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acyl-CoA + glycine
CoA + N-acylglycine
arachidonoyl-CoA + glycine
CoA + N-arachidonoylglycine
-
-
-
?
benzoyl-CoA + glycine
CoA + N-benzoylglycine
benzoyl-CoA + L-alanine
CoA + N-benzoyl-L-alanine
-
-
-
-
?
benzoyl-CoA + L-asparagine
CoA + N-benzoyl-L-asparagine
-
-
-
-
?
benzoyl-CoA + L-glutamic acid
CoA + N-benzoyl-L-glutamic acid
-
-
-
-
?
benzoyl-CoA + L-glutamine
CoA + N-benzoyl-L-glutamine
isovaleryl-CoA + glycine
CoA + N-isovalerylglycine
-
-
-
?
octanoyl-CoA + glycine
CoA + N-octanoylglycine
-
-
-
?
oleoyl-CoA + glycine
CoA + N-oleoyl-glycine
-
-
-
?
salicyl-CoA + glycine
CoA + salicyluric acid
-
-
-
?
stearoyl-CoA + glycine
CoA + N-stearoyl-glycine
-
-
-
?
additional information
?
-
acyl-CoA + glycine
CoA + N-acylglycine
-
-
-
?
acyl-CoA + glycine
CoA + N-acylglycine
-
-
-
?
acyl-CoA + glycine
CoA + N-acylglycine
-
-
-
-
?
acyl-CoA + glycine
CoA + N-acylglycine
-
-
-
?
acyl-CoA + glycine
CoA + N-acylglycine
-
-
-
-
?
acyl-CoA + glycine
CoA + N-acylglycine
-
the CoA derivatives of a number of aliphatic and aromatic acids, e.g. benzoyl-CoA and butyryl-CoA can act as acyl donor
-
?
acyl-CoA + glycine
CoA + N-acylglycine
-
salicyl-CoA acts as acyl donor
-
?
benzoyl-CoA + glycine
CoA + N-benzoylglycine
-
-
-
?
benzoyl-CoA + glycine
CoA + N-benzoylglycine
-
-
-
?
benzoyl-CoA + glycine
CoA + N-benzoylglycine
-
-
-
-
?
benzoyl-CoA + glycine
CoA + N-benzoylglycine
-
-
-
?
benzoyl-CoA + glycine
CoA + N-benzoylglycine
best substrates are benzoyl-CoA as an acyl donor and glycine as acyl acceptor
-
-
?
benzoyl-CoA + L-glutamine
CoA + N-benzoyl-L-glutamine
-
-
-
-
?
benzoyl-CoA + L-glutamine
CoA + N-benzoyl-L-glutamine
24% of the rate with glycine and benzoyl-CoA
-
-
?
additional information
?
-
substrates are medium- and long-chain acyl-CoAs ranging from chain-length C8:0-CoA to C18:0-CoA. Enzyme is specific for glycine as an acceptor molecule, and preferentially produces N-oleoyl glycine. No substrates: docosahexanoyl-CoA and chenodeoxycholoyl-CoA, L-alanine, l-serine
-
-
?
additional information
?
-
GLYAT exhibits mechanistic kinetic cooperativity
-
-
-
additional information
?
-
-
GLYAT exhibits mechanistic kinetic cooperativity
-
-
-
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Breast Neoplasms
Downregulation of GLYAT Facilitates Tumor Growth and Metastasis and Poor Clinical Outcomes Through the PI3K/AKT/Snail Pathway in Human Breast Cancer.
Carcinogenesis
Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
The expression and prognostic value of GLYATL1 and its potential role in hepatocellular carcinoma.
Hyperglycinemia, Nonketotic
Glycine and benzoate conjugation and glycine acyltransferase activity in the developing and adult rat: possible relationships to nonketotic hyperglycinemia.
Metabolism, Inborn Errors
Frequent sequence variants of human glycine N-acyltransferase (GLYAT) and inborn errors of metabolism.
Neoplasm Metastasis
Downregulation of GLYAT Facilitates Tumor Growth and Metastasis and Poor Clinical Outcomes Through the PI3K/AKT/Snail Pathway in Human Breast Cancer.
Neoplasms
Characterization of glycine-N-acyltransferase like 1 (GLYATL1) in prostate cancer.
