Information on EC 2.7.12.1 - dual-specificity kinase

Word Map on EC 2.7.12.1
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

EC NUMBER
COMMENTARY hide
2.7.12.1
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RECOMMENDED NAME
GeneOntology No.
dual-specificity kinase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + a protein = ADP + a phosphoprotein
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating)
This family of enzymes can phosphorylate both Ser/Thr and Tyr residues.
CAS REGISTRY NUMBER
COMMENTARY hide
134549-83-0
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
several strains
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain CDC1551 and H37Rv
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Manually annotated by BRENDA team
strain CDC1551 and H37Rv
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain PCC 7120
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain ATCC 27405
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Thermospora curvatum
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
malfunction
metabolism
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the SARK-mediated pathway may be a widespread mechanism in regulating leaf senescence
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
ATP + adaptor protein SH2 domain-containing leukocyte protein
ADP + phospho-[adaptor protein SH2 domain-containing leukocyte protein]
show the reaction diagram
ATP + amphiphysin I
ADP + phosphorylated amphiphysin I
show the reaction diagram
-
-
-
-
?
ATP + annexin 1
ADP + phospho-annexin 1
show the reaction diagram
ATP + annexin 2
ADP + phospho-annexin 2
show the reaction diagram
ATP + annexin 4
ADP + phospho-annexin 4
show the reaction diagram
ATP + biotin-Ttds-TPGSRSRTPSLPT
ADP + phosphorylated biotin-Ttds-TPGSRSRTPSLPT
show the reaction diagram
ATP + biotin-Ttds-VGLLKLASPELER
ADP + phosphorylated biotin-Ttds-VGLLKLASPELER
show the reaction diagram
ATP + casein
ADP + phosphorylated casein
show the reaction diagram
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-
-
-
?
ATP + caspase-9
ADP + phosphorylated caspase-9
show the reaction diagram
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-
-
-
?
ATP + CREB
ADP + phosphorylated CREB
show the reaction diagram
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-
-
-
?
ATP + cyclin L2
ADP + phosphorylated cyclin L2
show the reaction diagram
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-
-
-
?
ATP + dynamin 1
ADP + phosphorylated dynamin 1
show the reaction diagram
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-
-
-
?
ATP + dynamin I
ADP + phosphorylated dynamin I
show the reaction diagram
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-
-
-
?
ATP + eIF2Bepsilon
ADP + phosphorylated eIF2Bepsilon
show the reaction diagram
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-
-
-
?
ATP + extracellular MAP kinase kinase
ADP + phospho-[MAP kinase kinase]
show the reaction diagram
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-
-
-
?
ATP + extracellular signal-regulated kinase
ADP + phospho-[extracellular signal-regulated kinase]
show the reaction diagram
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-
-
-
?
ATP + Gli1 protein
ADP + phosphorylated Gli1 protein
show the reaction diagram
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-
-
-
?
ATP + glycogen synthase
ADP + phosphorylated glycogen synthase
show the reaction diagram
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-
-
-
?
ATP + histone
ADP + phosphorylated histone
show the reaction diagram
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recombinant glutathione S-transferase-Dyrk/fusion protein catalyzes histone phosphorylation on tyrosine and Ser/Thr residues
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?
ATP + histone H1
ADP + phosphorylated histone H1
show the reaction diagram
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?
ATP + immunglobulin-alpha
ADP + phospho-[immunglobulin-alpha]
show the reaction diagram
ATP + insulin receptor kinase substrate 1
ADP + phosphorylated insulin receptor kinase substrate 1
show the reaction diagram
ATP + microtubule associated protein 1B
ADP + phosphorylated microtubule associated protein 1B
show the reaction diagram
-
DYRK1A phosphorylates the S1392 site on microtubule associated protein 1B
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?
ATP + myelin basic protein
ADP + phospho-[myelin basic protein]
show the reaction diagram
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the substrate is phosphorylated on Ser, Thr, and Tyr residues by PrkG
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-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
show the reaction diagram
ATP + neurodegeneration-related septin 4
ADP + phosphorylated neurodegeneration-related septin 4
show the reaction diagram
-
SEPT4, also known as Pnutl2/CDCrel-2
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?
ATP + NFAT
ADP + phosphorylated NFAT
show the reaction diagram
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-
-
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?
ATP + Notch protein
ADP + phosphorylated Notch protein
show the reaction diagram
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-
-
-
?
ATP + p27
ADP + phospho-p27
show the reaction diagram
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p27 phosphorylation at Ser10 and Thr198
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?
ATP + peptide DYRKtide
ADP + phosphorylated peptide DYRKtide
show the reaction diagram
ATP + poly-(Tyr-Glu)
ADP + phospho-poly-(Tyr-Glu)
show the reaction diagram
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tyrosine kinase substrate
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?
ATP + Pop2p
ADP + phosphorylated Pop2p
show the reaction diagram
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-
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?
