EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
5.3.3.1 | more |
identification of a putative 3beta-hydroxy-steroid dehydrogenase/DELTA5-DELTA4 isomerase pathway with the ability to handle both dehydroepiansdrosterone as well as C-17 side-chain containing compounds such as pregnenolone and 3beta-hydroxy-16alpha,17alpha-epoxypregn-5-en-20-one. 3beta-HSD/isomerase activity only occurs following lactonization of the steroidal ring-D. Presence of C-7 allylic hydroxylation, in either epimeric form, inhibits 3beta-HSD/isomerase activity. In Aspergillus tamarii, pregnenolone and 3beta-hydroxy-16alpha,17alpha-epoxypregn-5-en-20-one are metabolized solely through the putative 3beta-HSD/isomerase pathway |
Aspergillus tamarii |
? |
- |
? |
5.3.3.1 | more |
identification of a putative 3beta-hydroxy-steroid dehydrogenase/DELTA5-DELTA4 isomerase pathway with the ability to handle both dehydroepiansdrosterone as well as C-17 side-chain containing compounds such as pregnenolone and 3beta-hydroxy-16alpha,17alpha-epoxypregn-5-en-20-one. 3beta-HSD/isomerase activity only occurs following lactonization of the steroidal ring-D. Presence of C-7 allylic hydroxylation, in either epimeric form, inhibits 3beta-HSD/isomerase activity. In Aspergillus tamarii, pregnenolone and 3beta-hydroxy-16alpha,17alpha-epoxypregn-5-en-20-one are metabolized solely through the putative 3beta-HSD/isomerase pathway |
Aspergillus tamarii KITA |
? |
- |
? |
5.3.3.1 | DELTA5-pregnen-3,20-dione |
- |
Bos taurus |
? |
- |
? |
5.3.3.1 | pregn-5-ene-3,20-dione-17alpha-ol |
- |
Bos taurus |
17alpha-hydroxyprogesterone |
- |
? |
5.3.3.1 | 17beta-Hydroxy-5(10)-estren-3-one |
- |
Comamonas testosteroni |
? |
- |
? |
5.3.3.1 | 17beta-Hydroxy-5(10)-estren-3-one |
at 0.25% of the activity compared to 5-androstene-3,17-dione |
Comamonas testosteroni |
? |
- |
? |
5.3.3.1 | 5(10)-estrene-3,17-dione |
nonsticky substrate |
Comamonas testosteroni |
estr-4-en-3,17-dione |
- |
? |
5.3.3.1 | 5,10-Seco-19-norpregn-5-yne-3,10,20-trione |
i.e. pregnyne |
Comamonas testosteroni |
? |
- |
? |
5.3.3.1 | 5,10-Secoestr-5-yne-3,10,17-trione |
i.e. estryne |
Comamonas testosteroni |
? |
- |
? |
5.3.3.1 | 5-Androstene-3,17-dione |
- |
Comamonas testosteroni |
4-Androstene-3,17-dione |
- |
? |