Sequence of POLG_BVDVS
EC Number:3.4.21.113
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
pestivirus NS3 polyprotein peptidase
Q01499
Bovine viral diarrhea virus (strain SD-1)
3898
437808
Reaction
Leu is conserved at position P1 for all four cleavage sites. Alanine is found at position P1' of the NS4A-NS4B cleavage site, whereas serine is found at position P1' of the NS3-NS4A, NS4B-NS5A and NS5A-NS5B cleavage sites
Other sequences found for EC No. 3.4.21.113
General information:
Sequence
0 MELITNELLY KTYKQKPVGV EEPVYDQAGN PLFGERGAIH PQSTLKLPHK RGERNVPTSL
60 ASLPKRGDCR SGNSKGPVSG IYLKPGPLFY QDYKGPVYHR APLELFEEGS MCETTKRIGR
120 VTGSDGKLYH IYICIDGCIT VKSATRSHQR VLRWVHNRLD CPLWVTSCSD TKEEGATKKK
180 QQKPDRLEKG RMKIVPKESE KDSKTKPPDA TIVVDGVKYQ VKKKGKVKSK NTQDGLYHNK
240 NKPPESRKKL EKALLAWAIL AVVLIEVTMG ENITQWNLQD NGTEGIQRAM FQRGVNRSLH
300 GIWPEKICTG VPSHLATDVE LKTIHGMMDA SEKTNYTCCR LQRHEWNKHG WCNWYNIEPW
360 ILIMNRTQAN LTEGQPPREC AVTCRYDRDS DLNVVTQARD SPTPLTGCKK GKNFSFAGVL
420 TRGPCNFEIA ASDVLFKEHE CTGVFQDTAH YLVDGVTNSL ESARQGTAKL TTWLGKQLGI
480 LGKKLENKSK TWFGAYAASP YCDVDRKIGY IWFTKNCTPA CLPKNTKIIG PGKFDTNAED
540 GKILHEMGGH LSEVLLLSLV VLSDFAPETA SAMYLILHFS IPQSHVDITD CDKTQLNLTI
600 ELTTADVIPG SVWNLGKYVC IRPDWWPYET AAVLAFEEVG QVVKIVLRAL RDLTRIWNAA
660 TTTAFLVCLI KMVRGQVVQG ILWLLLITGV QGHLDCKPEY SYAIAKNDRV GPLGAEGLTT
720 VWKDYSHEMK LEDTMVIAWC KGGKFTYLSR CTRETRYLAI LHSRALPTSV VFKKLFEGQK
780 QEDTVEMDDD FEFGLCPCDA KPIVRGKFNT TLLNGPAFQM VCPIGWTGTV SCMLANRDTL
840 DTAVVRTYRR SVPFPYRQGC ITQKTLGEDL YDCALGGNWT CVTGDQSRYT GGLIESCKWC
900 GYKFQKSEGL PHYPIGKCRL NNETGYRLVD DTSCDREGVA IVPHGLVKCK IGDTTVQVIA
960 TDTKLGPMPC KPHEIISSEG PIEKTACTFN YTRTLKNKYF EPRDSYFQQY MLKGDYQYWF
1020 DLEVTDHHRD YFAESILVVV VALLGGRYVL WLLVTYMVLS EQKASGAQYG AGEVVMMGNL
1080 LTHDNVEVVT YFFLLYLLLR EESVKKWVLL LYHILVAHPL KSVIVILLMI GDVVKADPGG
1140 QGYLGQIDVC FTMVVIIIIG LIIARRDPTI VPLITIVASL RVTGLTYSPG VDAAMAVITI
1200 TLLMVSYVTD YFRYKRWLQC ILSLVSGVFL IRCLIHLGRI ETPEVTIPNW RPLTLILFYL
1260 ISTTVVTMWK IDLAGLLLQG VPILLLITTL WADFLTLILI LPTYELVKLY YLKTIKTDIE
1320 KSWLGGLDYK RVDSIYDVDE SGEGVYLFPS RQKAQKNFSM LLPLVRATLI SCVSSKWQLI
1380 YMAYLSVDFM YYMHRKVIEE ISGGTNMISR IVAALIELNW SMEEEESKGL KKFYLLSGRL
1440 RNLIIKHKVR NETVAGWYGE EEVYGMPKIM TIIKASTLNK NKHCIICTVC EGRKWKGGTC
1500 PKCGRHGKPI TCGMSLADFE ERHYKRIFIR EGNFEGPFRQ EYNGFIQYTA RGQLFLRNLP
1560 ILATKVKMLM VGNLGEEVGD LEHLGWILRG PAVCKKITEH ERCHINILDK LTAFFGIMPR
1620 GTTPRAPVRF PTSLLKVRRG LETGWAYTHQ GGISSVDHVT AGKDLLVCDS MGRTRVVCQS
1680 NNKLTDETEY GVKTDSGCPD GARCYVLNPE AVNISGSKGA VVHLQKTGGE FTCVTASGTP
1740 AFFDLKNLKG WSGLPIFEAS SGRVVGRVKV GKNEESKPTK IMSGIQTVSK NTADLTEMVK
1800 KITSMNRGDF KQITLATGAG KTTELPKAVI EEIGRHKRVL VLIPLRAAAE SVYQYMRLKH
