Protein Variants | Comment | Organism |
---|---|---|
E226Q | active site mutant | Homo sapiens |
F168L | the variant has a lower relative activity than the wild type enzyme | Homo sapiens |
K16N | the variant has a greater relative activity than the wild type enzyme | Homo sapiens |
N156S | the variant has a greater relative activity than the wild type enzyme | Homo sapiens |
R131H | the variant has a greater relative activity than the wild type enzyme | Homo sapiens |
R199C | the variant has a lower relative activity than the wild type enzyme | Homo sapiens |
S17T | the variant has a lower relative activity than the wild type enzyme | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + glycine | Homo sapiens | - |
CoA + N-acylglycine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q6IB77 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocellular carcinoma cell | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + glycine | - |
Homo sapiens | CoA + N-acylglycine | - |
? | |
benzoyl-CoA + glycine | - |
Homo sapiens | CoA + N-benzoylglycine | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | - |
Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
GlyAT | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme activity affects mitochondrial ATP production, glycine availability, free coenzyme A availability, and the toxicity of various organic acids | Homo sapiens |
physiological function | the enzyme plays a role in liver cancer and musculoskeletal development | Homo sapiens |