Sequence of SIBG_STRSJ
EC Number:1.14.13.223
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] 5-monooxygenase
C0LTM1
Streptosporangium sibiricum
351
38088
Reaction
3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + NADH + H+ + O2 = 3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + NAD+ + H2O
Other sequences found for EC No. 1.14.13.223
General information:
Sequence
0 MRILVNGGGP AGMAFAMFAA RSGRGDEITV RDWTGPGDTY GFGVILPPAA VEVFRDAEPD
60 LADELNSHIT AWDRLSVHRH GRTASIPAPR LGAMDRRTLL KVLRRRCAER GVRFEHGAVD
120 PALGDHDLVV AADGARSVTR RHRAAAFGTT TREIGPAYIW LGADRALEHL RFLVAETPDG
180 PAVAHAYPYS PDRSTFLVEA DGAPPPAVLA EWFAGPLGGA RLLENRSRWS RFQEIHNRTW
240 SAGNVVLIGD AAHTAHYSIG SGTRLALDDA RALADALCAQ PRLADALKGY EDARRPIVEH
300 TQRIGRLSAT WFTRLPDVPM ERLLDDLATR GGQISWRDLA TEGSGAVPVR G
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
483428
Li W.,Khullar A.,Chou S.,Sacramo A.,Gerratana B.
Biosynthesis of sibiromycin, a potent antitumor antibiotic.
Appl. Environ. Microbiol.
75
2869-2878
2009
483429
Giessen T.W.,Kraas F.I.,Marahiel M.A.
A four-enzyme pathway for 3,5-dihydroxy-4-methylanthranilic acid formation and incorporation into the antitumor antibiotic sibiromycin.
Biochemistry
50
5680-5692
2011
