Reference on EC 3.2.2.27 - uracil-DNA glycosylase and Organism(s) Homo sapiens
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Masaoka,A.; Matsubara, M.; Hasegawa, R.; Tanaka,T.; Kurisu,S.; Terato,H.; Ohyama,Y.; Karino, N.; Matsuda,A
Ide, H.: Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions
Biochemistry
42
5003-5012
2003
Homo sapiens (Q53HV7), Homo sapiens, Rattus norvegicus (Q811Q1)
Guo, C.; Zhang, X.; Fink, S.P.; Platzer, P.; Wilson, K.; Willson, J.K.; Wang, Z.; Markowitz, S.D.
Ugene, a newly identified protein that is commonly overexpressed in cancer, and that binds uracil DNA-glycosylase
Cancer Res.
68
6118-6126
2008
Homo sapiens (P22674)
Haushalter, K.A
Stukenberg, P.T.; Kirschner, M.W.; Verdine, G.L.: Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors
Curr. Biol.
9
174-185
1999
Xenopus laevis, Homo sapiens (Q53HV7), Homo sapiens
Chen, C.-Y.; Mosbaugh, D.W.; Bennett, S.E.
Mutations at arginine 276 transform human uracil-DNAglycosylase into a single-stranded DNA-specific uracil-DNA glycosylase
DNA Repair
4
793-805
2005
Homo sapiens (P13051), Homo sapiens
Boorstein, R.J.; Cumming, A.; Marenstein, D.R.; Chan, M.K.; Ma, Y.; Neubert, T.A.; Brown, S.M.; Teebor, G.W.
Definitive identification of mammalian 5-hydroxymethyluracil DNA N-glycosylase activity as SMUG1
J. Biol. Chem.
276
41991-41997
2001
Homo sapiens (Q53HV7), Homo sapiens, Bos taurus (Q59T47), Bos taurus
Kavli, B.; Sundheim, O.; Akbari, M.; Otterlei, M.; Nilsen, H.; Skorpen, F.; Aas, P.A.; Hagen, L.; Krokan, H.E.; Slupphaug, G.
hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup
J. Biol. Chem.
277
39926-39936
2002
Homo sapiens, Homo sapiens (P22674)
Darwanto, A.; Theruvathu, J.A.; Sowers, J.L.; Rogstad, D.K.; Pascal, T.; Goddard III, W.; Sowers, L.C.
Mechanisms of base selection by human single-stranded selective monofunctional uracil-DNA glycosylase
J. Biol. Chem.
284
15835-15846
2009
Homo sapiens (Q53HV7), Homo sapiens
Mi, R.; Dong, L.; Kaulgud, T.; Hackett, K.W.; Dominy, B.N.; Cao, W.
Insights from xanthine and uracil DNA glycosylase activities of bacterial and human SMUG1: switching SMUG1 to UDG
J. Mol. Biol.
385
761-778
2009
Geobacter metallireducens (Q39ZI0), Geobacter metallireducens, Homo sapiens (Q53HV7), Homo sapiens, Geobacter metallireducens GS-15 / ATCC 53774 / DSM 7210 (Q39ZI0)
Priet, S.; Gros, N.; Navarro, J.-M.; Boretto, J.I.; Canard, B.; Querat, G.; Sire, J.
HIV-1-associated uracil DNA glycosylase activity controls dUTP misincorporation in viral DNA and is essential to the HIV-1 life cycle
Mol. Cell
17
479-490
2005
Homo sapiens (P22674)
Pearl, J.H.
Structure and function in the uracil-DNA glycosylase superfamily
Mutat. Res.
460
165-181
2000
Escherichia coli, Homo sapiens, Human alphaherpesvirus 1 (P10186)
Parikh, S.S.; Putnam, C.D.; Tainer, J.A.
Lessons learned from structural results on uracil-DNA glycosylase
Mutat. Res.
