2.1.1.372: [histone H4]-lysine20 N-trimethyltransferase

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For detailed information about [histone H4]-lysine20 N-trimethyltransferase, go to the full flat file.

Reaction

3 S-adenosyl-L-methionine +

Synonyms

NSD3, SET9

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.372 [histone H4]-lysine20 N-trimethyltransferase

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Results	in table
1942	AA Sequence
1	Cloned(Commentary)
1	Crystallization (Commentary)
2	General Information
3	Organism
2	Pathway
4	Reaction
3	Reference
7	Substrates and Products (Substrate)
4	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 2.1.1.372 - [histone H4]-lysine20 N-trimethyltransferase

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SYSTEMATIC NAME

IUBMB Comments

S-adenosyl-L-methionine:[histone H4]-L-lysine20 N6-trimethyltransferase

The enzyme, characterized from the fission yeast Schizosaccharomyces pombe, catalyses three successive methylations of the L-lysine-20 residue of histone H4 (H4K20), forming the trimethylated form. The methylation of this site is apparently not involved in the regulation of gene expression or heterochromatin function but participates in DNA damage response. cf. EC 2.1.1.361, [histone H4]-lysine20 N-methyltransferase, and EC 2.1.1.362, [histone H4]-N-methyl-L-lysine20 N-methyltransferase.