EC Number   |
Protein Variants |
Reference |
|---|
    2.1.2.3 | H256A |
complete loss of activity, mutation lowers the thermostability |
756701 |
| 2.1.2.3 | H256A |
inactive |
756701 |
| 2.1.2.3 | K255A |
complete loss of activity, mutation lowers the thermostability |
756701 |
| 2.1.2.3 | K255A |
inactive |
756701 |
| 2.1.2.3 | K255R |
mutation reduces activity by 76%. Mutation increases the Tm by approximately 3°C |
756701 |
| 2.1.2.3 | more |
several site directed mutants created with mutations in the inosine monophosphate cyclohydrolase domain of the enzyme |
658026 |
| 2.1.2.3 | N415A |
decrease in AICAR transformylase activity as compared with wild-type SlugATIC, indicating it might also play essential role in substrate binding. Increase in the thermostability |
756701 |
| 2.1.2.3 | N415A |
the mutation results in decrease in enzyme activity as compared with wild type enzyme |
756701 |
| 2.1.2.3 | T116S |
AICAR transformylase/inosine monophosphate cyclohydrolase 346C>G polymorphism |
673127 |
