2.3.1.211: bisdemethoxycurcumin synthase
This is an abbreviated version!
For detailed information about bisdemethoxycurcumin synthase, go to the full flat file.
Word Map on EC 2.3.1.211
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2.3.1.211
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curcuminoids
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oryza
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polyketide
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sativa
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synthesis
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turmeric
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starter
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curcuma
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longa
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thioester
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diarylheptanoids
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gingerol
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4-coumaroyl-coas
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phenylpropanoids
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rhizome
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hepatoprotective
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erythrorhizon
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cinnamic
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diketide
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one-pot
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shoot
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ammonia-lyase
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4-coumarate
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plant-specific
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lithospermum
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4-coumarate:coa
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analysis
- 2.3.1.211
-
curcuminoids
- oryza
- polyketide
- sativa
- synthesis
- turmeric
-
starter
-
curcuma
- longa
- thioester
-
diarylheptanoids
- gingerol
- 4-coumaroyl-coas
-
phenylpropanoids
- rhizome
-
hepatoprotective
- erythrorhizon
-
cinnamic
-
diketide
-
one-pot
- shoot
-
ammonia-lyase
- 4-coumarate
-
plant-specific
-
lithospermum
-
4-coumarate:coa
- analysis
Reaction
2 4-coumaroyl-CoA + + = 3 CoA + + 2 CO2
Synonyms
ClPKS10, curcumin synthase, curcuminoid synthase, CUS, Os07g0271500, OsCUS
ECTree
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Engineering
Engineering on EC 2.3.1.211 - bisdemethoxycurcumin synthase
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additional information
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construction of an artificial curcuminoid biosynthetic pathway, including reactions of phenylalanine ammonia-lyase from the yeast Rhodotorula rubra, 4-coumarate:CoA ligase from Lithospermum erythrorhizon and curcuminoid synthase from Oryza sativa in Escherichia coli for the production of curcuminoids. Cultivation of the recombinant Escherichia coli cells in the presence of tyrosine or phenylalanine, or both, leads to production of bisdemethoxycurcumin, dicinnamoylmethane and cinnamoyl-4-coumaroylmethane, overview. Another Escherichia coli system carrying the 4-coumarate:CoA ligase and the CUS genes is also useful for high-yield production of curcuminoids from exogenously supplemented phenylpropanoid acids 4-coumaric acid, cinnamic acid and ferulic acid
additional information
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production of several dehydrogingerdione (a gingerol derivative) analogues from a recombinant Escherichia coli strain in which an artificial biosynthesis pathway for dehydrogingerdione is reconstructed that is not based on the original biosynthesis pathway of gingerol derivatives in plants. The system consists of a 4-coumarate:CoA ligase from Lithospermum erythrorhizon, a fatty acid CoA ligase from Oryza sativa, a beta-oxidation system from Saccharomyces cerevisiae, and a curcuminoid synthase from Oryza sativa