ATP + PRAS40
ADP + phospho-PRAS40
show the reaction diagram
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phosphorylation at Thr246
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?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
ATP + protein tyrosine
ADP + protein tyrosine phosphate
show the reaction diagram
autophosphorylated on Ser and Thr residues
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?
ATP + pyruvate kinase
ADP + phospho-[pyruvate kinase]
show the reaction diagram
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phosphorylated by PrkD on Ser and Thr residues
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?
ATP + RNA binding family protein
ADP + phospho-RNA binding family protein
show the reaction diagram
ATP + RRARKLTATPTPLGG
ADP + phosphorylated RRARKLTATPTPLGG
show the reaction diagram
ATP + RRRFRPASPLRGPPK
ADP + RRRFRPApSPLRGPPK
show the reaction diagram
ATP + S6K1
ADP + phospho-S6K1
show the reaction diagram
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phosphorylation at Thr389
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?
ATP + Ser/Arg-rich splicing factors
ADP + phosphorylated Ser/Arg-rich splicing factor
show the reaction diagram
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?
ATP + serine/arginine-rich protein 55
ADP + phospho-serine/arginine-rich protein 55
show the reaction diagram
ATP + SF3B1 protein-L-Thr434
ADP + [SF3B1 protein]-L-Thr434 phosphate
show the reaction diagram
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?
ATP + splicing factor 2
ADP + phosphorylated splicing factor 2
show the reaction diagram
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?
ATP + splicing factor 3
ADP + phosphorylated splicing factor 3
show the reaction diagram
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?
ATP + splicing factor 3B1
ADP + phosphorylated splicing factor 3B1
show the reaction diagram
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splicing factor 3B1 is poshorylated at Thr434
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?
ATP + SR protein
ADP + ?
show the reaction diagram
ATP + SR protein
ADP + hyperphosphorylated SR protein
show the reaction diagram
i.e. serine-rich and arginine-rich proteins
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?
ATP + STAT3
ADP + phosphorylated STAT3
show the reaction diagram
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?
ATP + synaptojanin I
ADP + phosphorylated synaptojanin I
show the reaction diagram
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?
ATP + tau protein-L-Thr434
ADP + [tau protein]-L-Thr434 phosphate
show the reaction diagram
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?
ATP + transcription factor FKHR
ADP + phosphorylated transcription factor FKHR
show the reaction diagram
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?
ATP + VSNGSPSLER
ADP + VSNGpSPSLER
show the reaction diagram
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a p27-derived peptide, residues 6-15
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?
biliverdin + ?
bilirubin + ?
show the reaction diagram
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?
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
ATP + adaptor protein SH2 domain-containing leukocyte protein
ADP + phospho-[adaptor protein SH2 domain-containing leukocyte protein]
show the reaction diagram
P43405
phosphorylation of SLP-65 on several tyrosines
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?
ATP + amphiphysin I
ADP + phosphorylated amphiphysin I
show the reaction diagram
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?
ATP + annexin 1
ADP + phospho-annexin 1
show the reaction diagram
ATP + annexin 2
ADP + phospho-annexin 2
show the reaction diagram
ATP + annexin 4
ADP + phospho-annexin 4
show the reaction diagram
ATP + caspase-9
ADP + phosphorylated caspase-9
show the reaction diagram
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?
ATP + CREB
ADP + phosphorylated CREB
show the reaction diagram
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?
ATP + cyclin L2
ADP + phosphorylated cyclin L2
show the reaction diagram
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?
ATP + dynamin 1
ADP + phosphorylated dynamin 1
show the reaction diagram
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?
ATP + dynamin I
ADP + phosphorylated dynamin I
show the reaction diagram
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-
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?
ATP + eIF2Bepsilon
ADP + phosphorylated eIF2Bepsilon
show the reaction diagram
-
-
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?
ATP + extracellular MAP kinase kinase
ADP + phospho-[MAP kinase kinase]
show the reaction diagram
-
-
-
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?
ATP + extracellular signal-regulated kinase
ADP + phospho-[extracellular signal-regulated kinase]
show the reaction diagram
-
-
-
-
?
ATP + Gli1 protein
ADP + phosphorylated Gli1 protein
show the reaction diagram
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?
ATP + glycogen synthase
ADP + phosphorylated glycogen synthase
show the reaction diagram
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-
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?
ATP + immunglobulin-alpha
ADP + phospho-[immunglobulin-alpha]
show the reaction diagram
P43405
the inhibitory residue of Ig-alpha S197 is phosphorylated in activated B cells by Syk
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?
ATP + insulin receptor kinase substrate 1
ADP + phosphorylated insulin receptor kinase substrate 1
show the reaction diagram
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phosphorylation at serine residues, overview, the enzyme is involved in the insulin signaling pathway
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?
