Sequence of UBP7_HUMAN
EC Number:3.4.19.12
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Other sequences found for EC No. 3.4.19.12
General information:
Sequence
0 MNHQQQQQQQ KAGEQQLSEP EDMEMEAGDT DDPPRITQNP VINGNVALSD GHNTAEEDME
60 DDTSWRSEAT FQFTVERFSR LSESVLSPPC FVRNLPWKIM VMPRFYPDRP HQKSVGFFLQ
120 CNAESDSTSW SCHAQAVLKI INYRDDEKSF SRRISHLFFH KENDWGFSNF MAWSEVTDPE
180 KGFIDDDKVT FEVFVQADAP HGVAWDSKKH TGYVGLKNQG ATCYMNSLLQ TLFFTNQLRK
240 AVYMMPTEGD DSSKSVPLAL QRVFYELQHS DKPVGTKKLT KSFGWETLDS FMQHDVQELC
300 RVLLDNVENK MKGTCVEGTI PKLFRGKMVS YIQCKEVDYR SDRREDYYDI QLSIKGKKNI
360 FESFVDYVAV EQLDGDNKYD AGEHGLQEAE KGVKFLTLPP VLHLQLMRFM YDPQTDQNIK
420 INDRFEFPEQ LPLDEFLQKT DPKDPANYIL HAVLVHSGDN HGGHYVVYLN PKGDGKWCKF
480 DDDVVSRCTK EEAIEHNYGG HDDDLSVRHC TNAYMLVYIR ESKLSEVLQA VTDHDIPQQL
540 VERLQEEKRI EAQKRKERQE AHLYMQVQIV AEDQFCGHQG NDMYDEEKVK YTVFKVLKNS
600 SLAEFVQSLS QTMGFPQDQI RLWPMQARSN GTKRPAMLDN EADGNKTMIE LSDNENPWTI
660 FLETVDPELA ASGATLPKFD KDHDVMLFLK MYDPKTRSLN YCGHIYTPIS CKIRDLLPVM
720 CDRAGFIQDT SLILYEEVKP NLTERIQDYD VSLDKALDEL MDGDIIVFQK DDPENDNSEL
780 PTAKEYFRDL YHRVDVIFCD KTIPNDPGFV VTLSNRMNYF QVAKTVAQRL NTDPMLLQFF
840 KSQGYRDGPG NPLRHNYEGT LRDLLQFFKP RQPKKLYYQQ LKMKITDFEN RRSFKCIWLN
900 SQFREEEITL YPDKHGCVRD LLEECKKAVE LGEKASGKLR LLEIVSYKII GVHQEDELLE
960 CLSPATSRTF RIEEIPLDQV DIDKENEMLV TVAHFHKEVF GTFGIPFLLR IHQGEHFREV
1020 MKRIQSLLDI QEKEFEKFKF AIVMMGRHQY INEDEYEVNL KDFEPQPGNM SHPRPWLGLD
1080 HFNKAPKRSR YTYLEKAIKI HN
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
625437
Everett R.D.,Meredith M.,Orr A.,Cross A.,Kathoria M.,Parkinson J.
A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein.
EMBO J.
16
566-577
1997
625438
Everett R.D.,Meredith M.,Orr A.,Cross A.,Kathoria M.,Parkinson J.
EMBO J.