1860 PSISFNLRIG DMKEGDMATG ITYASYGYFC QMPQPKLRAA MVEYSYIFLD EYHCATPEQL
1920 AIIGKIHRFS ESIRVVAMTA TPAGSVTTTG QKHPIEEFIA PEVMEGEDLG SQFLDIAGLK
1980 IPVDEMKGNM LVFVPTRNMA VEVAKKLKAK GYNSGYYYSG EDPANLRVVT SQSPYVIVAT
2040 NAIESGVTLP DLDTVVDTGL KCEKRVRVSS KIPFIVTGLK RMAVTVGEQA QRRGRVGRVK
2100 PGRYYRSQET ATGSKDYHYD LLQAQRYGIE DGINVTKSFR EMNYDWSLYE EDSLLITQLE
2160 ILNNLLISED LPAAVKNIMA RTDHPEPIQL AYNSYEVQVP VLFPKIRNGE VTDTYENYSF
2220 LNARKLGEDV PVYIYATEDE DLAVDLLGLD WPDPGNQQVV ETGKALKQVA GLSSAENALL
2280 VALFGYVGYQ ALSKRHVPMI TDIYTIEDQR LEDTTHLQYA PNAIKTEGTE TELKELASGD
2340 VEKIMGAISD YAAGGLDFVK SQAEKIKTAP LFKENVEAAR GYVQKLIDSL IEDKDVIIRY
2400 GLWGTHTALY KSIAARLGHE TAFATLVLKW LAFGGETVSD HIRQAAVDLV VYYVMNKPSF
2460 PGDTETQQEG RRFVASLFIS ALATYTYKTW NYNNLSKVVE PALAYLPYAT SALKMFTPTR
2520 LESVVILSTT IYKTYLSIRK GKSDGLLGTG ISAAMEILSQ NPVSVGISVM LGVGAIAAHN
2580 AIESSEQKRT LLMKVFVKNF LDQAATDELV KENPEKIIMA LFEAVQTIGN PLRLIYHLYG
2640 VYYKGWEAKE LSERTAGRNL FTLIMFEAFE LLGMDSEGKI RNLSGNYILD LIHGLHKQIN
2700 RGLKKIVLGW APAPFSCDWT PSDERIRLPT DSYLRVETKC PCGYEMKALK NVSGKLTKVE
2760 ESGPFLCRNR PGRGPVNYRV TKYYDDNLRE IRPVAKLEGQ VEHYYKGVTA RIDYSKGKTL
2820 LATDKWEVEH GTLTRLTKRY TGVGFRGAYL GDEPNHRDLV ERDCATITKN TVQFLKMKKG
2880 CAFTYDLTIS NLTRLIELVH RNNLEEKEIP TATVTTWLAY TFVNEDVGTI KPVLGERVIP
2940 DPVVDINLQP EVQVDTSEVG ITIIGKEAVM TTGVTPVMEK VEPDTDNNQS SVKIGLDEGN
3000 YPGPGVQTHT LVEEIHNKDA RPFIMVLGSK SSMSNRAKTA RNINLYTGND PREIRDLMAE
3060 GRILVVALRD IDPDLSELVD FKGTFLDREA LEALSLGQPK PKQVTKAAIR DLLKEERQVE
3120 IPDWFTSDDP VFLDIAMKKD KYHLIGDVVE VKDQAKALGA TDQTRIVKEV GSRTYTMKLS
3180 SWFLQASSKQ MSLTPLFEEL LLRCPPATKS NKGHMASAYQ LAQGNWEPLG CGVHLGTVPA
3240 RRVKMHPYEA YLKLKDLVEE EEKKPRIRDT VIREHNKWIL KKIKFQGNLN TKKMLNPGKL
3300 SEQLDREGHK RNIYNNQIST VMSSAGIRLE KLPIVRAQTD TKSFHEAIRD KIDKNENRQN
3360 PELHNKLLEI FHTIADPSLK HTYGEVTWEQ LEAGINRKGA AGFLEKKNIG EVLDSEKHLV
3420 EQLVRDLKAG RKIRYYETAI PKNEKRDVSD DWQAGDLVDE KKPRVIQYPE AKTRLAITKV
3480 MYNWVKQQPV VIPGYEGKTP LFNIFNKVRK EWDLFNEPVA VSFDTKAWDT QVTSRDLHLI
3540 GEIQKYYYRK EWHKFIDTIT DHMVEVPVIT ADGEVYIRNG QRGSGQPDTS AGNSMLNVLT
3600 MIYAFCESTG VPYKSFNRVA KIHVCGDDGF LITEKGLGLK FSNKGMQILH EAGKPQKLTE
3660 GEKMKVAYKF EDIEFCSHTP VPVRWSDNTS SYMAGRDTAV ILSKMATRLD SSGERGTTAY
3720 EKAVAFSFLL MYSWNPLVRR ICLLVLSQRP ETAPSTQTTY YYKGDPIGAY KDVIGRNLSE
3780 LKRTGFEKLA NLNLSLSTLG IWTKHTSKRI IQDCVAIGKE EGNWLVNADR LISSKTGHLY
3840 IPDKGFTLQG KHYEQLQLGA ETNPVMGVGT ERYKLGPIVN LLLRRLKVLL MAAVGASS
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
207423
Deng R.,Brock K.V.
Molecular cloning and nucleotide sequence of a pestivirus genome, noncytopathic bovine viral diarrhea virus strain SD-1.
Virology
191
867-869
1992
