Sequence of POLG_BVDVC
EC Number:3.4.21.113
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
pestivirus NS3 polyprotein peptidase
Q96662
Bovine viral diarrhea virus (strain CP7)
3907
439104
Reaction
Leu is conserved at position P1 for all four cleavage sites. Alanine is found at position P1' of the NS4A-NS4B cleavage site, whereas serine is found at position P1' of the NS3-NS4A, NS4B-NS5A and NS5A-NS5B cleavage sites
Other sequences found for EC No. 3.4.21.113
General information:
Sequence
0 MELITNELLY KTYKQKPAGV EEPVYDQAGN PLFGERGVIH PQSTLKLPHK RGEREVPTNL
60 ASLPKRGDCR SGNSKGPVSG IYLKPGPLFY QDYKGPVYHR APLEFFEEAS MCETTKRIGR
120 VTGSDSRLYH IYVCIDGCII VKSATKDRQK VLKWVHNKLN CPLWVSSCSD TKDEGVVRKK
180 QQKPDRLEKG RMKITPKESE KDSKTKPPDA TIVVDGVKYQ VKKKGKVKSK NTQDGLYHNK
240 NKPQESRKKL EKALLAWAII ALVFFQVTMG ENITQWNLQD NGTEGIQRAM FQRGVNRSLH
300 GIWPEKICTG VPSHLATDTE LKAIHGMMDA SEKTNYTCCR LQRHEWNKHG WCNWYNIEPW
360 ILLMNKTQAN LTEGQPLREC AVTCRYDRDS DLNVVTQARD SPTPLTGCKK GKNFSFAGIL
420 VQGPCNFEIA VSDVLFKEHD CTSVIQDTAH YLVDGMTNSL ESARQGTAKL TTWLGRQLGI
480 LGKKLENKSK TWFGAYAASP YCEVERKLGY IWYTKNCTPA CLPRNTKIIG PGRFDTNAED
540 GKILHEMGGH LSEVLLLSVV VLSDFAPETA SVIYLILHFS IPQGHTDIQD CDKNQLNLTV
600 ELTTAEVIPG SVWNLGKYVC VRPDWWPYET ATVLVIEEVG QVIKVVLRAL KDLTRIWTAA
660 TTTAFLVCLV KVVRGQVLQG ILWLMLITGA QGYPDCKPGF SYAIAKNDEI GPLGATGLTT
720 QWYEYSDGMR LQDSVVEVWC KNGEIKYLIR CGREARYLAV LHTRALPTSV VFEKIFDGKE
780 QEDIVEMDDN FEFGLCPCDA RPLIRGKFNT TLLNGPAFQM VCPIGWTGTV SCTLANKDTL
840 ATIVVRTYKR VRPFPYRQDC VTQKTIGEDL YDCALGGNWT CVPGDALRYV AGPVESCEWC
900 GYKFLKSEGL PHFPIGKCRL KNESGYRQVD ETSCNRNGVA IVPSGTVKCK IGDTVVQVIA
960 MDDKLGPMPC KPHEIISSEG PVEKTACTFN YTRTLKNKYF EPRDNYFQQY MLKGEYQYWF
1020 DLEITDHHRD YFAESLLVIV VALLGGRYVL WLLVTYMILS EQMASGVQYG AGEIVMMGNL
1080 LTHDSVEVVT YFLLLYLLLR EENTKKWVIL IYHIIVMHPL KSVTVILLMV GGMAKAEPGA
1140 QGYLEQVDLS FTMITIIVIG LVIARRDPTV VPLVTIVAAL KITGLGFGPG VDAAMAVLTL
1200 TLLMTSYVTD YFRYKRWIQC ILSLVAGVFL IRTLKHLGEL KTPELTIPNW RPLTFILLYL
1260 TSATVVTRWK IDIAGIFLQG APILLMIATL WADFLTLVLI LPTYELAKLY YLKNVKTDVE
1320 KSWGVPYPDP QTLGGLDYRT IDSVYDVDES GEGVYLFPSR QKKNKNISIL LPLIRATLIS
