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EC Number
Protein Variants
Commentary
Reference
1.14.15.29
C429L
the modification affect neither the binding nor the catalytic properties of the enzyme
-
,
717344
1.14.15.29
W83Y
mutation to the corresponding residue of isoform CYP125A4. Mutation reduces the size of the binding pocket, reducing the ability to bind 7alpha-hydroxylated substrates
-
,
744344
1.14.15.29
Y83W
mutation to the corresponding residue of isoform CYP125A3. Mutation increases the size of the binding pocket, increasing the ability to bind 7alpha-hydroxylated substrates. Enzyme shows activity toward 4-cholesten-3-one, albeit with sigmoidal kinetics
-
,
744344
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