Neoplasms
Downregulation of GLYAT Facilitates Tumor Growth and Metastasis and Poor Clinical Outcomes Through the PI3K/AKT/Snail Pathway in Human Breast Cancer.
Neoplasms
Glycine conjugation: importance in metabolism, the role of glycine N-acyltransferase, and factors that influence interindividual variation.
Neoplasms
Overexpression of lipid metabolism genes and PBX1 in the contralateral breasts of women with estrogen receptor-negative breast cancer.
Neoplasms
The expression and prognostic value of GLYATL1 and its potential role in hepatocellular carcinoma.
Porphyrias
The role of substrates for glycine acyltransferase, and the role of sulfanilamide and acetate in the reversal of chemically-induced porphyria in the rat.
Prostatic Neoplasms
Characterization of glycine-N-acyltransferase like 1 (GLYATL1) in prostate cancer.
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997
alanine
-
acyl donor benzoyl-CoA
0.0044
oleoyl-CoA
pH not specified in the publication, temperature not specified in the publication
0.021
benzoyl-CoA
mutant enzyme K16N, apparent value, at pH 8.0 and 37°C
0.024
benzoyl-CoA
wild type enzyme, apparent value, at pH 8.0 and 37°C
0.028
benzoyl-CoA
mutant enzyme S17T, apparent value, at pH 8.0 and 37°C
0.038
benzoyl-CoA
mutant enzyme N156S, apparent value, at pH 8.0 and 37°C
0.053
benzoyl-CoA
mutant enzyme F168L, apparent value, at pH 8.0 and 37°C
0.071
benzoyl-CoA
mutant enzyme R131H, apparent value, at pH 8.0 and 37°C
13
benzoyl-CoA
-
cosubstrate glycine
15.2
benzoyl-CoA
-
cosubstrate alanine
30.42
benzoyl-CoA
K0.5 value at 2.5 mM gylcine, pH 8.0, temperature not specified in the publication
108.3
benzoyl-CoA
K0.5 value at 5 mM gylcine, pH 8.0, temperature not specified in the publication
305
benzoyl-CoA
K0.5 value at 20 mM gylcine, pH 8.0, temperature not specified in the publication
2.189
glycine
K0.5 value at 0.02 mM benzoyl-CoA, pH 8.0, temperature not specified in the publication
2.326
glycine
K0.5 value at 0.04 mM benzoyl-CoA, pH 8.0, temperature not specified in the publication
2.956
glycine
K0.5 value at 0.08 mM benzoyl-CoA, pH 8.0, temperature not specified in the publication
6.4
glycine
-
acyl donor benzoyl-CoA
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Arg131His
polymorphism resulting in an amino acid change of Arg131His, in Japanese individuals
Q61L
the mutation has a negative effect on the enzyme activity
F168L
the mutant shows decreased activity compared to the wild type enzyme
F168L
the mutation has a negative effect on the enzyme activity
F168L
the variant has a lower relative activity than the wild type enzyme
K16N
the mutant shows wild type activity
K16N
the variant has a greater relative activity than the wild type enzyme
N156S
the mutant shows increased activity compared to the wild type enzyme
N156S
the mutation has a negative effect on the enzyme activity
N156S
the variant has a greater relative activity than the wild type enzyme
R131H
the mutant shows wild type activity
R131H
the mutation has a negative effect on the enzyme activity
R131H
the variant has a greater relative activity than the wild type enzyme
R199C
inactive
R199C
the mutation has a negative effect on the enzyme activity
R199C
the variant has a lower relative activity than the wild type enzyme
S17T
the mutant shows wild type activity
S17T
the mutation has a negative effect on the enzyme activity
S17T
the variant has a lower relative activity than the wild type enzyme
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Webster, L.T.; Siddiqui, U.A.; Lucas, S.V.; Strong, J.M.; Mieyal, J.J.
Identification of separate acyl-CoA:glycine and acyl-CoA:L-glutamine N-acyltransferase activities in mitochondrial fractions from liver of rhesus monkey and man
J. Biol. Chem.
251
3352-3358
1976
Homo sapiens, Macaca mulatta
brenda
Mawal, Y.R.; Qureshi, I.A.
