Sequence of CED3_CAEEL

caspase-7

P42573

503

56617

400238

Yuan J.,Shaham S.,Ledoux S.,Ellis H.M.,Horvitz H.R.

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme.

Cell

75

641-652

1993

400240

Genome sequence of the nematode C. elegans: a platform for investigating biology.

Science

282

2012-2018

1998

400241

Xue D.,Shaham S.,Horvitz H.R.

The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease.

Genes Dev.

10

1073-1083

1996

400242

Ellis H.M.,Horvitz H.R.

Genetic control of programmed cell death in the nematode C. elegans.

Cell

44

817-829

1986

400243

Shaham S.

Identification of multiple Caenorhabditis elegans caspases and their potential roles in proteolytic cascades.

J. Biol. Chem.

273

35109-35117

1998

400244

Gumienny T.L.,Lambie E.,Hartwieg E.,Horvitz H.R.,Hengartner M.O.

Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline.

Development

126

1011-1022

1999

400245

Wu D.,Chen P.J.,Chen S.,Hu Y.,Nunez G.,Ellis R.E.

C. elegans MAC-1, an essential member of the AAA family of ATPases, can bind CED-4 and prevent cell death.

Development

126

2021-2031

1999

400246

Chan S.L.,Yee K.S.,Tan K.M.,Yu V.C.

The Caenorhabditis elegans sex determination protein FEM-1 is a CED-3 substrate that associates with CED-4 and mediates apoptosis in mammalian cells.

J. Biol. Chem.

275

17925-17928

2000

400247

Cizeau J.,Ray R.,Chen G.,Gietz R.D.,Greenberg A.H.

The C. elegans orthologue ceBNIP3 interacts with CED-9 and CED-3 but kills through a BH3- and caspase-independent mechanism.

Oncogene

19

5453-5463

2000

400248

Aballay A.,Ausubel F.M.

Programmed cell death mediated by ced-3 and ced-4 protects Caenorhabditis elegans from Salmonella typhimurium-mediated killing.

Proc. Natl. Acad. Sci. U.S.A.

98

2735-2739

2001

400249

Maurer C.W.,Chiorazzi M.,Shaham S.

Timing of the onset of a developmental cell death is controlled by transcriptional induction of the C. elegans ced-3 caspase-encoding gene.

Development

134

1357-1368

2007

400250

Taylor R.C.,Brumatti G.,Ito S.,Hengartner M.O.,Derry W.B.,Martin S.J.

Establishing a blueprint for CED-3-dependent killing through identification of multiple substrates for this protease.

J. Biol. Chem.

282

15011-15021

2007

400251

Breckenridge D.G.,Kang B.H.,Kokel D.,Mitani S.,Staehelin L.A.,Xue D.

Caenorhabditis elegans drp-1 and fis-2 regulate distinct cell-death execution pathways downstream of ced-3 and independent of ced-9.

Mol. Cell

31

586-597

2008

400252

Geng X.,Shi Y.,Nakagawa A.,Yoshina S.,Mitani S.,Shi Y.,Xue D.

Inhibition of CED-3 zymogen activation and apoptosis in Caenorhabditis elegans by caspase homolog CSP-3.

Nat. Struct. Mol. Biol.

15

1094-1101

2008

400253

Geng X.,Zhou Q.H.,Kage-Nakadai E.,Shi Y.,Yan N.,Mitani S.,Xue D.

Caenorhabditis elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells.

Cell Death Differ.

16

1385-1394

2009

400254

Qi S.,Pang Y.,Hu Q.,Liu Q.,Li H.,Zhou Y.,He T.,Liang Q.,Liu Y.,Yuan X.,Luo G.,Li H.,Wang J.,Yan N.,Shi Y.

Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4.

Cell

141

446-457

2010

400255

Nakagawa A.,Shi Y.,Kage-Nakadai E.,Mitani S.,Xue D.

Caspase-dependent conversion of Dicer ribonuclease into a death-promoting deoxyribonuclease.

Science

328

327-334

2010

400256

Rutkowski R.,Dickinson R.,Stewart G.,Craig A.,Schimpl M.,Keyse S.M.,Gartner A.

Regulation of Caenorhabditis elegans p53/CEP-1-dependent germ cell apoptosis by Ras/MAPK signaling.

PLoS Genet.

7

0-0

2011

400257

Contreras V.,Friday A.J.,Morrison J.K.,Hao E.,Keiper B.D.

Cap-independent translation promotes C. elegans germ cell apoptosis through Apaf-1/CED-4 in a caspase-dependent mechanism.

PLoS ONE

6

0-0

2011

400258

Pinan-Lucarre B.,Gabel C.V.,Reina C.P.,Hulme S.E.,Shevkoplyas S.S.,Slone R.D.,Xue J.,Qiao Y.,Weisberg S.,Roodhouse K.,Sun L.,Whitesides G.M.,Samuel A.,Driscoll M.

The core apoptotic executioner proteins CED-3 and CED-4 promote initiation of neuronal regeneration in Caenorhabditis elegans.

PLoS Biol.

10

0-0

2012

400259

Chen Y.Z.,Mapes J.,Lee E.S.,Skeen-Gaar R.R.,Xue D.

Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalization.

Nat. Commun.

4

2726-2726

2013

400260

Weaver B.P.,Zabinsky R.,Weaver Y.M.,Lee E.S.,Xue D.,Han M.

CED-3 caspase acts with miRNAs to regulate non-apoptotic gene expression dynamics for robust development in C. elegans.

Elife

3

0-0

2014

400261

Nakagawa A.,Sullivan K.D.,Xue D.

Caspase-activated phosphoinositide binding by CNT-1 promotes apoptosis by inhibiting the AKT pathway.

Nat. Struct. Mol. Biol.

21

1082-1090

2014

400262

Meng L.,Mulcahy B.,Cook S.J.,Neubauer M.,Wan A.,Jin Y.,Yan D.

The cell death pathway regulates synapse elimination through cleavage of gelsolin in Caenorhabditis elegans neurons.

Cell Rep.

11

1737-1748

2015

400263

Chen X.,Wang Y.,Chen Y.Z.,Harry B.L.,Nakagawa A.,Lee E.S.,Guo H.,Xue D.

Regulation of CED-3 caspase localization and activation by C. elegans nuclear-membrane protein NPP-14.

Nat. Struct. Mol. Biol.

23

958-964

2016

400264

Weaver B.P.,Weaver Y.M.,Mitani S.,Han M.

Coupled Caspase and N-End Rule Ligase Activities Allow Recognition and Degradation of Pluripotency Factor LIN-28 during Non-Apoptotic Development.

Dev. Cell

41

665-673

2017

400265

Huang W.,Jiang T.,Choi W.,Qi S.,Pang Y.,Hu Q.,Xu Y.,Gong X.,Jeffrey P.D.,Wang J.,Shi Y.

Mechanistic insights into CED-4-mediated activation of CED-3.

Genes Dev.

27

2039-2048

2013