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Literature summary for 2.3.1.13 extracted from
- The utilization of alanine, glutamic acid, and serine as amino acid substrates for glycine N-acyltransferase (2000), J. Biochem. Mol. Toxicol., 14, 102-109.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| benzoylglycine | competitive vs. benzoyl-CoA | Bos taurus |  |
| N-benzoyl-L-alanine | competitive vs. benzoyl-CoA | Bos taurus | |
| N-benzoyl-L-asparagine | competitive vs. benzoyl-CoA | Bos taurus | |
| N-benzoyl-L-glutamic acid | competitive vs. benzoyl-CoA | Bos taurus | |
| N-benzoyl-L-serine | competitive vs. benzoyl-CoA | Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 6.2 | - |
glycine | acyl donor benzoyl-CoA | Bos taurus | |
| 6.4 | - |
glycine | acyl donor benzoyl-CoA | Homo sapiens | |
| 13 | - |
benzoyl-CoA | cosubstrate glycine | Homo sapiens | |
| 15.2 | - |
benzoyl-CoA | cosubstrate alanine | Homo sapiens | |
| 41 | - |
benzoyl-CoA | cosubstrate alanine | Bos taurus | |
| 105 | - |
benzoyl-CoA | cosubstrate glutamine | Bos taurus | |
| 129 | - |
asparagine | acyl donor benzoyl-CoA | Bos taurus | |
| 157 | - |
benzoyl-CoA | cosubstrate asparagine | Bos taurus | |
| 160 | - |
benzoyl-CoA | cosubstrate glycine | Bos taurus | |
| 353 | - |
glutamine | acyl donor benzoyl-CoA | Bos taurus | |
| 997 | - |
alanine | acyl donor benzoyl-CoA | Homo sapiens | |
| 998 | - |
benzoyl-CoA | cosubstrate glutamic acid | Bos taurus | |
| 1150 | - |
glutamic acid | acyl donor benzoyl-CoA | Bos taurus | |
| 1573 | - |
alanine | acyl donor benzoyl-CoA | Bos taurus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 27000 | - |
27000, SDS-PAGE | Homo sapiens |
| 36000 | - |
1 * 36000, SDS-PAGE | Bos taurus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
- |
Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
| liver | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.7 | - |
- |
Homo sapiens |
| 9.7 | - |
- |
Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| benzoyl-CoA + L-alanine | - |
Homo sapiens | CoA + N-benzoyl-L-alanine | - |
? | |
| benzoyl-CoA + L-alanine | - |
Bos taurus | CoA + N-benzoyl-L-alanine | - |
? | |
| benzoyl-CoA + L-asparagine | - |
Homo sapiens | CoA + N-benzoyl-L-asparagine | - |
? | |
| benzoyl-CoA + L-asparagine | - |
Bos taurus | CoA + N-benzoyl-L-asparagine | - |
? | |
| benzoyl-CoA + L-glutamic acid | - |
Homo sapiens | CoA + N-benzoyl-L-glutamic acid | - |
? | |
| benzoyl-CoA + L-glutamic acid | - |
Bos taurus | CoA + N-benzoyl-L-glutamic acid | - |
? | |
| benzoyl-CoA + L-glutamine | - |
Homo sapiens | CoA + N-benzoyl-L-glutamine | - |
? | |
| benzoyl-CoA + L-glutamine | - |
Bos taurus | CoA + N-benzoyl-L-glutamine | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 36000, SDS-PAGE | Bos taurus |
| monomer | 27000, SDS-PAGE | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.1 | - |
N-benzoylglycine | - |
Bos taurus | |
| 3 | - |
N-benzoyl-L-asparagine | - |
Bos taurus | |
| 4.1 | - |
N-benzoyl-L-serine | - |
Bos taurus | |
| 7.9 | - |
N-benzoyl-L-alanine | - |
Bos taurus | |
| 8 | - |
N-benzoyl-L-glutamic acid | - |
Bos taurus | |
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Release 2023.1 (January 2023)
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