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EC Number
Protein Variants
Commentary
Reference
3.4.22.36
A329T
a procaspase-1 variant with decreased enzymatic activity
732269
3.4.22.36
A329T
the mutant demonstrates absent enzymatic and interleukin-1beta releasing activity in vitro
731897
3.4.22.36
C136S
the mutant enzyme shows decreased activity compared to the wild-type enzyme
700365
3.4.22.36
C169S
the mutant enzyme shows decreased activity compared to the wild-type enzyme
700365
3.4.22.36
C244S
the mutant enzyme shows decreased activity compared to the wild-type enzyme
700365
3.4.22.36
C270S
the mutant enzyme shows decreased activity compared to the wild-type enzyme
700365
3.4.22.36
C284A
inactive
732557
3.4.22.36
C285A
a procaspase-1 variant with decreased enzymatic activity showing about 3.5fold increased nuclear factor-kappaB activation compared to the wild type enzyme
732269
3.4.22.36
C285A
active site null mutant
732127
3.4.22.36
C285A
inactive
731897
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