3.1.6.4 | modeling of structure and molecular docking against galactose-6-sulfate, N-acetylgalactosamine-6-sulfate, keratan sulfate, chondroitin-6-sulfate, and the artificial substrate 4-methylumbelliferyl-beta-D-galactopyranoside-6-sulfate. Amino acids involved in ligand interaction correlate with those observed in other human sulfatases, and mutations within the active cavity reduce affinity of all evaluated ligands |
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