ATP + microtubule associated protein 1B
ADP + phosphorylated microtubule associated protein 1B
show the reaction diagram
-
DYRK1A phosphorylates the S1392 site on microtubule associated protein 1B
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?
ATP + neurodegeneration-related septin 4
ADP + phosphorylated neurodegeneration-related septin 4
show the reaction diagram
-
SEPT4, also known as Pnutl2/CDCrel-2
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?
ATP + NFAT
ADP + phosphorylated NFAT
show the reaction diagram
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-
-
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?
ATP + Notch protein
ADP + phosphorylated Notch protein
show the reaction diagram
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?
ATP + p27
ADP + phospho-p27
show the reaction diagram
-
p27 phosphorylation at Ser10 and Thr198
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?
ATP + PRAS40
ADP + phospho-PRAS40
show the reaction diagram
-
phosphorylation at Thr246
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?
ATP + RNA binding family protein
ADP + phospho-RNA binding family protein
show the reaction diagram
ATP + S6K1
ADP + phospho-S6K1
show the reaction diagram
-
phosphorylation at Thr389
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?
ATP + serine/arginine-rich protein 55
ADP + phospho-serine/arginine-rich protein 55
show the reaction diagram
-
i.e. splicing factor SRp55, DYRK1a mainly phosphorylates the proline-rich domain of SRp55
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?
ATP + SF3B1 protein-L-Thr434
ADP + [SF3B1 protein]-L-Thr434 phosphate
show the reaction diagram
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?
ATP + splicing factor 2
ADP + phosphorylated splicing factor 2
show the reaction diagram
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?
ATP + splicing factor 3
ADP + phosphorylated splicing factor 3
show the reaction diagram
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?
ATP + splicing factor 3B1
ADP + phosphorylated splicing factor 3B1
show the reaction diagram
-
splicing factor 3B1 is poshorylated at Thr434
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?
ATP + SR protein
ADP + ?
show the reaction diagram
ATP + STAT3
ADP + phosphorylated STAT3
show the reaction diagram
-
-
-
-
?
ATP + synaptojanin I
ADP + phosphorylated synaptojanin I
show the reaction diagram
-
-
-
-
?
ATP + tau protein-L-Thr434
ADP + [tau protein]-L-Thr434 phosphate
show the reaction diagram
-
-
-
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?
ATP + transcription factor FKHR
ADP + phosphorylated transcription factor FKHR
show the reaction diagram
-
-
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?
biliverdin + ?
bilirubin + ?
show the reaction diagram
-
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?
additional information
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(1Z)-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2(3H)-ylidene)propan-2-one
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(4Z)-1-(3,4-dichlorophenyl)-4-(4-hydroxy-3-methoxybenzylidene)pyrazolidine-3,5-dione
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82.6% inhibition at 0.01 mM
(4Z)-1-(3,4-dichlorophenyl)-4-(4-hydroxy-3-nitrobenzylidene)pyrazolidine-3,5-dione
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76% inhibition at 0.01 mM
(4Z)-1-(3,4-dichlorophenyl)-4-(4-hydroxybenzylidene)pyrazolidine-3,5-dione
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73% inhibition at 0.01 mM
(4Z)-1-(4-fluorophenyl)-4-(4-hydroxy-3-methoxybenzylidene)pyrazolidine-3,5-dione
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44% inhibition at 0.01 mM
(4Z)-4-(4-hydroxy-3-methoxybenzylidene)-1-(4-methoxyphenyl)pyrazolidine-3,5-dione
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55% inhibition at 0.01 mM
(5-[4-[ethyl(thiophen-2-ylmethyl)amino]quinazolin-6-yl]furan-2-yl)methanol
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(5-{4-[(5-methylfuran-2-yl)amino]quinazolin-6-yl}furan-2-yl)methanol
