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Sequence of CNDP1_HUMAN

EC Number:3.4.13.20

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
beta-Ala-His dipeptidase
Q96KN2
Homo sapiens
507
56692
Reaction
preferential hydrolysis of the beta-Ala-/-His dipeptide (carnosine), and also anserine, Xaa-/-His dipeptides and other dipeptides including homocarnosine
Other sequences found for EC No. 3.4.13.20

General information:

Sequence
show sequence in fasta format
  0 MDPKLGRMAA SLLAVLLLLL ERGMFSSPSP PPALLEKVFQ YIDLHQDEFV QTLKEWVAIE
 60 SDSVQPVPRF RQELFRMMAV AADTLQRLGA RVASVDMGPQ QLPDGQSLPI PPVILAELGS
120 DPTKGTVCFY GHLDVQPADR GDGWLTDPYV LTEVDGKLYG RGATDNKGPV LAWINAVSAF
180 RALEQDLPVN IKFIIEGMEE AGSVALEELV EKEKDRFFSG VDYIVISDNL WISQRKPAIT
240 YGTRGNSYFM VEVKCRDQDF HSGTFGGILH EPMADLVALL GSLVDSSGHI LVPGIYDEVV
300 PLTEEEINTY KAIHLDLEEY RNSSRVEKFL FDTKEEILMH LWRYPSLSIH GIEGAFDEPG
360 TKTVIPGRVI GKFSIRLVPH MNVSAVEKQV TRHLEDVFSK RNSSNKMVVS MTLGLHPWIA
420 NIDDTQYLAA KRAIRTVFGT EPDMIRDGST IPIAKMFQEI VHKSVVLIPL GAVDDGEHSQ
480 NEKINRWNYI EGTKLFAAFF LEMAQLH
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1170540
Janssen B.,Hohenadel D.,Brinkkoetter P.,Peters V.,Rind N.,Fischer C.,Rychlik I.,Cerna M.,Romzova M.,de Heer E.,Baelde H.,Bakker S.J.,Zirie M.,Rondeau E.,Mathieson P.,Saleem M.A.,Meyer J.,Koppel H.,Sauerhoefer S.,Bartram C.R.,Nawroth P.,Hammes H.P.,Yard B.A.,Zschocke J.,van der Woude F.J.
Carnosine as a protective factor in diabetic nephropathy: association with a leucine repeat of the carnosinase gene CNDP1.
Diabetes
54
2320-2327
2005
1170541
Clark H.F.,Gurney A.L.,Abaya E.,Baker K.,Baldwin D.T.,Brush J.,Chen J.,Chow B.,Chui C.,Crowley C.,Currell B.,Deuel B.,Dowd P.,Eaton D.,Foster J.S.,Grimaldi C.,Gu Q.,Hass P.E.,Heldens S.,Huang A.,Kim H.S.,Klimowski L.,Jin Y.,Johnson S.,Lee J.,Lewis L.,Liao D.,Mark M.R.,Robbie E.,Sanchez C.,Schoenfeld J.,Seshagiri S.,Simmons L.,Singh J.,Smith V.,Stinson J.,Vagts A.,Vandlen R.L.,Watanabe C.,Wieand D.,Woods K.,Xie M.-H.,Yansura D.G.,Yi S.,Yu G.,Yuan J.,Zhang M.,Zhang Z.,Goddard A.D.,Wood W.I.,Godowski P.J.,Gray A.M.
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
Genome Res.
13
2265-2270
2003
1170542
Nusbaum C.,Zody M.C.,Borowsky M.L.,Kamal M.,Kodira C.D.,Taylor T.D.,Whittaker C.A.,Chang J.L.,Cuomo C.A.,Dewar K.,FitzGerald M.G.,Yang X.,Abouelleil A.,Allen N.R.,Anderson S.,Bloom T.,Bugalter B.,Butler J.,Cook A.,DeCaprio D.,Engels R.,Garber M.,Gnirke A.,Hafez N.,Hall J.L.,Norman C.H.,Itoh T.,Jaffe D.B.,Kuroki Y.,Lehoczky J.,Lui A.,Macdonald P.,Mauceli E.,Mikkelsen T.S.,Naylor J.W.,Nicol R.,Nguyen C.,Noguchi H.,O'Leary S.B.,Piqani B.,Smith C.L.,Talamas J.A.,Topham K.,Totoki Y.,Toyoda A.,Wain H.M.,Young S.K.,Zeng Q.,Zimmer A.R.,Fujiyama A.,Hattori M.,Birren B.W.,Sakaki Y.,Lander E.S.
DNA sequence and analysis of human chromosome 18.
Nature
437
551-555
2005
1170543
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
1170544
Lenney J.F.,George R.P.,Weiss A.M.,Kucera C.M.,Chan P.W.,Rinzler G.S.
Human serum carnosinase: characterization, distinction from cellular carnosinase, and activation by cadmium.
Clin. Chim. Acta
123
221-231
1982
1170545
Lenney J.F.,Peppers S.C.,Kucera C.M.,Sjaastad O.
Homocarnosinosis: lack of serum carnosinase is the defect probably responsible for elevated brain and CSF homocarnosine.
Clin. Chim. Acta
132
157-165
1983
1170546
Teufel M.,Saudek V.,Ledig J.P.,Bernhardt A.,Boularand S.,Carreau A.,Cairns N.J.,Carter C.,Cowley D.J.,Duverger D.,Ganzhorn A.J.,Guenet C.,Heintzelmann B.,Laucher V.,Sauvage C.,Smirnova T.
Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase.
J. Biol. Chem.
278
6521-6531
2003
1170547
Liu T.,Qian W.-J.,Gritsenko M.A.,Camp D.G. II,Monroe M.E.,Moore R.J.,Smith R.D.
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
J. Proteome Res.
4
2070-2080
2005
1170548
Veiga-da-Cunha M.,Chevalier N.,Stroobant V.,Vertommen D.,Van Schaftingen E.
Metabolite proofreading in carnosine and homocarnosine synthesis: molecular identification of PM20D2 as beta-alanyl-lysine dipeptidase.
J. Biol. Chem.
289
19726-19736
2014