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Sequence of INSR_MOUSE

EC Number:2.7.10.1

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
2.7.10.1
receptor protein-tyrosine kinase
P15208
Mus musculus
1372
155610
Swiss-Prot
Reaction
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Other sequences found for EC No. 2.7.10.1

General information:

Sequence
show sequence in fasta format
   0 MGFGRGCETT AVPLLVAVAA LLVGTAGHLY PGEVCPGMDI RNNLTRLHEL ENCSVIEGHL
  60 QILLMFKTRP EDFRDLSFPK LIMITDYLLL FRVYGLESLK DLFPNLTVIR GSRLFFNYAL
 120 VIFEMVHLKE LGLYNLMNIT RGSVRIEKNN ELCYLATIDW SRILDSVEDN YIVLNKDDNE
 180 ECGDVCPGTA KGKTNCPATV INGQFVERCW THSHCQKVCP TICKSHGCTA EGLCCHKECL
 240 GNCSEPDDPT KCVACRNFYL DGQCVETCPP PYYHFQDWRC VNFSFCQDLH FKCRNSRKPG
 300 CHQYVIHNNK CIPECPSGYT MNSSNLMCTP CLGPCPKVCQ ILEGEKTIDS VTSAQELRGC
 360 TVINGSLIIN IRGGNNLAAE LEANLGLIEE ISGFLKIRRS YALVSLSFFR KLHLIRGETL
 420 EIGNYSFYAL DNQNLRQLWD WSKHNLTITQ GKLFFHYNPK LCLSEIHKME EVSGTKGRQE
 480 RNDIALKTNG DQASCENELL KFSFIRTSFD KILLRWEPYW PPDFRDLLGF MLFYKEAPYQ
 540 NVTEFDGQDA CGSNSWTVVD IDPPQRSNDP KSQTPSHPGW LMRGLKPWTQ YAIFVKTLVT
 600 FSDERRTYGA KSDIIYVQTD ATNPSVPLDP ISVSNSSSQI ILKWKPPSDP NGNITHYLVY
 660 WERQAEDSEL FELDYCLKGL KLPSRTWSPP FESDDSQKHN QSEYDDSASE CCSCPKTDSQ
 720 ILKELEESSF RKTFEDYLHN VVFVPRPSRK RRSLEEVGNV TATTLTLPDF PNVSSTIVPT
 780 SQEEHRPFEK VVNKESLVIS GLRHFTGYRI ELQACNQDSP DERCSVAAYV SARTMPEAKA
 840 DDIVGPVTHE IFENNVVHLM WQEPKEPNGL IVLYEVSYRR YGDEELHLCV SRKHFALERG
 900 CRLRGLSPGN YSVRVRATSL AGNGSWTEPT YFYVTDYLDV PSNIAKIIIG PLIFVFLFSV
 960 VIGSIYLFLR KRQPDGPMGP LYASSNPEYL SASDVFPSSV YVPDEWEVPR EKITLLRELG
1020 QGSFGMVYEG NAKDIIKGEA ETRVAVKTVN ESASLRERIE FLNEASVMKG FTCHHVVRLL
1080 GVVSKGQPTL VVMELMAHGD LKSHLRSLRP DAENNPGRPP PTLQEMIQMT AEIADGMAYL
1140 NAKKFVHRDL AARNCMVAHD FTVKIGDFGM TRDIYETDYY RKGGKGLLPV RWMSPESLKD
1200 GVFTASSDMW SFGVVLWEIT SLAEQPYQGL SNEQVLKFVM DGGYLDPPDN CPERLTDLMR
1260 MCWQFNPKMR PTFLEIVNLL KDDLHPSFPE VSFFYSEENK APESEELEME FEDMENVPLD
1320 RSSHCQREEA GGREGGSSLS IKRTYDEHIP YTHMNGGKKN GRVLTLPRSN PS
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
48189
Flores-Riveros J.R.,Sibley E.,Kastelic T.,Lane M.D.
Substrate phosphorylation catalyzed by the insulin receptor tyrosine kinase. Kinetic correlation to autophosphorylation of specific sites in the beta subunit.
J. Biol. Chem.
264
21557-21572
1989
2557333
48190
Church D.M.,Goodstadt L.,Hillier L.W.,Zody M.C.,Goldstein S.,She X.,Bult C.J.,Agarwala R.,Cherry J.L.,DiCuccio M.,Hlavina W.,Kapustin Y.,Meric P.,Maglott D.,Birtle Z.,Marques A.C.,Graves T.,Zhou S.,Teague B.,Potamousis K.,Churas C.,Place M.,Herschleb J.,Runnheim R.,Forrest D.,Amos-Landgraf J.,Schwartz D.C.,Cheng Z.,Lindblad-Toh K.,Eichler E.E.,Ponting C.P.