1380 CISSKWQMVY MAYLTLDFMY YMHRKVIEEI SGSTNVMSRV IAALIELNWS MEEEESKGLK
1440 KFFILSGRLR NLIIKHKVRN QTVASWYGEE EVYGMPKVVT IIRACTLNKN KHCIICTVCE
1500 ARKWKGGNCP KCGRHGKPII CGMTLADFEE RHYKRIFIRE GNFEGPFRQE YNGFVQYTAR
1560 GQLFLRNLPI LATKVKMIMV GNLGEEIGDL EHLGWILRGP AVCKKITEHE KCHVNILDKL
1620 TAFFGVMPRG TTPRAPVRFP TALLKVRRGL ETGWAYTHQG GISSVDHVTA GKDLLVCDSM
1680 GRTRVVCQSN NKLTDETEYG VKTDSGCPDG ARCYVLNPEA VNISGSKGAV VHLQKTGGEF
1740 TCVTASGTPA FFDLKNLKGW SGLPIFEASS GRVVGRVKVG KNEESKPTKL MSGIQTVSKN
1800 TADLTEMVKK ITSMNRGDFR QITLATGAGK TTELPKAVIE EIGRHKRVLV LIPLRAAAES
1860 VYQYMRLKHP SISFNLRIGD MKEGDMATGI TYASYGYFCQ MPQPKLRAAM IEYSYIFLDE
1920 YHCATPEQLA VIGKIHRFSE SIRVVAMTAT PAGSVTTTGQ KHPIEEFIAP EVMKGEDLGS
1980 QFLDIAGLKI PVEEMKGNML VFVPTRNMAV EVAKKLKAKG YNSGYYYSGE DPANLRVVTS
2040 QSPYVVVATN AIESGVTLPD LDTVVDTGLK CEKRVRVSSK IPFIVTGLKR MAVTVGEQAQ
2100 RRGRVGRVKP GRYYRSQETA TGSKDYHYDL LQAQRYGIED GINVTKSFRE MNYDWSLYEE
2160 DSLLITQLEI LNNLLISEDL PAAVKNIMAR TDHPEPIQLA YNSYEVQVPV LFPKIRNGEV
2220 TDTYENYSFL NARKLGEDVP VYVYATEDED LAVDLLGLDW PDPGNQQVVE TGKALKQVVG
2280 LSSAENALLI ALFGYVGYQA LSKRHVPMIT DIYTIEDQRL EDTTHLQYAP NAIRTEGKET
2340 ELKELAVGDL DKIMGSISDY ASEGLNFVRS QAEKMRSAPA FKENVEAAKG YVQKFIDSLI
2400 ENKETIIRYG LWGTHTALYK SIAARLGHET AFATLVIKWL AFGGESVSDH MRQAAVDLVV
2460 YYVINKPSFP GDSETQQEGR RFVASLFISA LATYTYKTWN YNNLSKVVEP ALAYLPYATN
2520 ALKMFTPTRL ESVVILSTTI YKTYLSIRKG KSDGLLGTGI SAAMEILSQN PVSVGISVML
2580 GVGAIAAHNA IESSEQKRTL LMKVFVKNFL DQAATDELVK ENPEKIIMAL FEAVQTIGNP
2640 LRLIYHLYGV YYKGWEAKEL SERTAGRNLF TLIMFEAFEL LGMDSEGKIR NLSGNYVLDL
2700 IYSLHKQINR GLKKIVLGWA PAPFSCDWTP SDERIRLPTN NYLRVETKCP CGYEMKALRN
2760 VGGSLTKVEE KGPFLCRNRL GRGPVNYRVT KYYDDNLKEI KPVAKLEGFV DHYYKGVTAR
2820 IDYGRGKMLL ATDKWEVEHG VVTRLAKRYT GVGFKGAYLG DEPNHRDLVE RDCATITKNT
2880 VQFLKMKKGC AFTYDLTLSN LTRLIELVHK NNLEEKDIPA ATVTTWLAYT FVNEDIGTIK
2940 PVLGERVVTD PVVDVNLQPE VQVDTSEVGI TLVGRAALMT TGTTPVVEKT EPNADGGPSS
3000 IKIGLDEGRY PGPGLQDRTL TDEIHSRDER PFVLVLGSKN SMSNRAKTAR NINLYKGNNP
3060 REIRDLMAQG RMLVVALKDF NPELSELVDF KGTFLDREAL EALSLGRPKS KQVTTATVRE
3120 LLEQEVQVEI PSWFGAGDPV FLEVTLKGDR YHLVGDVDRV KDQAKELGAT DQTRIVKEVG
