Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.14.15.33: pikromycin synthase

This is an abbreviated version!
For detailed information about pikromycin synthase, go to the full flat file.

Word Map on EC 1.14.15.33

Reaction

10-deoxymethymycin
+ 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ +
O2
=
methymycin
 + 2 oxidized ferredoxin [iron-sulfur] cluster +
H2O

Synonyms

CYP107L1, CYP107L2, EC 1.14.13.185, erythromycin C-12 hydroxylase, PikC

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.15.33 pikromycin synthase

Systematic Name

Systematic Name on EC 1.14.15.33 - pikromycin synthase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SYSTEMATIC NAME
IUBMB Comments
narbomycin,reduced ferredoxin:oxygen oxidoreductase (pikromycin-forming)
A cytochrome P-450 (heme-thiolate) protein. Involved in the biosynthesis of a number of bacterial macrolide antibiotics containing a desosamine glycoside unit. With narbomycin it hydroxylates at either C-12 to give pikromycin or C-14 to give neopikromycin or both positions to give narvopikromycin. With 10-deoxymethymycin it hydroxylates at either C-10 to give methymycin or C-12 to give neomethymycin or both positions to give novamethymycin.