete abrogation of product formation
activity is indistinguishable from that of the wild-type under comparable conditions
chemo-enzymatic synthesis of lipid-linked GlcNAc2Man5 oligosaccharides using recombinant Alg1 (from yeast, EC 2.4.1.142), Alg2 (from human, EC 2.4.1.257), and Alg11 proteins, chemo-enzymatic synthesis strategy to extend the glycan moiety of synthetic LLO analogues to Dol-PP-GlcNAc2Man5, method, overview
additional information
-
chemo-enzymatic synthesis of lipid-linked GlcNAc2Man5 oligosaccharides using recombinant Alg1 (from yeast, EC 2.4.1.142), Alg2 (from human, EC 2.4.1.257), and Alg11 proteins, chemo-enzymatic synthesis strategy to extend the glycan moiety of synthetic LLO analogues to Dol-PP-GlcNAc2Man5, method, overview
-