1.14.19.B10: indole 3-halogenase

This is an abbreviated version!
For detailed information about indole 3-halogenase, go to the full flat file.

Reaction

+ 2 H2O

Synonyms

brvH, FHal, flavin-dependent halogenase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.19 With oxidation of a pair of donors resulting in the reduction of O₂ to two molecules of water

1.14.19.B10 indole 3-halogenase

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Results	in table
1	AA Sequence
1	Cloned(Commentary)
2	Cofactor
1	Crystallization (Commentary)
1	Organism
1	Purification (Commentary)
1	Reaction
1	Reference
3	Substrates and Products (Substrate)
3	Synonyms
1	Systematic Name

Substrates Products

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Substrates Products on EC 1.14.19.B10 - indole 3-halogenase

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indole + FADH2 + bromide + O2 + H+

3-bromoindole + FAD + 2 H2O

Brevundimonas sp. BAL3

B4WBL8

758167

indole + FADH2 + chloride + O2 + H+

3-chloroindole + FAD + 2 H2O

Brevundimonas sp. BAL3

B4WBL8

low activity

758167

additional information

Brevundimonas sp. BAL3

B4WBL8

the enzyme prefers bromide to chloride as halide source. The enzyme shows no halogenation of tryptophan, neither in presence of chloride nor in presence of bromide and has no activity with 5-hydroxytryptohan, tryptophol, indole-3-propionic acid, and indole-3-acetonitrile

758167