EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.14.11.16 | ankyrin repeat domain of endogenous Notch receptor L-asparagine + 2-oxoglutarate + O2 |
hydroxylation of highly conserved asparaginyl residues within the ankyrin repeat |
Homo sapiens |
ankyrin repeat domain of endogenous Notch receptor 3-hydroxy-L-asparagine + succinate + CO2 |
- |
? |
1.14.11.16 | ankyrin repeat domain of endogenous Notch receptor L-asparagine + 2-oxoglutarate + O2 |
hydroxylation of hyghly conserved asparaginyl residues within the ankyrin repeat |
Mus musculus |
ankyrin repeat domain of endogenous Notch receptor 3-hydroxy-L-asparagine + succinate + CO2 |
- |
? |
1.14.11.16 | ankyrin repeat domain protein |
a maximum of three ankyrin repeats enables ankyrin repeat domain proteins as a substrate |
Homo sapiens |
? |
- |
? |
1.14.11.16 | first epidermal growth factor-like domain-L-aspartate + 2-oxoglutarate + O2 |
- |
Bos taurus |
first epidermal growth factor-like domain-3-hydroxy-L-aspartate + succinate + CO2 |
- |
r |
1.14.11.16 | HIF (L-Asn803) + 2-oxoglutarate + O2 |
accepts HIF-1alpha and HIF-2-alpha as substrate, HIF mutant V802A exhibits 4fold lower substrate activity than native protein, no activity with N803A mutant |
Homo sapiens |
HIF (3-hydroxy-L-Asn803) + succinate + CO2 |
- |
? |
1.14.11.16 | HIF-1alpha peptide Asp788-Leu822 (L-Asn803) + 2-oxoglutarate + O2 |
much lower activity with peptides lacking residues 819-822, 807-822, and 815-822 |
Homo sapiens |
HIF-1alpha peptide Asp788-Leu822 (3-hydroxy-L-Asn803) + succinate + CO2 |
- |
? |
1.14.11.16 | HIF-1alpha peptide Asp788-Leu822 (L-asparagine803) + 2-oxoglutarate + O2 |
- |
Homo sapiens |
? |
- |
r |
1.14.11.16 | more |
overexpression may be associated with malignant transformation |
Mus musculus |
? |
- |
? |
1.14.11.16 | more |
overexpression may be associated with malignant transformation |
Homo sapiens |
? |
- |
? |
1.14.11.16 | more |
the enzyme hydroxylates epidermal growth factor-like domains in transformation-associated proteins |
Homo sapiens |
? |
- |
? |