EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.5.1.15 | 5,10-methylenetetrahydrofolate + NADP+ |
- |
Homo sapiens |
5,10-methenyltetrahydrofolate + NADPH + H+ |
? |
- |
1.5.1.15 | more |
MTHFD2 interacts with mitochondrial ETC complex III in mitochondria, mechanism |
Mus musculus |
? |
- |
- |
1.5.1.15 | more |
identification of the reaction product of MSMEG_6596 by LC-MS/MS |
Mycolicibacterium smegmatis |
? |
- |
- |
1.5.1.15 | more |
identification of the reaction product of MSMEG_6649 by LC-MS/MS |
Mycolicibacterium smegmatis |
? |
- |
- |
1.5.1.15 | more |
the reaction catalyzed by Escherichia coli MTHFR can be divided into a reductive half-reaction and an oxidative half-reaction, respectively, in which the FAD cofactor acts as an intermediate electron acceptor and donor. For enzyme assay, menadione is used as an alternate electron acceptor, MTHFR oxidizes NADH to NAD+, and the reaction can be monitored at 343 nm by the decrease in NADH absorbance |
Escherichia coli |
? |
- |
- |
1.5.1.15 | more |
identification of the reaction product of MSMEG_6596 by LC-MS/MS |
Mycolicibacterium smegmatis ATCC 700084 |
? |
- |
- |
1.5.1.15 | more |
identification of the reaction product of MSMEG_6649 by LC-MS/MS |
Mycolicibacterium smegmatis ATCC 700084 |
? |
- |
- |
1.5.1.15 | 5,10-methylenetetrahydrofolate + NAD+ |
- |
Mus musculus |
5,10-methenyltetrahydrofolate + NADH |
- |
? |
1.5.1.15 | 5,10-methylenetetrahydrofolate + NAD+ |
- |
Homo sapiens |
5,10-methenyltetrahydrofolate + NADH |
- |
? |
1.5.1.15 | 5,10-methylenetetrahydrofolate + NAD+ |
enzyme provides one-carbon units for purine synthesis during embryogenesis, metabolism overview |
Mus musculus |
5,10-methenyltetrahydrofolate + NADH |
- |
? |