Sequence of CHD4_HUMAN
EC Number:3.6.4.12
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Other sequences found for EC No. 3.6.4.12
General information:
Sequence
0 MASGLGSPSP CSAGSEEEDM DALLNNSLPP PHPENEEDPE EDLSETETPK LKKKKKPKKP
60 RDPKIPKSKR QKKERMLLCR QLGDSSGEGP EFVEEEEEVA LRSDSEGSDY TPGKKKKKKL
120 GPKKEKKSKS KRKEEEEEED DDDDSKEPKS SAQLLEDWGM EDIDHVFSEE DYRTLTNYKA
180 FSQFVRPLIA AKNPKIAVSK MMMVLGAKWR EFSTNNPFKG SSGASVAAAA AAAVAVVESM
240 VTATEVAPPP PPVEVPIRKA KTKEGKGPNA RRKPKGSPRV PDAKKPKPKK VAPLKIKLGG
300 FGSKRKRSSS EDDDLDVESD FDDASINSYS VSDGSTSRSS RSRKKLRTTK KKKKGEEEVT
360 AVDGYETDHQ DYCEVCQQGG EIILCDTCPR AYHMVCLDPD MEKAPEGKWS CPHCEKEGIQ
420 WEAKEDNSEG EEILEEVGGD LEEEDDHHME FCRVCKDGGE LLCCDTCPSS YHIHCLNPPL
480 PEIPNGEWLC PRCTCPALKG KVQKILIWKW GQPPSPTPVP RPPDADPNTP SPKPLEGRPE
540 RQFFVKWQGM SYWHCSWVSE LQLELHCQVM FRNYQRKNDM DEPPSGDFGG DEEKSRKRKN
600 KDPKFAEMEE RFYRYGIKPE WMMIHRILNH SVDKKGHVHY LIKWRDLPYD QASWESEDVE
660 IQDYDLFKQS YWNHRELMRG EEGRPGKKLK KVKLRKLERP PETPTVDPTV KYERQPEYLD
720 ATGGTLHPYQ MEGLNWLRFS WAQGTDTILA DEMGLGKTVQ TAVFLYSLYK EGHSKGPFLV
780 SAPLSTIINW EREFEMWAPD MYVVTYVGDK DSRAIIRENE FSFEDNAIRG GKKASRMKKE
840 ASVKFHVLLT SYELITIDMA ILGSIDWACL IVDEAHRLKN NQSKFFRVLN GYSLQHKLLL
900 TGTPLQNNLE ELFHLLNFLT PERFHNLEGF LEEFADIAKE DQIKKLHDML GPHMLRRLKA
960 DVFKNMPSKT ELIVRVELSP MQKKYYKYIL TRNFEALNAR GGGNQVSLLN VVMDLKKCCN
1020 HPYLFPVAAM EAPKMPNGMY DGSALIRASG KLLLLQKMLK NLKEGGHRVL IFSQMTKMLD
1080 LLEDFLEHEG YKYERIDGGI TGNMRQEAID RFNAPGAQQF CFLLSTRAGG LGINLATADT
1140 VIIYDSDWNP HNDIQAFSRA HRIGQNKKVM IYRFVTRASV EERITQVAKK KMMLTHLVVR
1200 PGLGSKTGSM SKQELDDILK FGTEELFKDE ATDGGGDNKE GEDSSVIHYD DKAIERLLDR
1260 NQDETEDTEL QGMNEYLSSF KVAQYVVREE EMGEEEEVER EIIKQEESVD PDYWEKLLRH
1320 HYEQQQEDLA RNLGKGKRIR KQVNYNDGSQ EDRDWQDDQS DNQSDYSVAS EEGDEDFDER
1380 SEAPRRPSRK GLRNDKDKPL PPLLARVGGN IEVLGFNARQ RKAFLNAIMR YGMPPQDAFT
1440 TQWLVRDLRG KSEKEFKAYV SLFMRHLCEP GADGAETFAD GVPREGLSRQ HVLTRIGVMS
1500 LIRKKVQEFE HVNGRWSMPE LAEVEENKKM SQPGSPSPKT PTPSTPGDTQ PNTPAPVPPA
1560 EDGIKIEENS LKEEESIEGE KEVKSTAPET AIECTQAPAP ASEDEKVVVE PPEGEEKVEK
1620 AEVKERTEEP METEPKGAAD VEKVEEKSAI DLTPIVVEDK EEKKEEEEKK EVMLQNGETP
1680 KDLNDEKQKK NIKQRFMFNI ADGGFTELHS LWQNEERAAT VTKKTYEIWH RRHDYWLLAG
1740 IINHGYARWQ DIQNDPRYAI LNEPFKGEMN RGNFLEIKNK FLARRFKLLE QALVIEEQLR
1800 RAAYLNMSED PSHPSMALNT RFAEVECLAE SHQHLSKESM AGNKPANAVL HKVLKQLEEL
1860 LSDMKADVTR LPATIARIPP VAVRLQMSER NILSRLANRA PEPTPQQVAQ QQ
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
526307
Seelig H.P.,Moosbrugger I.,Ehrfeld H.,Fink T.,Renz M.,Genth E.