460
183-199
2000
Homo sapiens
Matsubara, M.; Tanaka, T.; Terato, H.; Ohmae, E.; Izumi, S.; Katayanagi, K.; Ide, H.
Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase
Nucleic Acids Res.
32
5291-5302
2004
Homo sapiens (Q53HV7), Homo sapiens
Aziz, M.A.; Schupp, J.E.; Kinsella, T.J.
Modulation of the activity of methyl binding domain protein 4 (MBD4/MED1) while processing iododeoxyuridine generated DNA mispairs
Cancer Biol. Ther.
8
1156-1163
2009
Homo sapiens
Ma, K.W.; Au, S.W.; Waye, M.M.
Over-expression of SUMO-1 induces the up-regulation of heterogeneous nuclear ribonucleoprotein A2/B1 isoform B1 (hnRNP A2/B1 isoform B1) and uracil DNA glycosylase (UDG) in HepG2 cells
Cell Biochem. Funct.
27
228-237
2009
Homo sapiens
Knaevelsrud, I.; Slupphaug, G.; Leiros, I.; Matsuda, A.; Ruoff, P.; Bjelland, S.
Opposite-base dependent excision of 5-formyluracil from DNA by hSMUG1
Int. J. Radiat. Biol.
85
413-420
2009
Homo sapiens
Huang, H.; Stivers, J.T.; Greenberg, M.M.
Competitive inhibition of uracil DNA glycosylase by a modified nucleotide whose triphosphate is a substrate for DNA polymerase
J. Am. Chem. Soc.
131
1344-1345
2009
Escherichia coli, Homo sapiens (P13051)
Jones, K.L.; Roche, M.; Gantier, M.P.; Begum, N.A.; Honjo, T.; Caradonna, S.; Williams, B.R.; Mak, J.
X4 and R5 HIV-1 have distinct post-entry requirements for uracil DNA glycosylase during infection of primary cells
J. Biol. Chem.
285
18603-18614
2010
Homo sapiens
Zharkov, D.O.; Mechetin, G.V.; Nevinsky, G.A.
Uracil-DNA glycosylase: Structural, thermodynamic and kinetic aspects of lesion search and recognition
Mutat. Res.
685
11-20
2010
Escherichia coli, Homo sapiens
Fenard, D.; Houzet, L.; Bernard, E.; Tupin, A.; Brun, S.; Mougel, M.; Devaux, C.; Chazal, N.; Briant, L.
Uracil DNA glycosylase 2 negatively regulates HIV-1 LTR transcription
Nucleic Acids Res.
37
6008-6018
2009
Homo sapiens
Visnes, T.; Doseth, B.; Pettersen, H.; Hagen, L.; Sousa, M.; Akbari, M.; Otterlei, M.; Kavli, B.; Slupphaug, G.; Krokan, H.
Uracil in DNA and its processing by different DNA glycosylases
Philos. Trans. R. Soc. Lond. B Biol. Sci.
364
563-568
2009
Homo sapiens, Mus musculus
Assefa, N.G.; Niiranen, L.; Johnson, K.A.; Leiros, H.K.; Smalas, A.O.; Willassen, N.P.; Moe, E.
Structural and biophysical analysis of interactions between cod and human uracil-DNA N-glycosylase (UNG) and UNG inhibitor (Ugi)
Acta Crystallogr. Sect. D
70
2093-2100
2014
Homo sapiens (P13051), Homo sapiens, Gadus morhua (Q9I983), Gadus morhua
Schonhoft, J.D.; Kosowicz, J.G.; Stivers, J.T.
DNA translocation by human uracil DNA glycosylase: role of DNA phosphate charge
Biochemistry
52
2526-2535
2013
Homo sapiens
Tao, J.; Song, P.; Sato, Y.; Nishizawa, S.; Teramae, N.; Tong, A.; Xiang, Y.
A label-free and sensitive fluorescent method for the detection of uracil-DNA glycosylase activity
Chem. Commun. (Camb. )
51
929-932
2015
Homo sapiens
Assefa, N.; Niiranen, L.; Willassen, N.; Smals, A.; Moe, E.
