1.14.14.B10: heme oxygenase (hematinic acid-producing)
This is an abbreviated version!
For detailed information about heme oxygenase (hematinic acid-producing), go to the full flat file.
Reaction
Synonyms
ChuS
ECTree
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Substrates Products
Substrates Products on EC 1.14.14.B10 - heme oxygenase (hematinic acid-producing)
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REACTION DIAGRAM
protoporphyrin IX + ascorbate + O2
hematinic acid + a tripyrrole + Fe3+
cosubstrate is hydrogen peroxide that is formed in solution in the presence of ascorbate and O2
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additional information
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enzyme binds and degrades heme in a reaction that releases carbon monoxide. Initial intermediates of the reaction of ChuS with hydrogen peroxide, i.e. a ferrous keto pi neutral radical and ferric verdoheme, are in common with heme oxygenases, while a further reaction step, involving the cleavage of the porphyrin ring at adjacent meso-carbons, results in the release of hematinic acid, a tripyrrole product and non-heme iron in the ferric oxidation state
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