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(5-{4-[methyl(3-methylthiophen-2-yl)amino]quinazolin-6-yl}furan-2-yl)methanol
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(5Z)-2-(2,6-dichloroanilino)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazol-4-one
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i.e. GSK-626616, the DYRK kinase inhibitor GSK-626616 affects, among others, the phosphorylation of mRNA-associated proteins and proteins downstream of mTORC1 signaling
2-(1,3-benzodioxol-5-yl)-N-(3,4-dichlorobenzyl)pyrimidin-4-amine
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;
2-(1,3-benzodioxol-5-yl)-N-(4-chlorobenzyl)pyrimidin-4-amine
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;
2-(1,3-benzodioxol-5-yl)-N-(pyridin-3-ylmethyl)pyrimidin-4-amine
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;
2-(1H-indazol-5-yl)-N-(pyridin-3-ylmethyl)pyrimidin-4-amine
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;
2-(1H-indazol-6-yl)-N-(pyridin-3-ylmethyl)pyrimidin-4-amine
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;
2-methyl-5-[(4-methylphenyl)amino]benzothiazole-4,7-dione
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i.e. CDK4 inhibitor III
3-(N-benzyl-N-isopropyl)amino-1-(naphthalen-2-yl)propan-1-one hydrochloride
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i.e. Jak3 inhibitor IV
3-[4-(2-phenylethyl)quinazolin-6-yl]benzonitrile
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3-[4-[2-(4-methoxyphenyl)ethyl]quinazolin-6-yl]benzonitrile
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3-[4-[2-(4-methylphenyl)ethyl]quinazolin-6-yl]benzonitrile
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4-(1,3-benzodioxol-5-yl)-N-(3,4-dibromobenzyl)pyrimidin-2-amine
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;
4-(1,3-benzodioxol-5-yl)-N-(3,4-dichlorobenzyl)pyrimidin-2-amine
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;
4-(1,3-benzodioxol-5-yl)-N-(3,5-dibromobenzyl)pyrimidin-2-amine
-
;
4-(1,3-benzodioxol-5-yl)-N-(3,5-dichlorobenzyl)pyrimidin-2-amine
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;
4-(1,3-benzodioxol-5-yl)-N-(4-chlorobenzyl)pyrimidin-2-amine
-
;
4-(1,3-benzodioxol-5-yl)-N-(4-chlorophenyl)pyrimidin-2-amine
-
;
4-(1,3-benzodioxol-5-yl)-N-(pyridin-3-ylmethyl)pyrimidin-2-amine
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;
4-(1,3-benzodioxol-5-yl)-N-[2-bromo-4-(trifluoromethyl)phenyl]pyrimidin-2-amine
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;
4-(1,3-benzodioxol-5-yl)-N-[4-(trifluoromethyl)phenyl]pyrimidin-2-amine
-
;
4-(1H-indazol-5-yl)-N-(pyridin-3-ylmethyl)pyrimidin-2-amine
-
;
4-(1H-indazol-6-yl)-N-(pyridin-3-ylmethyl)pyrimidin-2-amine
-
;
4-(2-phenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione
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i.e. Wee1/Chk1 inhibitor
4-(6-cyclohexylmethoxy-9H-purin-2-ylamino)-N,N-diethylbenzamide
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i.e. CDK2 inhibitor IV
4-[(4Z)-4-(4-hydroxy-3-methoxybenzylidene)-3,5-dioxopyrazolidin-1-yl]benzonitrile
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78% inhibition at 0.01 mM
5-chloro-3-(3,5-dichloro-4-hydroxybenzylidene)-1,3-dihydro-indol-2-one
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i.e. HMS3229I17, a CDK2 inhibitor IV
5-[4-(thiophen-2-ylamino)quinazolin-6-yl]furan-2-carboxylic acid
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-
5-{4-[(5-methylfuran-2-yl)amino]quinazolin-6-yl}furan-2-carboxylic acid
-
-
6-(1,3-benzodioxol-5-yl)-N-(1,3-thiazol-2-yl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-(1,3-thiazol-2-ylmethyl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-(1H-imidazol-2-yl)-N-methylquinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-(1H-imidazol-2-yl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-(1H-imidazol-2-ylmethyl)-N-methylquinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-(1H-imidazol-2-ylmethyl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-(1H-imidazol-4-ylmethyl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-(2,2-dimethylpropyl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-(2-methyl-1,3-thiazol-4-yl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-(2-methylfuran-3-yl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-(3,4-dichlorobenzyl)pyrimidin-4-amine
