EC Number   |
Protein Variants |
Reference |
|---|
   3.4.24.24 | more |
calreticulin-deficient null mice embryos show increased MMP-2 expression and activity, but unaltered TIMP-2 inhibitor levels, the embryos show defects in the heart and body wall, phenotype, overview |
683846 |
| 3.4.24.24 | more |
construction of MMP-2 truncation mutants overview, an MMP-2 mutant, with deleted hemopexin-like domain and three fibronectin-like type II domains, and native MMP-2 show similar affinities for APP-IP, chimeric proteases, consisting of various parts of the MMP-2 catalytic domain and those of MMP-7 or MMP-9, show that Ala88 and Gly94 in the non-prime side and Tyr145 and Thr146 in the prime side of the substrate-binding cleft of MMP-2 contribute separately to the selective inhibition bei APP-PI, mutational interaction analysis, overview |
683673 |
| 3.4.24.24 | more |
generation of transgenic C57BL/6 mice overexpressing human MMP2, phenotype, overview |
754619 |
| 3.4.24.24 | A404E |
inactive |
711216 |
| 3.4.24.24 | E404A |
no enzymic activity, competition with isolated collagen-binding domain and with matrix metalloproteinase MMP-9 binding to native and denatured type I collagen |
667516 |
| 3.4.24.24 | down |
peptide isoleucine-tryptophan (Ile-Trp) inhibits expression and activity of matrix metalloproteinase-2 in rat aorta |
754999 |
| 3.4.24.24 | E404A |
proteolytically inactive pro-MMP-2 mutant |
734182 |
| 3.4.24.24 | more |
recombinant collagen binding domain of enzyme, competitive inhibition of gelatin binding to intact enzyme by 73%, inhibition of enzyme-dependent cleavage of an 11 amino acid short protein fragment by less than 10% |
670119 |
| 3.4.24.24 | more |
recombinant enzyme lacking collagen-binding domain, does not block binding to gelatin of either enzyme mutant E404A or matrix metalloproteinase MMP-9 mutant E402A |
667516 |
| 3.4.24.24 | C102S |
site-directed mutagenesis |
734182 |