16
1519-1530
1997
625439
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
625440
Martin J.,Han C.,Gordon L.A.,Terry A.,Prabhakar S.,She X.,Xie G.,Hellsten U.,Chan Y.M.,Altherr M.,Couronne O.,Aerts A.,Bajorek E.,Black S.,Blumer H.,Branscomb E.,Brown N.C.,Bruno W.J.,Buckingham J.M.,Callen D.F.,Campbell C.S.,Campbell M.L.,Campbell E.W.,Caoile C.,Challacombe J.F.,Chasteen L.A.,Chertkov O.,Chi H.C.,Christensen M.,Clark L.M.,Cohn J.D.,Denys M.,Detter J.C.,Dickson M.,Dimitrijevic-Bussod M.,Escobar J.,Fawcett J.J.,Flowers D.,Fotopulos D.,Glavina T.,Gomez M.,Gonzales E.,Goodstein D.,Goodwin L.A.,Grady D.L.,Grigoriev I.,Groza M.,Hammon N.,Hawkins T.,Haydu L.,Hildebrand C.E.,Huang W.,Israni S.,Jett J.,Jewett P.B.,Kadner K.,Kimball H.,Kobayashi A.,Krawczyk M.-C.,Leyba T.,Longmire J.L.,Lopez F.,Lou Y.,Lowry S.,Ludeman T.,Manohar C.F.,Mark G.A.,McMurray K.L.,Meincke L.J.,Morgan J.,Moyzis R.K.,Mundt M.O.,Munk A.C.,Nandkeshwar R.D.,Pitluck S.,Pollard M.,Predki P.,Parson-Quintana B.,Ramirez L.,Rash S.,Retterer J.,Ricke D.O.,Robinson D.L.,Rodriguez A.,Salamov A.,Saunders E.H.,Scott D.,Shough T.,Stallings R.L.,Stalvey M.,Sutherland R.D.,Tapia R.,Tesmer J.G.,Thayer N.,Thompson L.S.,Tice H.,Torney D.C.,Tran-Gyamfi M.,Tsai M.,Ulanovsky L.E.,Ustaszewska A.,Vo N.,White P.S.,Williams A.L.,Wills P.L.,Wu J.-R.,Wu K.,Yang J.,DeJong P.,Bruce D.,Doggett N.A.,Deaven L.,Schmutz J.,Grimwood J.,Richardson P.,Rokhsar D.S.,Eichler E.E.,Gilna P.,Lucas S.M.,Myers R.M.,Rubin E.M.,Pennacchio L.A.
The sequence and analysis of duplication-rich human chromosome 16.
Nature
432
988-994
2004
625442
Hong S.,Kim S.J.,Ka S.,Choi I.,Kang S.
USP7, a ubiquitin-specific protease, interacts with ataxin-1, the SCA1 gene product.
Mol. Cell. Neurosci.
20
298-306
2002
625443
Li M.,Chen D.,Shiloh A.,Luo J.,Nikolaev A.Y.,Qin J.,Gu W.
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization.
Nature
416
648-653
2002
625444
Holowaty M.N.,Sheng Y.,Nguyen T.,Arrowsmith C.,Frappier L.
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
J. Biol. Chem.
278
47753-47761
2003
625445
Li M.,Brooks C.L.,Kon N.,Gu W.
A dynamic role of HAUSP in the p53-Mdm2 pathway.
Mol. Cell
13
879-886
2004
625446
Boutell C.,Canning M.,Orr A.,Everett R.D.
Reciprocal activities between herpes simplex virus type 1 regulatory protein ICP0, a ubiquitin E3 ligase, and ubiquitin-specific protease USP7.
J. Virol.
79
12342-12354
2005
625447
Tang J.,Qu L.K.,Zhang J.,Wang W.,Michaelson J.S.,Degenhardt Y.Y.,El-Deiry W.S.,Yang X.
Critical role for Daxx in regulating Mdm2.
Nat. Cell Biol.
8
855-862
2006
625448
van der Horst A.,de Vries-Smits A.M.,Brenkman A.B.,van Triest M.H.,van den Broek N.,Colland F.,Maurice M.M.,Burgering B.M.
FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP.
Nat. Cell Biol.
8
1064-1073
2006
625449
Fernandez-Montalvan A.,Bouwmeester T.,Joberty G.,Mader R.,Mahnke M.,Pierrat B.,Schlaeppi J.M.,Worpenberg S.,Gerhartz B.
Biochemical characterization of USP7 reveals post-translational modification sites and structural requirements for substrate processing and subcellular localization.
FEBS J.
274
4256-4270
2007
625450
Song M.S.,Song S.J.,Kim S.Y.,Oh H.J.,Lim D.S.
The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex.
EMBO J.
27
1863-1874
2008
625451
Zweitzig D.R.,Shcherbik N.,Haines D.S.
AAA ATPase p97 and adaptor UBXD1 suppress MDM2 ubiquitination and degradation and promote constitutive p53 turnover.
