2.3.3.17: methylthioalkylmalate synthase
This is an abbreviated version!
For detailed information about methylthioalkylmalate synthase, go to the full flat file.
Word Map on EC 2.3.3.17
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2.3.3.17
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glucosinolate
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isopropylmalate
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brassicaceae
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methionine-derived
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brassicae
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synthases
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methylene
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leu
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specialist
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ecotype
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branched-chain
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petraea
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oleracea
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condensing
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condenses
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acetyl-coenzyme
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lyrata
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generalist
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4-methylthio-2-oxobutyrate
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indole
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met-derived
- 2.3.3.17
- glucosinolate
- isopropylmalate
- brassicaceae
-
methionine-derived
- brassicae
- synthases
-
methylene
- leu
-
specialist
-
ecotype
-
branched-chain
- petraea
- oleracea
-
condensing
-
condenses
-
acetyl-coenzyme
- lyrata
-
generalist
- 4-methylthio-2-oxobutyrate
- indole
-
met-derived
Reaction
Synonyms
MAM, MAM synthase, MAM1, MAM2, MAM3, MAMS, methylthioalkylmalate synthase 1, methylthioalkylmalate synthase1
ECTree
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Engineering on EC 2.3.3.17 - methylthioalkylmalate synthase
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
A290G
the strain harbouring the MAM1 variant produces more thrice-elongated methionine than the native MAM1
A290S
unchanged composition of chain-elongated amino acids. The strain harbouring the MAM1 variant produces more thrice-elongated methionine than the native MAM1
A290T
G259A
T257C
the strain harbouring the MAM1 variant produces more thrice-elongated methionine than the native MAM1
T257D
in the strain harbouring the MAM1 variant, SSU3 protein level is higher than in the strain harbouring wild-type MAM1. The strain harbouring the MAM1 variant produces more thrice-elongated methionine than the native MAM1
T257G
the strain harbouring the MAM1 variant does not produce amino acids elongated more than twice
T257G/G259A
the strain harbouring the MAM1 variant produces tetra-elongated methionine
T257G/G259A/A290G
the strain harbouring the MAM1 variant produces tetra-elongated methionine. Unchanged composition of chain-elongated amino acids, although the production is dramatically reduced
T257G/G259A/L186M
the strain harbouring the MAM1 variant produces tetra-elongated methionine
T257N
T257S shows nearly 3fold higher L-homophenylalanine production than the native MAM1. In the strain harbouring the MAM1 variant, SSU3 protein level is higher than in the strain harbouring wild-type MAM1. Low levels of chain-elongated amino acid products are found
T257S
the strain harbouring the MAM1 variant shows higher MAM1 levels, although this does not result in correspondingly higher levels of chain-elongated products
A290T
in the strain harbouring the MAM1 variant, SSU3 protein level is higher than in the strain harbouring wild-type MAM1. No chain-elongated amino acid products are found
A290T
the strain harbouring the MAM1 variant does not produce any of the chain-elongated amino acid products
G259A
in the strain harbouring the MAM1 variant, SSU3 protein level is higher than in the strain harbouring wild-type MAM1. No chain-elongated amino acid products are found
G259A
the strain harbouring the MAM1 variant does not produce amino acids elongated more than twice
G259A
the strain harbouring the MAM1 variant does not produce any of the chain-elongated amino acid products
