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2.3.3.17: methylthioalkylmalate synthase

This is an abbreviated version!
For detailed information about methylthioalkylmalate synthase, go to the full flat file.

Word Map on EC 2.3.3.17

Reaction

an omega-(methylsulfanyl)-2-oxoalkanoate
+
acetyl-CoA
 +
H2O
=
a 2-[omega-(methylsulfanyl)alkyl]malate
 +
CoA

Synonyms

MAM, MAM synthase, MAM1, MAM2, MAM3, MAMS, methylthioalkylmalate synthase 1, methylthioalkylmalate synthase1

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.3 Acyl groups converted into alkyl groups on transfer
                2.3.3.17 methylthioalkylmalate synthase

Substrates Products

Substrates Products on EC 2.3.3.17 - methylthioalkylmalate synthase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-oxo-4-methylthiobutanoate + acetyl-CoA + H2O
2-(2'-methylthio)ethylmalate + CoA
show the reaction diagram
-
-
-
?
2-oxoheptanoate + acetyl-CoA + H2O
2-pentylmalate + CoA
show the reaction diagram
84% activity compared to 5-methylthio-2-oxopentanoate
-
-
?
2-oxohexanoate + acetyl-CoA + H2O
2-butylmalate + CoA
show the reaction diagram
17% activity compared to 5-methylthio-2-oxopentanoate
-
-
?
2-oxoisovalerate + acetyl-CoA
isopropylmalate + CoA
show the reaction diagram
-
-
-
?
4-methyl-2-oxopentanoate + acetyl-CoA
?
show the reaction diagram
-
-
-
?
4-methylthio-2-oxobutanoate + acetyl-CoA + H2O
2-(2'-methylthioethyl)-malate + CoA
show the reaction diagram
-
-
-
?
4-methylthio-2-oxobutanoate + acetyl-CoA + H2O
2-(2'-methylthioethyl)malate + CoA
show the reaction diagram
4-methylthio-2-oxobutyrate + acetyl-CoA + H2O
2-(2'-methylthioethyl)malate + CoA
show the reaction diagram
-
-
-
?
5-methyl-2-oxohexanoate + acetyl-CoA
?
show the reaction diagram
-
-
-
?
5-methylthio-2-oxopentanoate + acetyl-CoA
?
show the reaction diagram
-
-
-
?
5-methylthio-2-oxopentanoate + acetyl-CoA + H2O
2-(3'-methylthiopropyl)malate + CoA
show the reaction diagram
5-methylthio-2-oxopentanoate + acetyl-CoA + H2O
?
show the reaction diagram
-
-
-
?
6-methylthio-2-oxohexanoate + acetyl-CoA + H2O
2-(4-methylthiobutyl)malate + CoA
show the reaction diagram
7-methylthio-2-oxoheptanoate + acetyl-CoA + H2O
2-(5-methylthiopentyl)malate + CoA
show the reaction diagram
substrate for isoform MAM3
-
-
?
8-methylthio-2-oxooctanoate + acetyl-CoA + H2O
2-(6-methylthiohexyl)malate + CoA
show the reaction diagram
9-methylthio-2-oxononanoate + acetyl-CoA
?
show the reaction diagram
-
-
-
?
9-methylthio-2-oxononanoate + acetyl-CoA + H2O
2-(7-methylthiohepyl)malate + CoA
show the reaction diagram
substrate for isoform MAM3
-
-
?
an omega-(methylthio)-2-oxoalkanoate + acetyl-CoA + H2O
a 2-[omega-(methylthio)alkyl]malate + CoA
show the reaction diagram
pyruvate + acetyl-CoA
citramalate + CoA
show the reaction diagram
-
-
-
?
additional information
?
-