3180 ARTYTMKLSS WFLQATNKQM SLTPLFEELL LRCPPKIKSN KGHMASAYQL AQGNWEPLDC
3240 GVHLGTIPAR RVKIHPYEAY LKLKDLLEEE EKKPKCRDTV IREHNKWILK KVRHQGNLNT
3300 KKILNPGKLS EQLDREGHKR NIYNNQIGTI MTEAGSRLEK LPVVRAQTDT KSFHEAIRDK
3360 IDKNENQQSP GLHDKLLEIF HTIAQPSLRH TYSDVTWEQL EAGVNRKGAA GFLEKKNVGE
3420 VLDSEKHLVE QLIRDLKTGR KIRYYETAIP KNEKRDVSDD WQSGDLVDEK KPRVIQYPEA
3480 KTRLAITKVM YNWVKQQPVV IPGYEGKTPL FNIFNKVRKE WDLFNEPVAV SFDTKAWDTQ
3540 VTSRDLRLIG EIQKYYYRKE WHKFIDTITD HMVEVPVITA DGEVYIRNGQ RGSGQPDTSA
3600 GNSMLNVLTM MYAFCESTGV PYKSFNRVAR IHVCGDDGFL ITEKGLGLKF ANNGMQILHE
3660 AGKPQKITEG ERMKVAYRFE DIEFCSHTPV PVRWSDNTSS YMAGRDTAVI LSKMATRLDS
3720 SGERGTIAYE KAVAFSFLLM YSWNPLVRRI CLLVLSQQPE TTPSTQTTYY YKGDPIGAYK
3780 DVIGKNLCEL KRTGFEKLAN LNLSLSTLGI WSKHTSKRII QDCVTIGKEE GNWLVNADRL
3840 ISSKTGHLYI PDKGYTLQGK HYEQLQLQAR TSPVTGVGTE RYKLGPIVNL LLRRLRVLLM
3900 AAVGASS
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
207407
Meyers G.,Tautz N.,Becher P.,Thiel H.,Kuemmerer B.M.
Recovery of cytopathogenic and noncytopathogenic bovine viral diarrhea viruses from cDNA constructs.
J. Virol.
70
8606-8613
1996
207408
Becher P.,Orlich M.,Thiel H.-J.
Mutations in the 5' nontranslated region of bovine viral diarrhea virus result in altered growth characteristics.
J. Virol.
74
7884-7894
2000
207409
Elbers K.,Tautz N.,Becher P.,Stoll D.,Ruemenapf T.,Thiel H.-J.
Processing in the pestivirus E2-NS2 region: identification of proteins p7 and E2p7.
J. Virol.
70
4131-4135
1996
207410
Tautz N.,Elbers K.,Stoll D.,Meyers G.,Thiel H.-J.
Serine protease of pestiviruses: determination of cleavage sites.
J. Virol.
71
5415-5422
1997
207411
Harada T.,Tautz N.,Thiel H.-J.
E2-p7 region of the bovine viral diarrhea virus polyprotein: processing and functional studies.
J. Virol.
74
9498-9506
2000
207412
Lackner T.,Mueller A.,Pankraz A.,Becher P.,Thiel H.-J.,Gorbalenya A.E.,Tautz N.
Temporal modulation of an autoprotease is crucial for replication and pathogenicity of an RNA virus.
J. Virol.
78
10765-10775
2004
207413
Tews B.A.,Meyers G.
The pestivirus glycoprotein Erns is anchored in plane in the membrane via an amphipathic helix.
J. Biol. Chem.
282
32730-32741
2007
