Sequence of POL_HV1MP
EC Number:3.1.26.13
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
retroviral ribonuclease H
Q9QBZ5
Human immunodeficiency virus type 1 group M subtype F2 (isolate MP255)
1430
161574
Reaction
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
Other sequences found for EC No. 3.1.26.13
General information:
Sequence
0 MGARASVLSG GKLDAWEKIR LKPGGKKRYR LKHLVWASRE LERFALNPSL LETTEGCKKI
60 IGQLQSSLQT GSEELKSLYN AVVVLYYVHQ RIDVRDTKEA LDKLQEEQDK SQQKEQQKAA
120 DKEVSQNYPI VQNIQGQMVH QALSPRTLNA WVKVIEEKAF SPEVIPMFSA LSEGATPQDL
180 NTMLNTVGGH QAAMQMLKDT INEEAAEWDR LHPVHAGPIP PGQMREPRGS DIAGTTSTLQ
240 EQITWMTGNP PVPVGEIYKR WIILGLNKIV RMYSPVSILD IKQGPKEPFR DYVDRFFKTL
300 RAEQATQEVK NWMTETLLVQ NSNPDCKTIL KALGPGATLE EMMTACQGVG GPGHKARILA
360 EAMSKATSTA IMMQKSNFKG QKRIVKCFNC GKEGHIARNC RAPRKKGCWK CGKEGHQMKD
420 CTERQANFFR ENLAFQQGEA RKFSSEQTRA NSPASRELRV RRGDNPLPEA GAERRGTGSS
480 LSFPQITLWQ RPLVAIRVGG QLREALLDTG ADDTVLEDIN LPGKWKPKMI GGIGGFIKVR
540 QYDQIPIEIC GQKAIGTVLV GPTPVNIIGR NLLTQLGCTL NFPISPIETV PVKLKPGMDG
600 PRVKQWPLTE EKIKALTEIC TEMEKEGKIS KIGPENPYNT PVFAIKKKDS TKWRKLVDFR
660 ELNKRTQDFW EVQLGIPHPA GLKKKKSVTV LDVGDAYFSV PLDKEFRKYT AFTIPSINNE
720 TPGIRYQYNV LPQGWKGSPA IFQCSMTKIL EPFRAKNPEI VIYQYMDDLY VGSDLEIGQH
780 RTKIEELREH LLKWGFTTPD KKHQKEPPFL WMGYELHPDK WTVQPIQLPE KSSWTVNDIQ
840 KLVGKLNWAS QIYPGIRIKH LCRLLRGAKA LTDVVPLTAE AELELAENRE IIKEPVHGVY
900 YDPSKDLIAE IQKQGHDQWT YQIYQEPYKN LKTGKYAKRK SAHTNDVKQL TEVVQKIATE
960 SIVIWGKIPK FRLPIQKETW EIWWTEYWQA TWIPEWEFVN TPPLVKLWYQ LETEPIAGAE
1020 TFYVDGAANR ETKLGKAGYV TDRGRQKVVP LTETTNQKTE LQAIHLALQD SGSEVNIVTD
1080 SQYALGIIQA QPDKSESELV NQIIEQLIQK EKVYLSWVPA HKGIGGNEQV DKLVSSGIRK
1140 VLFLDGIDKA QEEHEKYHNN WRAMASDFNL PPVVAKEIVA NCDKCQLKGE AMHGQVDCSP
1200 GIWQLDCTHL EGKIILVAVH VASGYIEAEV IPAETGQETA YFILKLAGRW PVKIIHTDNG
1260 SNFTSTVVKA ACWWAGIQQE FGVPYNPQSQ GVVESMNKEL KKIIGQIRDQ AEHLKTAVQM
1320 AVFIHNFKRK GGIGGYSAGE RIIDIIATDI QTKELQKQIT KIQNFRVYFR DSRDPVWKGP
1380 AKLLWKGEGA VVIQDNNEIK VVPRRKAKII RDYGKQMAGD DCVAGRQDED
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
842625
Triques K.,Bourgeois A.,Vidale N.,Mpoudi-Ngole E.,Mulanga-Kabeya C.,Nzilambi N.,Torimiro N.,Saman E.,Delaporte E.,Peeters M.
Near-full-length genome sequencing of divergent African HIV type 1 subtype F viruses leads to the identification of a new HIV type 1 subtype designated K.
AIDS Res. Hum. Retroviruses
16
139-151
2000
