EC Number   |
Substrates |
Organism  |
Products |
Reversibility |
|---|
   1.14.20.13 | (6S)-6beta-hydroxyhyoscyamine + 2-oxoglutarate + O2 |
- |
Anisodus acutangulus |
scopolamine + succinate + CO2 |
- |
? |
| 1.14.20.13 | (6S)-hydroxyhyoscyamine + 2-oxoglutarate + O2 |
- |
Anisodus acutangulus |
scopolamine + succinate + CO2 |
- |
? |
| 1.14.20.13 | (6S)-6beta-hydroxyhyoscyamine + 2-oxoglutarate + O2 |
- |
Anisodus tanguticus |
scopolamine + succinate + CO2 + H2O |
- |
? |
| 1.14.20.13 | more |
enzyme catalyzes both the hydroxylation of hyoscyamine, reaction of EC 1.14.11.11, and the epoxidation of 6beta-hydroxyhyoscyamine to generate scopolamine |
Anisodus tanguticus |
? |
- |
? |
| 1.14.20.13 | (6S)-6beta-hydroxyhyoscyamine + 2-oxoglutarate + O2 |
- |
Atropa belladonna |
scopolamine + succinate + CO2 |
- |
? |
| 1.14.20.13 | (6S)-6beta-hydroxyhyoscyamine + 2-oxoglutarate + O2 |
via 6,7-dehydrohyoscyamine or not, two possible pathways for the epoxidation in the biosynthesis of scopolamine, overview |
Atropa belladonna |
scopolamine + succinate + CO2 |
- |
? |
| 1.14.20.13 | 6,7-dehydrohyoscyamine + 2-oxoglutarate + O2 |
- |
Atropa belladonna |
? |
- |
? |
| 1.14.20.13 | 8-methyl-8-azabicyclo[3.2.1]octan-3-yl 2-(4-(dimethylamino)phenyl)acetate + 2-oxoglutarate + O2 |
- |
Atropa belladonna |
? |
- |
? |
| 1.14.20.13 | 8-methyl-8-azabicyclo[3.2.1]octan-3-yl benzoate + 2-oxoglutarate + O2 |
- |
Atropa belladonna |
? |
- |
? |
| 1.14.20.13 | more |
hyoscyamine 6beta-hydroxylase, a 2-oxoglutarate-dependent dioxygenase, converts L-hyoscyamine to its 6,7-epoxy derivative, scopolamine, in two sequential steps, the enzyme also catalyzes the reaaction of EC 1.14.11.11. 6,7-Dehydrohyoscyamine, a potential precursor for the last step of epoxidation, is an obligatory intermediate in the biosynthesis of scopolamine |
Atropa belladonna |
? |
- |
? |