Thermal unfolding studies of cold adapted uracil-DNA N-glycosylase (UNG) from Atlantic cod (Gadus morhua). A comparative study with human UNG
Comp. Biochem. Physiol. B
161
60-68
2012
Gadus morhua, Homo sapiens (P13051), Homo sapiens
Hegre, S.A.; Saetrom, P.; Aas, P.A.; Pettersen, H.S.; Otterlei, M.; Krokan, H.E.
Multiple microRNAs may regulate the DNA repair enzyme uracil-DNA glycosylase
DNA Repair
12
80-86
2013
Homo sapiens
Franco, D.; Sgrignani, J.; Bussi, G.; Magistrato, A.
Structural role of uracil DNA glycosylase for the recognition of uracil in DNA duplexes. Clues from atomistic simulations
J. Chem. Inf. Model.
53
1371-1387
2013
Homo sapiens (P13051)
Kitamura, K.; Wang, Z.; Chowdhury, S.; Simadu, M.; Koura, M.; Muramatsu, M.
Uracil DNA glycosylase counteracts APOBEC3G-induced hypermutation of hepatitis B viral genomes: excision repair of covalently closed circular DNA
PLoS Pathog.
9
e1003361
2013
Homo sapiens
Weil, A.F.; Ghosh, D.; Zhou, Y.; Seiple, L.; McMahon, M.A.; Spivak, A.M.; Siliciano, R.F.; Stivers, J.T.
Uracil DNA glycosylase initiates degradation of HIV-1 cDNA containing misincorporated dUTP and prevents viral integration
Proc. Natl. Acad. Sci. USA
110
E448-E457
2013
Homo sapiens
Wu, Y.; Wang, L.; Zhu, J.; Jiang, W.
A DNA machine-based fluorescence amplification strategy for sensitive detection of uracil-DNA glycosylase activity
Biosens. Bioelectron.
68
654-659
2015
Homo sapiens
Ahn, J.K.; Lee, C.Y.; Park, K.S.; Park, H.G.
Abasic site-assisted inhibition of nicking endonuclease activity for the sensitive determination of uracil DNA glycosylase
Biotechnol. J.
13
e1700603
2018
Homo sapiens
Assefa, N. G.; Niiranen, L.; Willassen, N. P.; Smalas, A.; Moe, E.
Thermal unfolding studies of cold adapted uracil-DNA N-glycosylase (UNG) from Atlantic cod (Gadus morhua). A comparative study with human UNG
Comp. Biochem. Physiol. B
161
60-68
2012
Gadus morhua, Homo sapiens (P13051), Homo sapiens
Esadze, A.; Rodriguez, G.; Weiser, B.P.; Cole, P.A.; Stivers, J.T.
Measurement of nanoscale DNA translocation by uracil DNA glycosylase in human cells
Nucleic Acids Res.
45
12413-12424
2017
Homo sapiens
Sarno, A.; Lundbaek, M.; Liabakk, N.B.; Aas, P.A.; Mjelle, R.; Hagen, L.; Sousa, M.M.L.; Krokan, H.E.; Kavli, B.
Uracil-DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil
Nucleic Acids Res.
47
4569-4585
2019
Mus musculus, Homo sapiens (P13051), Homo sapiens
Herate, C.; Vigne, C.; Guenzel, C.A.; Lambele, M.; Rouyez, M.C.; Benichou, S.
Uracil DNA glycosylase interacts with the p32 subunit of the replication protein A complex to modulate HIV-1 reverse transcription for optimal virus dissemination
Retrovirology
13
26
2016
Homo sapiens
Ren, R.; Shi, K.; Yang, J.; Yuan, R.; Xiang, Y.
DNA three way junction-mediated recycling amplification for sensitive electrochemical monitoring of uracil-DNA glycosylase activity and inhibition
Sens. Actuators B Chem.
258
783-788
2018
Homo sapiens
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