EC Number |
Ki Value [mM] |
Ki Value maximum [mM] |
Inhibitor |
Reference |
---|
2.7.1.91 | 0.0000043 |
- |
PF-543 |
isoform SphK1, at pH 7.4 and 23°C |
760460 |
2.7.1.91 | 0.00002 |
- |
Amgen 82 |
isoform SphK2, pH and temperature not specified in the publication |
760267 |
2.7.1.91 | 0.00004 |
- |
1-[3-(3-dodecylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide |
isoform SphK1, pH and temperature not specified in the publication |
760268 |
2.7.1.91 | 0.000047 |
- |
(2S)-1-(4-[4-[3-(2-cyclohexylethyl)phenyl]-1,3-oxazol-2-yl]benzoyl)pyrrolidine-2-carboximidamide |
isoform SphK1, pH and temperature not specified in the publication |
760268 |
2.7.1.91 | 0.00007 |
- |
1-[3-(3-undecylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide |
isoform SphK1, pH and temperature not specified in the publication |
760268 |
2.7.1.91 | 0.000075 |
- |
(2S)-1-[3-[7-(cyclohexylmethoxy)heptyl]benzoyl]pyrrolidine-2-carboximidamide |
isoform SphK1, pH and temperature not specified in the publication |
760268 |
2.7.1.91 | 0.000089 |
- |
(2S)-2-[3-[3-(trifluoromethyl)-4-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]-1,2,4-oxadiazol-5-yl]pyrrolidine-1-carboximidamide |
isoform SphK2, at pH 8.0 and 25°C |
761036 |
2.7.1.91 | 0.000089 |
- |
(S)-2-(3-(3-(trifluoromethyl)-4-((4-(trifluoromethyl)-benzyl)oxy)phenyl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboximidamide |
isoform SphK2, at pH 8.0 and 25°C |
761682 |
2.7.1.91 | 0.000089 |
- |
SLM6071469 |
isoform SphK2, at pH 8.0 and 25°C |
761682 |
2.7.1.91 | 0.00009 |
- |
(2S)-2-([3-[4-([4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]amino)phenyl]-1,2,4-oxadiazol-5-yl]methyl)pyrrolidine-1-carboximidamide |
isoform SphK2, at pH 8.0 and 25°C |
761036 |