Mol. Biol. Cell
19
5029-5029
2008
625452
Song M.S.,Salmena L.,Carracedo A.,Egia A.,Lo-Coco F.,Teruya-Feldstein J.,Pandolfi P.P.
The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network.
Nature
455
813-817
2008
625453
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
625454
Antrobus R.,Boutell C.
Identification of a novel higher molecular weight isoform of USP7/HAUSP that interacts with the Herpes simplex virus type-1 immediate early protein ICP0.
Virus Res.
137
64-71
2008
625455
Gauci S.,Helbig A.O.,Slijper M.,Krijgsveld J.,Heck A.J.,Mohammed S.
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Anal. Chem.
81
4493-4501
2009
625456
Choudhary C.,Kumar C.,Gnad F.,Nielsen M.L.,Rehman M.,Walther T.C.,Olsen J.V.,Mann M.
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Science
325
834-840
2009
625457
Tang J.,Qu L.,Pang M.,Yang X.
Daxx is reciprocally regulated by Mdm2 and Hausp.
Biochem. Biophys. Res. Commun.
393
542-545
2010
625458
Maertens G.N.,El Messaoudi-Aubert S.,Elderkin S.,Hiom K.,Peters G.
Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor.
EMBO J.
29
2553-2565
2010
625459
Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Sci. Signal.
3
0-0
2010
625460
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
625461
Epping M.T.,Meijer L.A.,Krijgsman O.,Bos J.L.,Pandolfi P.P.,Bernards R.
TSPYL5 suppresses p53 levels and function by physical interaction with USP7.
Nat. Cell Biol.
13
102-108
2011
625462
Huang Z.,Wu Q.,Guryanova O.A.,Cheng L.,Shou W.,Rich J.N.,Bao S.
Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells.
Nat. Cell Biol.
13
142-152
2011
625463
Felle M.,Joppien S.,Nemeth A.,Diermeier S.,Thalhammer V.,Dobner T.,Kremmer E.,Kappler R.,Langst G.
The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1.
Nucleic Acids Res.
39
8355-8365
2011
625464
Rigbolt K.T.,Prokhorova T.A.,Akimov V.,Henningsen J.,Johansen P.T.,Kratchmarova I.,Kassem M.,Mann M.,Olsen J.V.,Blagoev B.
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
Sci. Signal.
4
0-0
2011
625465
Salsman J.,Jagannathan M.,Paladino P.,Chan P.K.,Dellaire G.,Raught B.,Frappier L.
Proteomic profiling of the human cytomegalovirus UL35 gene products reveals a role for UL35 in the DNA repair response.
J. Virol.
86
806-820
2012
625466
Ma H.,Chen H.,Guo X.,Wang Z.,Sowa M.E.,Zheng L.,Hu S.,Zeng P.,Guo R.,Diao J.,Lan F.,Harper J.W.,Shi Y.G.,Xu Y.,Shi Y.
M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability.
Proc. Natl. Acad. Sci. U.S.A.
109
4828-4833
2012
625467
Iphofer A.,Kummer A.,Nimtz M.,Ritter A.,Arnold T.,Frank R.,van den Heuvel J.,Kessler B.M.,Jansch L.,Franke R.
Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes.
ChemBioChem
13
1416-1420
2012
625468
Cano F.,Bye H.,Duncan L.M.,Buchet-Poyau K.,Billaud M.,Wills M.R.,Lehner P.J.
The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation.
EMBO J.
31
3596-3606
2012
625469
Schwertman P.,Lagarou A.,Dekkers D.H.,Raams A.,van der Hoek A.C.,Laffeber C.,Hoeijmakers J.H.,Demmers J.A.,Fousteri M.,Vermeulen W.,Marteijn J.A.
UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair.
Nat. Genet.
44
598-602
2012
625470
Zhang X.,Horibata K.,Saijo M.,Ishigami C.,Ukai A.,Kanno S.I.,Tahara H.,Neilan E.G.,Honma M.,Nohmi T.,Yasui A.,Tanaka K.
Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair.
Nat. Genet.
