EC Number   |
IC50 Value |
IC50 Value Maximum |
Inhibitor |
Reference |
|---|
   3.1.4.35 | 0.00000006 |
- |
vardenafil |
mutant Y612F, pH 7.5, 30°C |
678243 |
| 3.1.4.35 | 0.00000007 |
- |
3-ethyl-5-[(3R)-3-methylpiperazin-1-yl]-N-(pyrimidin-4-yl)-1-[2-(2,2,2-trifluoroethoxy)ethyl]-1H-pyrazolo[4,3-d]pyrimidin-7-amine |
pH and temperature not specified in the publication |
711409 |
| 3.1.4.35 | 0.00000009 |
- |
3-ethyl-N-(4-fluorophenyl)-5-(piperazin-1-yl)-1-[2-(2,2,2-trifluoroethoxy)ethyl]-1H-pyrazolo[4,3-d]pyrimidin-7-amine |
pH and temperature not specified in the publication |
711409 |
| 3.1.4.35 | 0.000000091 |
- |
vardenafil |
IC50: 0.091 nM |
670330 |
| 3.1.4.35 | 0.00000012 |
- |
vardenafil |
wild-type, pH 7.5, 30°C |
678243 |
| 3.1.4.35 | 0.00000014 |
- |
3-methyl-5-[(3R)-3-methylpiperazin-1-yl]-N-(pyrimidin-4-yl)-1-[2-(2,2,2-trifluoroethoxy)ethyl]-1H-pyrazolo[4,3-d]pyrimidin-7-amine |
pH and temperature not specified in the publication |
711409 |
| 3.1.4.35 | 0.00000015 |
- |
3-ethyl-5-(piperazin-1-yl)-N-(pyrimidin-4-yl)-1-[2-(2,2,2-trifluoroethoxy)ethyl]-1H-pyrazolo[4,3-d]pyrimidin-7-amine |
pH and temperature not specified in the publication |
711409 |
| 3.1.4.35 | 0.00000018 |
- |
3-[4-(3-hydroxypropyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one |
pH and temperature not specified in the publication |
712700 |
| 3.1.4.35 | 0.0000002 |
- |
3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]-pyrazin-2(1H)-one |
pH and temperature not specified in the publication |
712700 |
| 3.1.4.35 | 0.0000002 |
- |
3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one |
pH and temperature not specified in the publication |
712700 |