Lineage-specific biology revealed by a finished genome assembly of the mouse.
PLoS Biol.
7
0-0
2009
19468303
48191
Sibley E.,Kastelic T.,Kelly T.J.,Lane M.D.
Characterization of the mouse insulin receptor gene promoter.
Proc. Natl. Acad. Sci. U.S.A.
86
9732-9736
1989
2602374
48192
Sawka-Verhelle D.,Tartare-Deckert S.,White M.F.,Van Obberghen E.
Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786.
J. Biol. Chem.
271
5980-5983
1996
8626379
48193
Ribon V.,Printen J.A.,Hoffman N.G.,Kay B.K.,Saltiel A.R.
A novel, multifunctional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes.
Mol. Cell. Biol.
18
872-879
1998
9447983
48194
Chaika O.V.,Chaika N.,Volle D.J.,Hayashi H.,Ebina Y.,Wang L.M.,Pierce J.H.,Lewis R.E.
Mutation of tyrosine 960 within the insulin receptor juxtamembrane domain impairs glucose transport but does not inhibit ligand-mediated phosphorylation of insulin receptor substrate-2 in 3T3-L1 adipocytes.
J. Biol. Chem.
274
12075-12080
1999
10207032
48195
Emanuelli B.,Peraldi P.,Filloux C.,Sawka-Verhelle D.,Hilton D.,Van Obberghen E.
SOCS-3 is an insulin-induced negative regulator of insulin signaling.
J. Biol. Chem.
275
15985-15991
2000
10821852
48196
Galic S.,Klingler-Hoffmann M.,Fodero-Tavoletti M.T.,Puryer M.A.,Meng T.C.,Tonks N.K.,Tiganis T.
Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP.
Mol. Cell. Biol.
23
2096-2108
2003
12612081
48197
Ueki K.,Kondo T.,Kahn C.R.
Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms.
Mol. Cell. Biol.
24
5434-5446
2004
15169905
48198
Gundry R.L.,Raginski K.,Tarasova Y.,Tchernyshyov I.,Bausch-Fluck D.,Elliott S.T.,Boheler K.R.,Van Eyk J.E.,Wollscheid B.
The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation.
Mol. Cell. Proteomics
8
2555-2569
2009
19656770
48199
Wollscheid B.,Bausch-Fluck D.,Henderson C.,O'Brien R.,Bibel M.,Schiess R.,Aebersold R.,Watts J.D.
Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.
Nat. Biotechnol.
27
378-386
2009
19349973
48200
Luan B.,Zhao J.,Wu H.,Duan B.,Shu G.,Wang X.,Li D.,Jia W.,Kang J.,Pei G.
Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance.
Nature
457
1146-1149
2009
19122674
48201
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
21183079
48202
Tseng L.T.,Lin C.L.,Tzen K.Y.,Chang S.C.,Chang M.F.
LMBD1 protein serves as a specific adaptor for insulin receptor internalization.
J. Biol. Chem.
288
32424-32432
2013
24078630
48203
Schmidt V.,Schulz N.,Yan X.,Schuermann A.,Kempa S.,Kern M.,Blueher M.,Poy M.N.,Olivecrona G.,Willnow T.E.
SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity.
J. Clin. Invest.
126
2706-2720
2016
27322061