The major dermatomyositis specific Mi-2 autoantigen is a presumed helicase involved in transcriptional activation.
Arthritis Rheum.
38
1389-1399
1995
526308
Scherer S.E.,Muzny D.M.,Buhay C.J.,Chen R.,Cree A.,Ding Y.,Dugan-Rocha S.,Gill R.,Gunaratne P.,Harris R.A.,Hawes A.C.,Hernandez J.,Hodgson A.V.,Hume J.,Jackson A.,Khan Z.M.,Kovar-Smith C.,Lewis L.R.,Lozado R.J.,Metzker M.L.,Milosavljevic A.,Miner G.R.,Montgomery K.T.,Morgan M.B.,Nazareth L.V.,Scott G.,Sodergren E.,Song X.-Z.,Steffen D.,Lovering R.C.,Wheeler D.A.,Worley K.C.,Yuan Y.,Zhang Z.,Adams C.Q.,Ansari-Lari M.A.,Ayele M.,Brown M.J.,Chen G.,Chen Z.,Clerc-Blankenburg K.P.,Davis C.,Delgado O.,Dinh H.H.,Draper H.,Gonzalez-Garay M.L.,Havlak P.,Jackson L.R.,Jacob L.S.,Kelly S.H.,Li L.,Li Z.,Liu J.,Liu W.,Lu J.,Maheshwari M.,Nguyen B.-V.,Okwuonu G.O.,Pasternak S.,Perez L.M.,Plopper F.J.H.,Santibanez J.,Shen H.,Tabor P.E.,Verduzco D.,Waldron L.,Wang Q.,Williams G.A.,Zhang J.,Zhou J.,Allen C.C.,Amin A.G.,Anyalebechi V.,Bailey M.,Barbaria J.A.,Bimage K.E.,Bryant N.P.,Burch P.E.,Burkett C.E.,Burrell K.L.,Calderon E.,Cardenas V.,Carter K.,Casias K.,Cavazos I.,Cavazos S.R.,Ceasar H.,Chacko J.,Chan S.N.,Chavez D.,Christopoulos C.,Chu J.,Cockrell R.,Cox C.D.,Dang M.,Dathorne S.R.,David R.,Davis C.M.,Davy-Carroll L.,Deshazo D.R.,Donlin J.E.,D'Souza L.,Eaves K.A.,Egan A.,Emery-Cohen A.J.,Escotto M.,Flagg N.,Forbes L.D.,Gabisi A.M.,Garza M.,Hamilton C.,Henderson N.,Hernandez O.,Hines S.,Hogues M.E.,Huang M.,Idlebird D.G.,Johnson R.,Jolivet A.,Jones S.,Kagan R.,King L.M.,Leal B.,Lebow H.,Lee S.,LeVan J.M.,Lewis L.C.,London P.,Lorensuhewa L.M.,Loulseged H.,Lovett D.A.,Lucier A.,Lucier R.L.,Ma J.,Madu R.C.,Mapua P.,Martindale A.D.,Martinez E.,Massey E.,Mawhiney S.,Meador M.G.,Mendez S.,Mercado C.,Mercado I.C.,Merritt C.E.,Miner Z.L.,Minja E.,Mitchell T.,Mohabbat F.,Mohabbat K.,Montgomery B.,Moore N.,Morris S.,Munidasa M.,Ngo R.N.,Nguyen N.B.,Nickerson E.,Nwaokelemeh O.O.,Nwokenkwo S.,Obregon M.,Oguh M.,Oragunye N.,Oviedo R.J.,Parish B.J.,Parker D.N.,Parrish J.,Parks K.L.,Paul H.A.,Payton B.A.,Perez A.,Perrin W.,Pickens A.,Primus E.L.,Pu L.-L.,Puazo M.,Quiles M.M.,Quiroz J.B.,Rabata D.,Reeves K.,Ruiz S.J.,Shao H.,Sisson I.,Sonaike T.,Sorelle R.P.,Sutton A.E.,Svatek A.F.,Svetz L.A.,Tamerisa K.S.,Taylor T.R.,Teague B.,Thomas N.,Thorn R.D.,Trejos Z.Y.,Trevino B.K.,Ukegbu O.N.,Urban J.B.,Vasquez L.I.,Vera V.A.,Villasana D.M.,Wang L.,Ward-Moore S.,Warren J.T.,Wei X.,White F.,Williamson A.L.,Wleczyk R.,Wooden H.S.,Wooden S.H.,Yen J.,Yoon L.,Yoon V.,Zorrilla S.E.,Nelson D.,Kucherlapati R.,Weinstock G.,Gibbs R.A.