An immunodetection method for the quantitation of human acyl CoA: glycine N-acyltransferase in biological samples
Biochem. Mol. Biol. Int.
34
595-601
1994
Ovis aries, Homo sapiens
brenda
Mawal, Y.R.; Qureshi, I.A.
Purification to homogeneity of mitochondrial acyl CoA: glycine N-acyltransferase from human liver
Biochem. Biophys. Res. Commun.
205
1373-1379
1994
Ovis aries, Homo sapiens
brenda
Mawal, Y.; Paradis, K.; Qureshi, I.A.
Developmental profile of mitochondrial glycine N-acyltransferase in human liver
J. Pediatr.
130
1003-1007
1997
Homo sapiens
brenda
Van der Westhuizen, F.H.; Pretorius, P.J.; Erasmus, E.
The utilization of alanine, glutamic acid, and serine as amino acid substrates for glycine N-acyltransferase
J. Biochem. Mol. Toxicol.
14
102-109
2000
Bos taurus, Homo sapiens
brenda
Zhang, H.; Lang, Q.; Li, J.; Zhong, Z.; Xie, F.; Ye, G.; Wan, B.; Yu, L.
Molecular cloning and characterization of a novel human glycine-N-acyltransferase gene GLYATL1, which activates transcriptional activity of HSE pathway
Int. J. Mol. Sci.
8
433-444
2007
Homo sapiens (Q969I3)
-
brenda
Yamamoto, A.; Nonen, S.; Fukuda, T.; Yamazaki, H.; Azuma, J.
Genetic polymorphisms of glycine N-acyltransferase in Japanese individuals
Drug Metab. Pharmacokinet.
24
114-117
2009
Homo sapiens (Q6IB77)
brenda
Matsuo, M.; Terai, K.; Kameda, N.; Matsumoto, A.; Kurokawa, Y.; Funase, Y.; Nishikawa, K.; Sugaya, N.; Hiruta, N.; Kishimoto, T.
Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma
Biochem. Biophys. Res. Commun.
420
901-906
2012
Homo sapiens (Q6IB77), Homo sapiens
brenda
Waluk, D.P.; Schultz, N.; Hunt, M.C.
Identification of glycine N-acyltransferase-like 2 (GLYATL2) as a transferase that produces N-acyl glycines in humans
FASEB J.
24
2795-2803
2010
Homo sapiens (Q8WU03)
brenda
Badenhorst, C.P.; van der Sluis, R.; Erasmus, E.; van Dijk, A.A.
Glycine conjugation: importance in metabolism, the role of glycine N-acyltransferase, and factors that influence interindividual variation
Expert. Opin. Drug Metab. Toxicol.
9
1139-1153
2013
Homo sapiens (Q6IB77)
brenda
Van der Sluis, R.; Badenhorst, C.; Van der Westhuizen, F.; Van Dijk, A.
Characterisation of the influence of genetic variations on the enzyme activity of a recombinant human glycine N-acyltransferase
Gene
515
447-453
2013
Homo sapiens (Q6IB77), Homo sapiens
brenda
van der Sluis, R.; Badenhorst, C.P.; Erasmus, E.; van Dyk, E.; van der Westhuizen, F.H.; van Dijk, A.A.
Conservation of the coding regions of the glycine N-acyltransferase gene further suggests that glycine conjugation is an essential detoxification pathway
Gene
571
126-134
2015
Homo sapiens (Q6IB77), Homo sapiens
brenda
van der Sluis, R.; Ungerer, V.; Nortje, C.; A van Dijk, A.; Erasmus, E.
New insights into the catalytic mechanism of human glycine N-acyltransferase
J. Biochem. Mol. Toxicol.
31
e21963
2017
Homo sapiens (Q6IB77), Homo sapiens
brenda
Eich, M.L.; Chandrashekar, D.S.; Rodriguez Pen A, M.D.C.; Robinson, A.D.; Siddiqui, J.; Daignault-Newton, S.; Chakravarthi, B.V.S.K.; Kunju, L.P.; Netto, G.J.; Varambally, S.
Characterization of glycine-N-acyltransferase like 1 (GLYATL1) in prostate cancer
Prostate
79
1629-1639
2019
Homo sapiens
brenda