-
;
6-(1,3-benzodioxol-5-yl)-N-(3,5-dichlorobenzyl)pyrimidin-4-amine
-
;
6-(1,3-benzodioxol-5-yl)-N-(3,5-dichlorobenzyl)quinazolin-4-amine
-
;
6-(1,3-benzodioxol-5-yl)-N-(3-methylthiophen-2-yl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-(4-chlorobenzyl)pyrimidin-4-amine
-
;
6-(1,3-benzodioxol-5-yl)-N-(4-methoxybenzyl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-(5-methylfuran-2-yl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-(5-methylthiophen-2-yl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-(cyclopentylmethyl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-(furan-2-yl)-N-methylquinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-(furan-2-yl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-(furan-2-ylmethyl)-N-methylquinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-(furan-2-ylmethyl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-(furan-3-yl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-(furan-3-ylmethyl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-(pyridin-3-ylmethyl)pyrimidin-4-amine
-
;
6-(1,3-benzodioxol-5-yl)-N-(tetrahydro-2H-pyran-2-ylmethyl)quinazolin-4-amine
-
-
-
6-(1,3-benzodioxol-5-yl)-N-(tetrahydro-2H-pyran-3-yl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-(tetrahydrofuran-2-yl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-(tetrahydrofuran-2-ylmethyl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-(tetrahydrofuran-3-yl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-(tetrahydrofuran-3-ylmethyl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-(thiophen-2-yl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-(thiophen-2-ylmethyl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-benzylquinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-cyclopentylquinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-ethyl-N-(thiophen-2-yl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-ethyl-N-(thiophen-2-ylmethyl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-methyl-N-(1,3-thiazol-2-yl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-methyl-N-(1,3-thiazol-2-ylmethyl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-methyl-N-(2-methyl-1,3-thiazol-4-yl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-methyl-N-(3-methylthiophen-2-yl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-methyl-N-(4-methyl-1,3-thiazol-2-yl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-methyl-N-(5-methyl-1,3,4-oxadiazol-2-yl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-methyl-N-(thiophen-2-yl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-methyl-N-(thiophen-2-ylmethyl)quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-methyl-N-[(3-methylthiophen-2-yl)methyl]quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-methyl-N-[(4-methyl-1,3-thiazol-2-yl)methyl]quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-methyl-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-[(2-methylfuran-3-yl)methyl]quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-[(3-methylthiophen-2-yl)methyl]quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-[(4-methyl-1,3-thiazol-2-yl)methyl]quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-[(5-methylfuran-2-yl)methyl]quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-[(5-methylthiophen-2-yl)methyl]quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-[2-(1H-imidazol-4-yl)ethyl]quinazolin-4-amine
-
-
6-(1,3-benzodioxol-5-yl)-N-[2-(furan-2-yl)ethyl]quinazolin-4-amine
-
-
6-(1-methyl-1H-indazol-6-yl)-N-(thiophen-2-yl)quinazolin-4-amine
-
-
6-(1-methyl-1H-indol-5-yl)-N-(thiophen-2-yl)quinazolin-4-amine
-
-
6-(1-methyl-1H-indol-5-yl)-N-(thiophen-2-ylmethyl)quinazolin-4-amine
-
-
6-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-(thiophen-2-ylmethyl)quinazolin-4-amine
-
-
