EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.4.2.60 | more |
Thi4 is a suicidal enzyme undergoing only a single turnover |
Saccharomyces cerevisiae |
? |
- |
? |
2.4.2.60 | more |
mechanism starts with cleavage of the N-glycosyl bond of NAD followed by ring opening, tautomerization and loss of water. Reaction continues with imine formation, tautomerization, sulfide addition and cyclization. Elimination of two water molecules followed by a tautomerization completes the formation of the thiazole moiety |
Saccharomyces cerevisiae |
? |
- |
? |
2.4.2.60 | more |
mechanism starts with cleavage of the N-glycosyl bond of NAD followed by ring opening, tautomerization and loss of water. Reaction continues with imine formation, tautomerization, sulfide addition and cyclization. Elimination of two water molecules followed by a tautomerization completes the formation of the thiazole moiety |
Saccharomyces cerevisiae ATCC 204508 |
? |
- |
? |
2.4.2.60 | NAD+ + glycine + [ADP-thiazole synthase]-L-cysteine |
- |
Saccharomyces cerevisiae |
nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + [ADP-thiazole synthase]-dehydroalanine + 3 H2O |
- |
? |
2.4.2.60 | NAD+ + glycine + [ADP-thiazole synthase]-L-cysteine |
- |
Triticum aestivum |
nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + [ADP-thiazole synthase]-dehydroalanine + 3 H2O |
- |
? |
2.4.2.60 | NAD+ + glycine + [ADP-thiazole synthase]-L-cysteine |
- |
Hordeum vulgare |
nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + [ADP-thiazole synthase]-dehydroalanine + 3 H2O |
- |
? |
2.4.2.60 | NAD+ + glycine + [ADP-thiazole synthase]-L-cysteine |
- |
Arabidopsis thaliana |
nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + [ADP-thiazole synthase]-dehydroalanine + 3 H2O |
- |
? |
2.4.2.60 | NAD+ + glycine + [ADP-thiazole synthase]-L-cysteine |
- |
Avena sativa |
nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + [ADP-thiazole synthase]-dehydroalanine + 3 H2O |
- |
? |
2.4.2.60 | NAD+ + glycine + [ADP-thiazole synthase]-L-cysteine |
- |
Caladium bicolor |
nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + [ADP-thiazole synthase]-dehydroalanine + 3 H2O |
- |
? |