The finished DNA sequence of human chromosome 12.
Nature
440
346-351
2006
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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
526310
Tong J.K.,Hassig C.A.,Schnitzler G.R.,Kingston R.E.,Schreiber S.L.
Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex.
Nature
395
917-921
1998
526311
Schmidt D.R.,Schreiber S.L.
Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4.
Biochemistry
38
14711-14717
1999
526312
Kim J.,Sif S.,Jones B.,Jackson A.,Koipally J.,Heller E.,Winandy S.,Viel A.,Sawyer A.,Ikeda T.,Kingston R.,Georgopoulos K.
Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes.
Immunity
10
345-355
1999
526313
Hakimi M.-A.,Bochar D.A.,Schmiesing J.A.,Dong Y.,Barak O.G.,Speicher D.W.,Yokomori K.,Shiekhattar R.
A chromatin remodelling complex that loads cohesin onto human chromosomes.
Nature
418
994-998
2002
526314
Shimono Y.,Murakami H.,Kawai K.,Wade P.A.,Shimokata K.,Takahashi M.
Mi-2 beta associates with BRG1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities.
J. Biol. Chem.
278
51638-51645
2003
526315
Fujita N.,Jaye D.L.,Geigerman C.,Akyildiz A.,Mooney M.R.,Boss J.M.,Wade P.A.
MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation.
Cell
119
75-86
2004
526316
Olsen J.V.,Blagoev B.,Gnad F.,Macek B.,Kumar C.,Mortensen P.,Mann M.
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Cell
127
635-648
2006
526317
Sillibourne J.E.,Delaval B.,Redick S.,Sinha M.,Doxsey S.J.
Chromatin remodeling proteins interact with pericentrin to regulate centrosome integrity.
Mol. Biol. Cell
18
3667-3680
2007
526318
Matsuoka S.,Ballif B.A.,Smogorzewska A.,McDonald E.R. III,Hurov K.E.,Luo J.,Bakalarski C.E.,Zhao Z.,Solimini N.,Lerenthal Y.,Shiloh Y.,Gygi S.P.,Elledge S.J.
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Science
316
1160-1166
2007
526319
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
526320
Gauci S.,Helbig A.O.,Slijper M.,Krijgsveld J.,Heck A.J.,Mohammed S.
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Anal. Chem.
81
4493-4501
2009
526321
Li R.,Zhang H.,Yu W.,Chen Y.,Gui B.,Liang J.,Wang Y.,Sun L.,Yang X.,Zhang Y.,Shi L.,Li Y.,Shang Y.
ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis.
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28
2763-2776
2009
526322
Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Sci. Signal.
2
0-0
2009
526323
Choudhary C.,Kumar C.,Gnad F.,Nielsen M.L.,Rehman M.,Walther T.C.,Olsen J.V.,Mann M.
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Science
325
834-840
2009
526324
Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Sci. Signal.
