EC Number   |
Application |
Reference |
|---|
    2.7.8.7 | analysis |
enzyme can be utilized in an assay for apo-ACP in biological material |
486864 |
| 2.7.8.7 | analysis |
method for the generation of crypto-AcpM loaded with a solvatochromic probe 7-nitrobenz-2-oxa-1,3-diazol-4-yl, which is linked to the 4'-phosphopantetheine (Ppant) prosthetic group of AcpM by Sfp. The crypto-AcpM is employed to explore the elusive dynamics of Ppant arm in AcpM |
-, 761087 |
| 2.7.8.7 | biotechnology |
biotechnological de novo production of m-cresol from sugar in complex yeast extract-peptone medium with the yeast Saccharomyces cerevisiae. A heterologous pathway based on the decarboxylation of the polyketide 6-methylsalicylic acid is introduced into a CEN.PK yeast strain. Overexpression of codon-optimized 6-methylsalicylic acid synthase from Penicillium patulum together with activating phosphopantetheinyl transferase npgA from Aspergillus nidulans results in up to 367 mg/l 6-methylsalicylic acid production. Additional genomic integration of the genes have a strongly promoting effect and 6-methylsalicylic acid titers reach more than 2 g/l. Simultaneous expression of 6-methylsalicylic acid decarboxylase patG from Aspergillus clavatus leads to the complete conversion of 6-methylsalicylic acid and production of up to 589 mg/L m-cresol |
757577 |
| 2.7.8.7 | biotechnology |
identification of short peptide tags of 12 residues as efficient substrate for site-specific protein labeling catalyzed by enzyme |
671027 |
| 2.7.8.7 | biotechnology |
mutant ACPs will be valuable in dissecting the structure-function relationships of ACP and its participation in synthesis and regulation of fatty acid, phospholipids, and other products of medical and biotechnological importance |
645410 |
| 2.7.8.7 | drug development |
the enzyme is a broad-spectrum target for design of antifungal drugs |
739435 |
| 2.7.8.7 | drug development |
the human pathogen Mycobacterium tuberculosis PPTases are attractive drug targets |
-, 738932 |
| 2.7.8.7 | medicine |
enzyme plays an important role in bacterial fatty acid and lipid biosynthesis, making it an attractive target for therapeutic intervention, drug design by identifying inhibitors with potential antibacterial activity |
645406 |
| 2.7.8.7 | medicine |
isoform PptT is a target for anti-tuberculosis drugs |
-, 723610 |
| 2.7.8.7 | medicine |
producer of the hybrid peptide-polyketide antitumor drug bleomycin |
-, 645412 |