6-(2-chlorophenyl)-N-(thiophen-2-yl)quinazolin-4-amine
-
-
6-(2-chlorophenyl)-N-(thiophen-2-ylmethyl)quinazolin-4-amine
-
-
6-(2-methylfuran-3-yl)-N-(5-methylfuran-2-yl)quinazolin-4-amine
-
-
6-(2-methylfuran-3-yl)-N-[(5-methylfuran-2-yl)methyl]quinazolin-4-amine
-
-
6-(3,4-dimethoxyphenyl)-N-(thiophen-2-yl)quinazolin-4-amine
-
-
6-(3-chlorophenyl)-N-(thiophen-2-yl)quinazolin-4-amine
-
-
6-(3-methoxyphenyl)-N-(4-methylbenzyl)quinazolin-4-amine
-
-
6-(3-methoxyphenyl)-N-(thiophen-2-yl)quinazolin-4-amine
-
-
6-(3-methoxyphenyl)-N-(thiophen-2-ylmethyl)quinazolin-4-amine
-
-
6-(3-methoxyphenyl)quinazoline
-
-
6-(3-methylphenyl)-N-(thiophen-2-yl)quinazolin-4-amine
-
-
6-(4-fluoro-1,3-benzodioxol-5-yl)-N-(thiophen-2-yl)quinazolin-4-amine
-
-
6-(4-fluoro-1,3-benzodioxol-5-yl)-N-(thiophen-2-ylmethyl)quinazolin-4-amine
-
-
6-(4-methoxyphenyl)-N-(thiophen-2-yl)quinazolin-4-amine
-
-
6-(4-methoxyphenyl)-N-(thiophen-2-ylmethyl)quinazolin-4-amine
-
-
6-(furan-2-yl)-N-(thiophen-2-yl)quinazolin-4-amine
-
-
6-(furan-2-yl)-N-(thiophen-2-ylmethyl)quinazolin-4-amine
-
-
6-(furan-3-yl)-N-(2-methyl-1,3-thiazol-4-yl)quinazolin-4-amine
-
-
6-(furan-3-yl)-N-(thiophen-2-yl)quinazolin-4-amine
-
-
6-(furan-3-yl)-N-(thiophen-2-ylmethyl)quinazolin-4-amine
-
-
6-(furan-3-yl)-N-methyl-N-(3-methylthiophen-2-yl)quinazolin-4-amine
-
-
6-(furan-3-yl)-N-methyl-N-[(3-methylthiophen-2-yl)methyl]quinazolin-4-amine
-
-
6-(furan-3-yl)-N-[(2-methyl-1,3-thiazol-4-yl)methyl]quinazolin-4-amine
-
-
6-(pyridin-3-yl)-N-(thiophen-2-yl)quinazolin-4-amine
-
-
7-(1,3-benzodioxol-5-yl)-N-(thiophen-2-yl)quinazolin-4-amine
-
-
7-methoxy-1-methyl-9H-pyrido[3,4-b]indole
-
i.e. harmine
DMSO
-
-
ethyl 5-(4-[[(2-methyl-1,3-thiazol-4-yl)methyl]amino]quinazolin-6-yl)furan-2-carboxylate
-
-
ethyl 5-(4-[[(3-methylthiophen-2-yl)methyl]amino]quinazolin-6-yl)furan-2-carboxylate
-
-
ethyl 5-(4-[[(5-methylfuran-2-yl)methyl]amino]quinazolin-6-yl)furan-2-carboxylate
-
-
ethyl 5-(4-[[2-(1H-imidazol-4-yl)ethyl]amino]quinazolin-6-yl)furan-2-carboxylate
-
-
ethyl 5-[4-(1H-imidazol-2-ylamino)quinazolin-6-yl]furan-2-carboxylate
-
-
ethyl 5-[4-(thiophen-2-ylamino)quinazolin-6-yl]furan-2-carboxylate
-
-
ethyl 5-[4-[(1H-imidazol-2-ylmethyl)amino]quinazolin-6-yl]furan-2-carboxylate
-
-
ethyl 5-[4-[ethyl(thiophen-2-ylmethyl)amino]quinazolin-6-yl]furan-2-carboxylate
-
-
ethyl 5-{4-[(1H-imidazol-4-ylmethyl)amino]quinazolin-6-yl}furan-2-carboxylate
-
-
ethyl 5-{4-[(2-methyl-1,3-thiazol-4-yl)amino]quinazolin-6-yl}furan-2-carboxylate
-
-
ethyl 5-{4-[(5-methylfuran-2-yl)amino]quinazolin-6-yl}furan-2-carboxylate
-
-
ethyl 5-{4-[methyl(3-methylthiophen-2-yl)amino]quinazolin-6-yl}furan-2-carboxylate
-
-
genistein
harmine
HCD160
-
82.6% inhibition at 0.01 mM
leucettamine
-
marine alkaloid, strong inhibitor
-
leucettine L-41
-
-
-
midostaurin
-
i.e. PKC412, a derivative of the broad-spectrum kinase inhibitor staurosporine, an alkaloid isolated from Streptomyces staurosoreus; i.e. PKC412, a derivative of the broad-spectrum kinase inhibitor staurosporine, an alkaloid isolated from Streptomyces staurosoreus. Enzyme binding structure analysis, overview
ML315
-
;
-
N,4-bis(1,3-benzodioxol-5-yl)pyrimidin-2-amine
-
;
N-(2,2-dimethylpropyl)-6-[5-[(ethylamino)methyl]furan-2-yl]quinazolin-4-amine
-
-
N-(3,4-dichlorobenzyl)-2-(1H-indazol-5-yl)pyrimidin-4-amine
-
;
N-(3,4-dichlorobenzyl)-4-(1H-indazol-5-yl)pyrimidin-2-amine
-
;
N-(3,4-dichlorobenzyl)-4-(1H-indazol-6-yl)pyrimidin-2-amine
-
;
N-(3,4-dichlorobenzyl)-4-(2,3-dihydro-1,4-benzodioxin-6-yl)pyrimidin-2-amine
-
;
N-(3,4-dichlorobenzyl)-4-(3,4-dimethoxyphenyl)pyrimidin-2-amine
-
-
N-(3,4-dichlorobenzyl)-4-(3-methoxyphenyl)pyrimidin-2-amine
-
;
N-(3,4-dichlorobenzyl)-4-(4-methoxyphenyl)pyrimidin-2-amine
-
;
N-(3,4-dichlorobenzyl)-6-(pyridin-3-yl)quinazolin-4-amine
-
-
N-(4-chlorobenzyl)-4-(3-methoxyphenyl)pyrimidin-2-amine
-
;
N-(4-chlorobenzyl)-4-(4-methoxyphenyl)pyrimidin-2-amine
-
;
N-(4-chlorobenzyl)-6-(3-methoxyphenyl)quinazolin-4-amine
-
-
N-(4-chlorobenzyl)-6-(pyridin-3-yl)quinazolin-4-amine
-
-
N-(4-methoxybenzyl)-6-(3-methoxyphenyl)quinazolin-4-amine
-
-
