2.1.1.B109: tRNA (cytosine32-N3)-methyltransferase
This is an abbreviated version!
For detailed information about tRNA (cytosine32-N3)-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.B109
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2.1.1.B109
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actin
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3-methylcytidine
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trnas
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actin-binding
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lifeact
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retrograde
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cables
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trnathr
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s-adenosylmethionine
- 2.1.1.B109
- actin
-
3-methylcytidine
- trnas
-
actin-binding
-
lifeact
-
retrograde
- cables
- trnathr
- s-adenosylmethionine
Reaction
Synonyms
Abp140p, methyltransferase-like protein 2B, METTL2B, Trm140p
ECTree
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General Information
General Information on EC 2.1.1.B109 - tRNA (cytosine32-N3)-methyltransferase
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malfunction
physiological function
additional information
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deletion of the actin-binding sequence in ABP140 does not affect m3C formation. The yor240wDELTA strain, lacking the half of gene ABP140, hatbors tRNAs Ser and Thr that are not m3C methylated, mass spectrometric aanalysis
malfunction
specific reduction of m3C formation in HeLa cells by siRNA-mediated knockdown of the human orthologue of TRM14
malfunction
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deletion of the actin-binding sequence in ABP140 does not affect m3C formation. The yor240wDELTA strain, lacking the half of gene ABP140, hatbors tRNAs Ser and Thr that are not m3C methylated, mass spectrometric aanalysis
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methyl modification of m3C32 might modulate accurate codon recognition at the A-site and the proper ribosomal positioning at the P-site. Abp140p interacts with filamentous actin and has an activity to cross-link F-actin into a bundle in vitro. In the cell, Abp140p colocalizes with cortical actin patches and cytoplasmic actin filaments, but it is not required for cell growth or organization of F-actin
physiological function
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methyl modification of m3C32 might modulate accurate codon recognition at the A-site and the proper ribosomal positioning at the P-site. Abp140p interacts with filamentous actin and has an activity to cross-link F-actin into a bundle in vitro. In the cell, Abp140p colocalizes with cortical actin patches and cytoplasmic actin filaments, but it is not required for cell growth or organization of F-actin
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some partner proteins of METTL2B might be required to reconstitute m3C formation in tRNAs
additional information
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some partner proteins of METTL2B might be required to reconstitute m3C formation in tRNAs
additional information
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subcellular localization of ABP140 to actin filaments is not involved in tRNA modification
additional information
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subcellular localization of ABP140 to actin filaments is not involved in tRNA modification
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