Sequence of IF2G_HUMAN
EC Number:3.6.5.3
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
GTP + H2O = GDP + phosphate
Other sequences found for EC No. 3.6.5.3
General information:
Sequence
0 MAGGEAGVTL GQPHLSRQDL TTLDVTKLTP LSHEVISRQA TINIGTIGHV AHGKSTVVKA
60 ISGVHTVRFK NELERNITIK LGYANAKIYK LDDPSCPRPE CYRSCGSSTP DEFPTDIPGT
120 KGNFKLVRHV SFVDCPGHDI LMATMLNGAA VMDAALLLIA GNESCPQPQT SEHLAAIEIM
180 KLKHILILQN KIDLVKESQA KEQYEQILAF VQGTVAEGAP IIPISAQLKY NIEVVCEYIV
240 KKIPVPPRDF TSEPRLIVIR SFDVNKPGCE VDDLKGGVAG GSILKGVLKV GQEIEVRPGI
300 VSKDSEGKLM CKPIFSKIVS LFAEHNDLQY AAPGGLIGVG TKIDPTLCRA DRMVGQVLGA
360 VGALPEIFTE LEISYFLLRR LLGVRTEGDK KAAKVQKLSK NEVLMVNIGS LSTGGRVSAV
420 KADLGKIVLT NPVCTEVGEK IALSRRVEKH WRLIGWGQIR RGVTIKPTVD DD
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
175378
Gaspar N.J.,Kinzy T.G.,Scherer B.J.,Huembelin M.,Hershey J.W.B.,Merrick W.C.
Translation initiation factor eIF-2. Cloning and expression of the human cDNA encoding the gamma-subunit.
J. Biol. Chem.
269
3415-3422
1994
175379
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
175380
Goshima N.,Kawamura Y.,Fukumoto A.,Miura A.,Honma R.,Satoh R.,Wakamatsu A.,Yamamoto J.,Kimura K.,Nishikawa T.,Andoh T.,Iida Y.,Ishikawa K.,Ito E.,Kagawa N.,Kaminaga C.,Kanehori K.,Kawakami B.,Kenmochi K.,Kimura R.,Kobayashi M.,Kuroita T.,Kuwayama H.,Maruyama Y.,Matsuo K.,Minami K.,Mitsubori M.,Mori M.,Morishita R.,Murase A.,Nishikawa A.,Nishikawa S.,Okamoto T.,Sakagami N.,Sakamoto Y.,Sasaki Y.,Seki T.,Sono S.,Sugiyama A.,Sumiya T.,Takayama T.,Takayama Y.,Takeda H.,Togashi T.,Yahata K.,Yamada H.,Yanagisawa Y.,Endo Y.,Imamoto F.,Kisu Y.,Tanaka S.,Isogai T.,Imai J.,Watanabe S.,Nomura N.
Human protein factory for converting the transcriptome into an in vitro-expressed proteome.
Nat. Methods
5
1011-1017
2008
175383
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
175384
Gevaert K.,Goethals M.,Martens L.,Van Damme J.,Staes A.,Thomas G.R.,Vandekerckhove J.
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
Nat. Biotechnol.
21
566-569
2003
175386
Ehrmann I.E.,Ellis P.S.,Mazeyrat S.,Duthie S.,Brockdorff N.,Mattei M.-G.,Gavin M.A.,Affara N.A.,Brown G.M.,Simpson E.,Mitchell M.J.,Scott D.M.
Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution.
Hum. Mol. Genet.
7
1725-1737
1998
175387
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
175388
Borck G.,Shin B.S.,Stiller B.,Mimouni-Bloch A.,Thiele H.,Kim J.R.,Thakur M.,Skinner C.,Aschenbach L.,Smirin-Yosef P.,Har-Zahav A.,Nuernberg G.,Altmueller J.,Frommolt P.,Hofmann K.,Konen O.,Nuernberg P.,Munnich A.,Schwartz C.E.,Gothelf D.,Colleaux L.,Dever T.E.,Kubisch C.,Basel-Vanagaite L.
eIF2gamma mutation that disrupts eIF2 complex integrity links intellectual disability to impaired translation initiation.
Mol. Cell
48
641-646
2012
175389
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
175390
Eliseev B.,Yeramala L.,Leitner A.,Karuppasamy M.,Raimondeau E.,Huard K.,Alkalaeva E.,Aebersold R.,Schaffitzel C.
Structure of a human cap-dependent 48S translation pre-initiation complex.
Nucleic Acids Res.
46
2678-2689
2018
175391
Kenner L.R.,Anand A.A.,Nguyen H.C.,Myasnikov A.G.,Klose C.J.,McGeever L.A.,Tsai J.C.,Miller-Vedam L.E.,Walter P.,Frost A.
eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response.
Science
364
491-495
2019
175392
Kashiwagi K.,Yokoyama T.,Nishimoto M.,Takahashi M.,Sakamoto A.,Yonemochi M.,Shirouzu M.,Ito T.
Structural basis for eIF2B inhibition in integrated stress response.
Science
364
495-499
2019
175393
Moortgat S.,Desir J.,Benoit V.,Boulanger S.,Pendeville H.,Nassogne M.C.,Lederer D.,Maystadt I.
Two novel EIF2S3 mutations associated with syndromic intellectual disability with severe microcephaly, growth retardation, and epilepsy.
Am. J. Med. Genet. A
170
2927-2933
2016
175394
Skopkova M.,Hennig F.,Shin B.S.,Turner C.E.,Stanikova D.,Brennerova K.,Stanik J.,Fischer U.,Henden L.,Mueller U.,Steinberger D.,Leshinsky-Silver E.,Bottani A.,Kurdiova T.,Ukropec J.,Nyitrayova O.,Kolnikova M.,Klimes I.,Borck G.,Bahlo M.,Haas S.A.,Kim J.R.,Lotspeich-Cole L.E.,Gasperikova D.,Dever T.E.,Kalscheuer V.M.
EIF2S3 mutations associated with severe X-linked intellectual disability syndrome MEHMO.
Hum. Mutat.
38
409-425
2017