3
0-0
2010
526325
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
526326
Rahman S.,Sowa M.E.,Ottinger M.,Smith J.A.,Shi Y.,Harper J.W.,Howley P.M.
The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.
Mol. Cell. Biol.
31
2641-2652
2011
526327
Rigbolt K.T.,Prokhorova T.A.,Akimov V.,Henningsen J.,Johansen P.T.,Kratchmarova I.,Kassem M.,Mann M.,Olsen J.V.,Blagoev B.
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
Sci. Signal.
4
0-0
2011
526328
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
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J. Proteome Res.
12
260-271
2013
526329
Yuce O.,West S.C.
Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response.
Mol. Cell. Biol.
33
406-417
2013
526330
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
526331
Hendriks I.A.,D'Souza R.C.,Yang B.,Verlaan-de Vries M.,Mann M.,Vertegaal A.C.
Uncovering global SUMOylation signaling networks in a site-specific manner.
Nat. Struct. Mol. Biol.
21
927-936
2014
526332
Impens F.,Radoshevich L.,Cossart P.,Ribet D.
Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
Proc. Natl. Acad. Sci. U.S.A.
111
12432-12437
2014
526333
Hendriks I.A.,Treffers L.W.,Verlaan-de Vries M.,Olsen J.V.,Vertegaal A.C.
SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
Cell Rep.
10
1778-1791
2015
526334
Xiao Z.,Chang J.G.,Hendriks I.A.,Sigurdsson J.O.,Olsen J.V.,Vertegaal A.C.
System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
Mol. Cell. Proteomics
14
1419-1434
2015
526335
Weiss K.,Terhal P.A.,Cohen L.,Bruccoleri M.,Irving M.,Martinez A.F.,Rosenfeld J.A.,Machol K.,Yang Y.,Liu P.,Walkiewicz M.,Beuten J.,Gomez-Ospina N.,Haude K.,Fong C.T.,Enns G.M.,Bernstein J.A.,Fan J.,Gotway G.,Ghorbani M.,van Gassen K.,Monroe G.R.,van Haaften G.,Basel-Vanagaite L.,Yang X.J.,Campeau P.M.,Muenke M.
De novo mutations in CHD4, an ATP-dependent chromatin remodeler gene, cause an intellectual disability syndrome with distinctive dysmorphisms.
Am. J. Hum. Genet.
99
934-941
2016
526336
Sifrim A.,Hitz M.P.,Wilsdon A.,Breckpot J.,Turki S.H.,Thienpont B.,McRae J.,Fitzgerald T.W.,Singh T.,Swaminathan G.J.,Prigmore E.,Rajan D.,Abdul-Khaliq H.,Banka S.,Bauer U.M.,Bentham J.,Berger F.,Bhattacharya S.,Bu'Lock F.,Canham N.,Colgiu I.G.,Cosgrove C.,Cox H.,Daehnert I.,Daly A.,Danesh J.,Fryer A.,Gewillig M.,Hobson E.,Hoff K.,Homfray T.,Kahlert A.K.,Ketley A.,Kramer H.H.,Lachlan K.,Lampe A.K.,Louw J.J.,Manickara A.K.,Manase D.,McCarthy K.P.,Metcalfe K.,Moore C.,Newbury-Ecob R.,Omer S.O.,Ouwehand W.H.,Park S.M.,Parker M.J.,Pickardt T.,Pollard M.O.,Robert L.,Roberts D.J.,Sambrook J.,Setchfield K.,Stiller B.,Thornborough C.,Toka O.,Watkins H.,Williams D.,Wright M.,Mital S.,Daubeney P.E.,Keavney B.,Goodship J.,Abu-Sulaiman R.M.,Klaassen S.,Wright C.F.,Firth H.V.,Barrett J.C.,Devriendt K.,FitzPatrick D.R.,Brook J.D.,Hurles M.E.
Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing.
Nat. Genet.
48
1060-1065
2016
526337
Hendriks I.A.,Lyon D.,Young C.,Jensen L.J.,Vertegaal A.C.,Nielsen M.L.
Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
Nat. Struct. Mol. Biol.
24
325-336
2017
526338
Kwan A.H.Y.,Gell D.A.,Verger A.,Crossley M.,Matthews J.M.,Mackay J.P.
Engineering a protein scaffold from a PHD finger.
Structure
11
803-813
2003
