Sequence of CP11A_BOVIN
EC Number:1.14.15.6
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
(20R,22R)-20,22-dihydroxy-cholesterol + 2 reduced adrenodoxin + O2 + 2 H+ = pregnenolone + 4-methylpentanal + 2 oxidized adrenodoxin + 2 H2O
Other sequences found for EC No. 1.14.15.6
General information:
Sequence
0 MLARGLPLRS ALVKACPPIL STVGEGWGHH RVGTGEGAGI STKTPRPYSE IPSPGDNGWL
60 NLYHFWREKG SQRIHFRHIE NFQKYGPIYR EKLGNLESVY IIHPEDVAHL FKFEGSYPER
120 YDIPPWLAYH RYYQKPIGVL FKKSGTWKKD RVVLNTEVMA PEAIKNFIPL LNPVSQDFVS
180 LLHKRIKQQG SGKFVGDIKE DLFHFAFESI TNVMFGERLG MLEETVNPEA QKFIDAVYKM
240 FHTSVPLLNV PPELYRLFRT KTWRDHVAAW DTIFNKAEKY TEIFYQDLRR KTEFRNYPGI
300 LYCLLKSEKM LLEDVKANIT EMLAGGVNTT SMTLQWHLYE MARSLNVQEM LREEVLNARR
360 QAEGDISKML QMVPLLKASI KETLRLHPIS VTLQRYPESD LVLQDYLIPA KTLVQVAIYA
420 MGRDPAFFSS PDKFDPTRWL SKDKDLIHFR NLGFGWGVRQ CVGRRIAELE MTLFLIHILE
480 NFKVEMQHIG DVDTIFNLIL TPDKPIFLVF RPFNQDPPQA
Download this sequence
in fasta formatDownload all sequences for 1.14.15.6
in fasta format
in csv (Excel, OpenOffice) formatSequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
279175
Morohashi K.,Fujii-Kuriyama Y.,Okada Y.,Sogawa K.,Hirose T.,Inayama S.,Omura T.
Molecular cloning and nucleotide sequence of cDNA for mRNA of mitochondrial cytochrome P-450(SCC) of bovine adrenal cortex.
Proc. Natl. Acad. Sci. U.S.A.
81
4647-4651
1984
279176
Chashchin V.L.,Lapko V.N.,Adamovich T.B.,Lapko A.G.,Kuprina N.S.,Akhrem A.A.
Primary structure of the cholesterol side-chain cleavage cytochrome P-450 from bovine adrenocortical mitochondria and some aspects of its functioning on a structural level.
Biochim. Biophys. Acta
871
217-223
1986
279177
Ogishima T.,Okada Y.,Kominami S.,Takemori S.,Omura T.
Partial amino acid sequences of two mitochondrial and two microsomal cytochrome P-450's from adrenal cortex.
J. Biochem.
94
1711-1714
1983
279178
Ahlgren R.,Simpson E.R.,Waterman M.R.,Lund J.
Characterization of the promoter/regulatory region of the bovine CYP11A (P-450scc) gene. Basal and cAMP-dependent expression.
J. Biol. Chem.
265
3313-3319
1990
279179
Hanukoglu I.,Hanukoglu Z.
Stoichiometry of mitochondrial cytochromes P-450, adrenodoxin and adrenodoxin reductase in adrenal cortex and corpus luteum. Implications for membrane organization and gene regulation.
Eur. J. Biochem.
157
27-31
1986
279180
Vijayakumar S.,Salerno J.C.
Molecular modeling of the 3-D structure of cytochrome P-450scc.
Biochim. Biophys. Acta
1160
281-286
1992
279181
Pikuleva I.A.,Puchkaev A.,Bjoerkhem I.
Putative helix F contributes to regioselectivity of hydroxylation in mitochondrial cytochrome P450 27A1.
Biochemistry
40
7621-7629
2001
279182
Mast N.,Annalora A.J.,Lodowski D.T.,Palczewski K.,Stout C.D.,Pikuleva I.A.
Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1.
J. Biol. Chem.
286
5607-5613
2011
