Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(5-{4-[(5-methylfuran-2-yl)amino]quinazolin-6-yl}furan-2-yl)methanol | - |
Homo sapiens | |
(5-{4-[methyl(3-methylthiophen-2-yl)amino]quinazolin-6-yl}furan-2-yl)methanol | - |
Homo sapiens | |
5-[4-(thiophen-2-ylamino)quinazolin-6-yl]furan-2-carboxylic acid | - |
Homo sapiens | |
5-{4-[(5-methylfuran-2-yl)amino]quinazolin-6-yl}furan-2-carboxylic acid | - |
Homo sapiens | |
6-(1,3-benzodioxol-5-yl)-N-(1,3-thiazol-2-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(1,3-benzodioxol-5-yl)-N-(1H-imidazol-2-yl)-N-methylquinazolin-4-amine | - |
Homo sapiens | |
6-(1,3-benzodioxol-5-yl)-N-(1H-imidazol-2-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(1,3-benzodioxol-5-yl)-N-(1H-imidazol-4-ylmethyl)quinazolin-4-amine | - |
Homo sapiens | |
6-(1,3-benzodioxol-5-yl)-N-(2,2-dimethylpropyl)quinazolin-4-amine | - |
Homo sapiens | |
6-(1,3-benzodioxol-5-yl)-N-(2-methyl-1,3-thiazol-4-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(1,3-benzodioxol-5-yl)-N-(2-methylfuran-3-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(1,3-benzodioxol-5-yl)-N-(3-methylthiophen-2-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(1,3-benzodioxol-5-yl)-N-(5-methylfuran-2-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(1,3-benzodioxol-5-yl)-N-(5-methylthiophen-2-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(1,3-benzodioxol-5-yl)-N-(furan-2-yl)-N-methylquinazolin-4-amine | - |
Homo sapiens | |
6-(1,3-benzodioxol-5-yl)-N-(furan-2-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(1,3-benzodioxol-5-yl)-N-(furan-3-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(1,3-benzodioxol-5-yl)-N-(tetrahydro-2H-pyran-3-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(1,3-benzodioxol-5-yl)-N-(tetrahydrofuran-2-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(1,3-benzodioxol-5-yl)-N-(tetrahydrofuran-3-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(1,3-benzodioxol-5-yl)-N-(thiophen-2-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(1,3-benzodioxol-5-yl)-N-cyclopentylquinazolin-4-amine | - |
Homo sapiens | |
6-(1,3-benzodioxol-5-yl)-N-ethyl-N-(thiophen-2-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(1,3-benzodioxol-5-yl)-N-methyl-N-(1,3-thiazol-2-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(1,3-benzodioxol-5-yl)-N-methyl-N-(2-methyl-1,3-thiazol-4-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(1,3-benzodioxol-5-yl)-N-methyl-N-(3-methylthiophen-2-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(1,3-benzodioxol-5-yl)-N-methyl-N-(4-methyl-1,3-thiazol-2-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(1,3-benzodioxol-5-yl)-N-methyl-N-(5-methyl-1,3,4-oxadiazol-2-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(1,3-benzodioxol-5-yl)-N-methyl-N-(thiophen-2-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(1-methyl-1H-indazol-6-yl)-N-(thiophen-2-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(1-methyl-1H-indol-5-yl)-N-(thiophen-2-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(2-chlorophenyl)-N-(thiophen-2-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(2-methylfuran-3-yl)-N-(5-methylfuran-2-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(3,4-dimethoxyphenyl)-N-(thiophen-2-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(3-chlorophenyl)-N-(thiophen-2-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(3-methoxyphenyl)-N-(thiophen-2-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(3-methylphenyl)-N-(thiophen-2-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(4-fluoro-1,3-benzodioxol-5-yl)-N-(thiophen-2-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(4-methoxyphenyl)-N-(thiophen-2-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(furan-2-yl)-N-(thiophen-2-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(furan-3-yl)-N-(2-methyl-1,3-thiazol-4-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(furan-3-yl)-N-(thiophen-2-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(furan-3-yl)-N-methyl-N-(3-methylthiophen-2-yl)quinazolin-4-amine | - |
Homo sapiens | |
6-(pyridin-3-yl)-N-(thiophen-2-yl)quinazolin-4-amine | - |
Homo sapiens | |
7-(1,3-benzodioxol-5-yl)-N-(thiophen-2-yl)quinazolin-4-amine | - |
Homo sapiens | |
ethyl 5-[4-(1H-imidazol-2-ylamino)quinazolin-6-yl]furan-2-carboxylate | - |
Homo sapiens | |
ethyl 5-[4-(thiophen-2-ylamino)quinazolin-6-yl]furan-2-carboxylate | - |
Homo sapiens | |
ethyl 5-{4-[(1H-imidazol-4-ylmethyl)amino]quinazolin-6-yl}furan-2-carboxylate | - |
Homo sapiens | |
ethyl 5-{4-[(2-methyl-1,3-thiazol-4-yl)amino]quinazolin-6-yl}furan-2-carboxylate | - |
Homo sapiens | |
ethyl 5-{4-[(5-methylfuran-2-yl)amino]quinazolin-6-yl}furan-2-carboxylate | - |
Homo sapiens | |
ethyl 5-{4-[methyl(3-methylthiophen-2-yl)amino]quinazolin-6-yl}furan-2-carboxylate | - |
Homo sapiens | |
additional information | synthesis and evaluation of a series of 6-arylquinazolin-4-amine inhibitors as enzyme inhibitors, three-dimensional quantitative structure-activity relationship (3D-QSAR) studies, binding mode from docking studies, molecular homology modeling, overview. A hydrogen bond between ligand and the counterpart Lys 188 in Dyrk1A is present in part of the crystal structures of Dyrk1A (PDB IDs 3ANQ and 3ANR). By contrast, the involvement of the residue at the same position as Leu242 in the hydrogen bond interaction is available in all identified Dyrk1A structures (PDB IDs: 3ANQ, 3ANR, 2WO6, and 2VX3) | Homo sapiens | |
N-(thiophen-2-yl)-6-(3,4,5-trimethoxyphenyl)quinazolin-4-amine | - |
Homo sapiens | |
N-tert-butyl-6-{5-[(ethylamino)methyl]furan-2-yl}quinazolin-4-amine | - |
Homo sapiens | |
{5-[4-(thiophen-2-ylamino)quinazolin-6-yl]furan-2-yl}methanol | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q13627 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
dual specificity tyrosine-phosphorylation-regulated kinase 1A Dyrk1A | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
pIC50 values of 6-arylquinazolin-4-amine inhibitors, overview | Homo sapiens | additional information |