44
593-597
2012
625471
van Loosdregt J.,Fleskens V.,Fu J.,Brenkman A.B.,Bekker C.P.,Pals C.E.,Meerding J.,Berkers C.R.,Barbi J.,Grone A.,Sijts A.J.,Maurice M.M.,Kalkhoven E.,Prakken B.J.,Ovaa H.,Pan F.,Zaiss D.M.,Coffer P.J.
Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity.
Immunity
39
259-271
2013
625472
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
625473
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
625474
Ma P.,Yang X.,Kong Q.,Li C.,Yang S.,Li Y.,Mao B.
The ubiquitin ligase RNF220 enhances canonical Wnt signaling through USP7-mediated deubiquitination of beta-catenin.
Mol. Cell. Biol.
34
4355-4366
2014
625475
Zhang J.,Cao M.,Dong J.,Li C.,Xu W.,Zhan Y.,Wang X.,Yu M.,Ge C.,Ge Z.,Yang X.
ABRO1 suppresses tumourigenesis and regulates the DNA damage response by stabilizing p53.
Nat. Commun.
5
5059-5059
2014
625476
Impens F.,Radoshevich L.,Cossart P.,Ribet D.
Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
Proc. Natl. Acad. Sci. U.S.A.
111
12432-12437
2014
625477
Cui H.,Guo M.,Xu D.,Ding Z.C.,Zhou G.,Ding H.F.,Zhang J.,Tang Y.,Yan C.
The stress-responsive gene ATF3 regulates the histone acetyltransferase Tip60.
Nat. Commun.
6
6752-6752
2015
625478
Nicolai S.,Filippi S.,Caputo M.,Cipak L.,Gregan J.,Ammerer G.,Frontini M.,Willems D.,Prantera G.,Balajee A.S.,Proietti-De-Santis L.
Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.
PLoS ONE
10
0-0
2015
625479
Ding X.,Jiang W.,Zhou P.,Liu L.,Wan X.,Yuan X.,Wang X.,Chen M.,Chen J.,Yang J.,Kong C.,Li B.,Peng C.,Wong C.C.,Hou F.,Zhang Y.
Mixed lineage leukemia 5 (MLL5) protein stability is cooperatively regulated by O-GlcNac transferase (OGT) and ubiquitin specific protease 7 (USP7).
PLoS ONE
10
0-0
2015
625480
Hirano A.,Nakagawa T.,Yoshitane H.,Oyama M.,Kozuka-Hata H.,Lanjakornsiripan D.,Fukada Y.
USP7 and TDP-43: pleiotropic regulation of cryptochrome protein stability paces the oscillation of the mammalian circadian clock.
PLoS ONE
11
0-0
2016
625481
Jiang L.,Xiong J.,Zhan J.,Yuan F.,Tang M.,Zhang C.,Cao Z.,Chen Y.,Lu X.,Li Y.,Wang H.,Wang L.,Wang J.,Zhu W.G.,Wang H.
Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis.
J. Biol. Chem.
292
13296-13311
2017
625482
Hendriks I.A.,Lyon D.,Young C.,Jensen L.J.,Vertegaal A.C.,Nielsen M.L.
Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
Nat. Struct. Mol. Biol.
24
325-336
2017
625483
Hu M.,Li P.,Li M.,Li W.,Yao T.,Wu J.-W.,Gu W.,Cohen R.E.,Shi Y.
Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde.
Cell
111
1041-1054
2002
625484
Saridakis V.,Sheng Y.,Sarkari F.,Holowaty M.N.,Shire K.,Nguyen T.,Zhang R.G.,Liao J.,Lee W.,Edwards A.M.,Arrowsmith C.H.,Frappier L.
Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization.
Mol. Cell
18
25-36
2005
625485
Hu M.,Gu L.,Li M.,Jeffrey P.D.,Gu W.,Shi Y.
Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway.
PLoS Biol.
4
228-239
2006
625486
Sheng Y.,Saridakis V.,Sarkari F.,Duan S.,Wu T.,Arrowsmith C.H.,Frappier L.
Molecular recognition of p53 and MDM2 by USP7/HAUSP.
Nat. Struct. Mol. Biol.
13
285-291
2006
625487
Zhao Y.,Majid M.C.,Soll J.M.,Brickner J.R.,Dango S.,Mosammaparast N.
Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase.
EMBO J.
34
1687-1703
2015
