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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Show all pathways known for 2.4.1.131Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.1312 GDP-alpha-D-mannose + alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol - Saccharomyces cerevisiae 2 GDP + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol - ?
Show all pathways known for 2.4.1.131Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.1312 GDP-alpha-D-mannose + alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol - Saccharomyces cerevisiae ATCC 204508 2 GDP + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol - ?
Show all pathways known for 2.4.1.131Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.1312 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol - Oryctolagus cuniculus 2 UDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol - ?
Show all pathways known for 2.4.1.131Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.1312 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol - Saccharomyces cerevisiae 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol - ?
Show all pathways known for 2.4.1.131Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.1312 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol mannosyltransferase Alg11 carries out two consecutive alpha-1,2-mannosylation steps of the substrate Manalpha1,3-(Manalpha1,6)-Man-beta1,4-GlcNAc-beta1,4-GlcNAc-diphosphodolichol. Biosynthesis of asparagine-linked glycoproteins, which is assembled by the series of membrane-bound glycosyltransferases that comprise the dolichol pathway Saccharomyces cerevisiae 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol - ?
Show all pathways known for 2.4.1.131Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.1312 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol the biosynthesis of asparagine-linked glycans occurs in an evolutionarily conserved manner with the assembly of the unique lipid-linked oligosaccharide precursor Glc3Man9GlcNAc2-PPDo at the endoplasmic reticulum. The enzyme catalyzes the transfer of two alpha1,2-linked mannose residues from GDP-mannose to Man3GlcNAc2-PP-Dol and subsequently to Man4GlcNAc2-PP-Dol forming the Man5GlcNAc2-PP-Dol intermediate at the cytosolic side of the endoplasmic reticulum before flipping to the luminal side Saccharomyces cerevisiae 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol - ?
Show all pathways known for 2.4.1.131Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.1312 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol mannosyltransferase Alg11 carries out two consecutive alpha-1,2-mannosylation steps of the substrate Manalpha1,3-(Manalpha1,6)-Man-beta1,4-GlcNAc-beta1,4-GlcNAc-diphosphodolichol Saccharomyces cerevisiae 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol - ?
Show all pathways known for 2.4.1.131Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.131GDP-mannose + lipid-linked Manalpha(1-3)Manbeta-GlcNAcbeta-GlcNAc reaction via penta- and hexasaccharide intermediates to a lipid-linked heptasaccharide, presumably multiple mannosyltransferases involved Bos taurus GDP + lipid-linked Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)(Manalpha(1-6))Manbeta-GlcNAcbeta-GlcNAc - ?
Show all pathways known for 2.4.1.131Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.131GDP-mannose + oligosaccharide-lipid acceptor oligosaccharide portion: a mixture of trisaccharide and pentasaccharide, acceptor lipids are probably Manbeta-GlcNAc-GlcNAc-pyrophosphoryldolichol and Man2alpha-Manbeta-GlcNAc-GlcNAc-pyrophosphoryldolichol Sus scrofa GDP + alpha-mannosyl-1,2-oligosaccharide-lipid heptasaccharide-lipid as product, probably Man5GlcNAc2 as heptasaacharide ?
Show all pathways known for 2.4.1.131Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.131GDP-mannose + oligosaccharide-lipid acceptor oligosaccharide-P-P-lipid: major oligosaccharide component is Man2GlcNAc2 Oryctolagus cuniculus GDP + alpha-mannosyl-1,2-oligosaccharide-lipid penta-, hexa-, and heptasaccharide as oligosaccharide portion, formed by the stepwise addition of mannose to the growing oligosaccharide chain ?
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