N-(4-methoxybenzyl)-6-(pyridin-3-yl)quinazolin-4-amine
-
-
N-(thiophen-2-yl)-6-(3,4,5-trimethoxyphenyl)quinazolin-4-amine
-
-
N-tert-butyl-6-{5-[(ethylamino)methyl]furan-2-yl}quinazolin-4-amine
-
-
N6-Dimethylaminopurine
-
unspecific inhibitor of protein kinases
RAD-001
-
a rapamycin derivative
-
roscovitine
-
63% inhibition at 0.01 mM
sorbitol
-
-
staurosporine
TG003
-
;
-
tyrphostin
-
competitive versus ATP, mixed inhibition versus histone H1
Zn2+
-
inhibits the autophosphoylation, which cannot be reversed by Mn2+ addition
[5-(4-[methyl[(3-methylthiophen-2-yl)methyl]amino]quinazolin-6-yl)furan-2-yl]methanol
-
-
{5-[4-(thiophen-2-ylamino)quinazolin-6-yl]furan-2-yl}methanol
-
-
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
abscisic acid
induces the expression of isozymes DPK1-DPK3 in seedlings; induces the expression of isozymes DPK1-DPK3 in seedlings; induces the expression of isozymes DPK1-DPK3 in seedlings
H2O2
-
the kinase activity of biliverdin reductase is stimulated by generators of free radicals such as H2O2
Sodium arsenite
-
the kinase activity of biliverdin reductase is stimulated by generators of free radicals such as sodium arsenite
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.019 - 0.1185
ATP
0.006 - 0.012
histone H1
-
additional information
additional information
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.26 - 14.5
ATP
3.09 - 18.4
histone H1
-
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000017 - 0.000426
genistein
0.0000254 - 0.0000284
midostaurin
0.000056 - 0.000694
staurosporine
0.000014 - 0.000202
tyrphostin
additional information
additional information
-
inhibition kinetics of tyrosine kinase inhibitors, recombinant His-tagged wild-type and mutant enzymes
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0025
(4Z)-1-(3,4-dichlorophenyl)-4-(4-hydroxy-3-methoxybenzylidene)pyrazolidine-3,5-dione
Homo sapiens
-
for autophosphorylation
0.0006
(4Z)-1-(3,4-dichlorophenyl)-4-(4-hydroxy-3-nitrobenzylidene)pyrazolidine-3,5-dione
Homo sapiens
-
for autophosphorylation
0.0025
(4Z)-1-(3,4-dichlorophenyl)-4-(4-hydroxybenzylidene)pyrazolidine-3,5-dione
Homo sapiens
-
for autophosphorylation
0.0025
(4Z)-1-(4-fluorophenyl)-4-(4-hydroxy-3-methoxybenzylidene)pyrazolidine-3,5-dione
Homo sapiens
-
for autophosphorylation
0.0012
(4Z)-4-(4-hydroxy-3-methoxybenzylidene)-1-(4-methoxyphenyl)pyrazolidine-3,5-dione
Homo sapiens
-
for autophosphorylation
3.454 - 10
2-(1,3-benzodioxol-5-yl)-N-(3,4-dichlorobenzyl)pyrimidin-4-amine
4.579 - 8.862
2-(1,3-benzodioxol-5-yl)-N-(4-chlorobenzyl)pyrimidin-4-amine
10
2-(1,3-benzodioxol-5-yl)-N-(pyridin-3-ylmethyl)pyrimidin-4-amine
Homo sapiens
-
above, pH and temperature not specified in the publication; above, pH and temperature not specified in the publication
0.179 - 0.349
2-(1H-indazol-5-yl)-N-(pyridin-3-ylmethyl)pyrimidin-4-amine
0.829 - 1.434
2-(1H-indazol-6-yl)-N-(pyridin-3-ylmethyl)pyrimidin-4-amine
0.0164
3-[4-[2-(4-methoxyphenyl)ethyl]quinazolin-6-yl]benzonitrile
Homo sapiens
-
pH and temperature not specified in the publication
0.0412
3-[4-[2-(4-methylphenyl)ethyl]quinazolin-6-yl]benzonitrile
Homo sapiens
-
pH and temperature not specified in the publication
0.018 - 0.112
4-(1,3-benzodioxol-5-yl)-N-(3,4-dibromobenzyl)pyrimidin-2-amine
0.014 - 0.038
4-(1,3-benzodioxol-5-yl)-N-(3,4-dichlorobenzyl)pyrimidin-2-amine
0.009 - 0.018
4-(1,3-benzodioxol-5-yl)-N-(3,5-dibromobenzyl)pyrimidin-2-amine
0.004 - 0.007
4-(1,3-benzodioxol-5-yl)-N-(3,5-dichlorobenzyl)pyrimidin-2-amine
0.273 - 0.884
4-(1,3-benzodioxol-5-yl)-N-(4-chlorophenyl)pyrimidin-2-amine
0.012 - 0.016
4-(1,3-benzodioxol-5-yl)-N-(pyridin-3-ylmethyl)pyrimidin-2-amine
0.107 - 0.137
4-(1,3-benzodioxol-5-yl)-N-[2-bromo-4-(trifluoromethyl)phenyl]pyrimidin-2-amine
0.01 - 0.018
4-(1,3-benzodioxol-5-yl)-N-[4-(trifluoromethyl)phenyl]pyrimidin-2-amine
0.061 - 0.093
4-(1H-indazol-5-yl)-N-(pyridin-3-ylmethyl)pyrimidin-2-amine
0.0006
4-[(4Z)-4-(4-hydroxy-3-methoxybenzylidene)-3,5-dioxopyrazolidin-1-yl]benzonitrile
Homo sapiens
-
for autophosphorylation
0.282 - 1.156
6-(1,3-benzodioxol-5-yl)-N-(3,5-dichlorobenzyl)quinazolin-4-amine
0.0463
6-(1,3-benzodioxol-5-yl)-N-(4-methoxybenzyl)quinazolin-4-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.026
6-(1,3-benzodioxol-5-yl)-N-benzylquinazolin-4-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.0654
6-(3-methoxyphenyl)-N-(4-methylbenzyl)quinazolin-4-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.026
6-(3-methoxyphenyl)quinazoline
Homo sapiens
-
pH and temperature not specified in the publication
0.000033 - 0.001
harmine
0.00004
leucettine L-41
Homo sapiens
-
pH and temperature not specified in the publication
-
0.000059 - 0.000066
midostaurin
0.025 - 0.042
N,4-bis(1,3-benzodioxol-5-yl)pyrimidin-2-amine
0.514 - 2.352
N-(3,4-dichlorobenzyl)-2-(1H-indazol-5-yl)pyrimidin-4-amine
0.0129 - 0.125
N-(3,4-dichlorobenzyl)-4-(1H-indazol-5-yl)pyrimidin-2-amine
0.0169 - 0.599
N-(3,4-dichlorobenzyl)-4-(1H-indazol-6-yl)pyrimidin-2-amine
0.013 - 0.055
N-(3,4-dichlorobenzyl)-4-(2,3-dihydro-1,4-benzodioxin-6-yl)pyrimidin-2-amine
10
N-(3,4-dichlorobenzyl)-4-(3,4-dimethoxyphenyl)pyrimidin-2-amine
Homo sapiens
-
above, pH and temperature not specified in the publication
4.654 - 10
N-(3,4-dichlorobenzyl)-4-(3-methoxyphenyl)pyrimidin-2-amine
0.203 - 0.411
N-(3,4-dichlorobenzyl)-4-(4-methoxyphenyl)pyrimidin-2-amine
0.0412
N-(3,4-dichlorobenzyl)-6-(pyridin-3-yl)quinazolin-4-amine
Homo sapiens
-
pH and temperature not specified in the publication
6.361 - 6.782
N-(4-chlorobenzyl)-4-(3-methoxyphenyl)pyrimidin-2-amine
0.558 - 0.871
N-(4-chlorobenzyl)-4-(4-methoxyphenyl)pyrimidin-2-amine
0.0207
N-(4-chlorobenzyl)-6-(3-methoxyphenyl)quinazolin-4-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.0292
N-(4-chlorobenzyl)-6-(pyridin-3-yl)quinazolin-4-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.026
N-(4-methoxybenzyl)-6-(3-methoxyphenyl)quinazolin-4-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.0328
N-(4-methoxybenzyl)-6-(pyridin-3-yl)quinazolin-4-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.000012 - 0.00013
TG003
-
additional information
additional information
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.8
-
assay at; assay at
7
-
assay at
8.4
-
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
22
-
assay at room temperature; assay at room temperature
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
transfection analysis
Manually annotated by BRENDA team
-
DYRK2 level is lower in primary or metastatic colorectal carcinoma compared to adjacent normal colon tissue or non-metastatic colorectal carcinoma, respectively. DYRK2 expression analysis of in 181 archived colorectal carcinoma samples, overview
Manually annotated by BRENDA team
-
human brain microvascular endothelial cells
Manually annotated by BRENDA team
DYRK3 expression in, ex vivo analysis of erythroid progenitor cells of DYRK3-knockout mice
Manually annotated by BRENDA team
-
DYRK3 is initially identified as an erythroid kinase (REDK), as the gene is expressed preferentially in erythroid cells
Manually annotated by BRENDA team
-
levels of TTK protein are significantly elevated in neoplastic tissues from a cohort of liver cancer patients, when compared with adjacent hepatic tissues
Manually annotated by BRENDA team
-
levels of TTK protein are significantly elevated in neoplastic tissues from a cohort of liver cancer patients, when compared with adjacent hepatic tissues
Manually annotated by BRENDA team
-
transfection analysis
Manually annotated by BRENDA team
-
strong overexpression of dual specificity kinase TTK
Manually annotated by BRENDA team
-
retinal pigmented epithelial cells
Manually annotated by BRENDA team
co-expression experiments in
Manually annotated by BRENDA team
high expression of DPK1 in immature spikes; low expression of DPK4
Manually annotated by BRENDA team
low expression of DPK2; low expression of DPK4
Manually annotated by BRENDA team
-
transfection analysis, degradation of the tumor suppressor pRb in a dose-dependent manner based on the accumulation of HPV16E7 generated by DYRK1A transfection
Manually annotated by BRENDA team
additional information