EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   4.2.1.127 | more |
the bifunctional linalool dehydratase isomerase (LinD) catalyzes the isomerization of geraniol to linalool, EC 5.4.4.4, and likewise the dehydration of linalool to myrcene, EC 4.2.1.127. Substrate binding structure, overview |
Castellaniella defragrans |
? |
- |
? |
| 4.2.1.127 | more |
a bifunctional linalool dehydratase/isomerase that exhibits dehydratase activity, Ec 4.2.1.127, and isomerase activity, EC 5.4.4.4. The enzyme catalyzes the reversible hydration of beta-myrcene to linalool and its isomerization to geraniol. No activity is measured with nerol or citronellol alone. Linalool isomerase activity drops to approx. 50% in the presence of nerol. Activity in the presence of citronellol and geraniol is barely detectable. The enzyme is regioselective and seems to bind nerol with a similar affinity as geraniol, whereas citronellol which lacks the C2-C3 double bond is stronger bound than geraniol. Stereoselectivity analysis |
Thauera linaloolentis 47Lol |
? |
- |
? |
| 4.2.1.127 | more |
the bifunctional linalool dehydratase isomerase (LinD) catalyzes the isomerization of geraniol to linalool, EC 5.4.4.4, and likewise the dehydration of linalool to myrcene, EC 4.2.1.127. No activity with alpha-ocimene and beta-ocimene as well as citronellol and nerol. LinD accepts a broad variety of elongated and truncated aliphatic and even aromatic tertiary alcohols (C5-C15) providing chiral dehydration products with selectivity factors of up to 200. Substrates lacking the signature motif are not accepted by LinD |
Castellaniella defragrans 65Phen |
? |
- |
? |
| 4.2.1.127 | more |
the bifunctional linalool dehydratase isomerase (LinD) catalyzes the isomerization of geraniol to linalool, EC 5.4.4.4, and likewise the dehydration of linalool to myrcene, EC 4.2.1.127. Substrate binding structure, overview |
Castellaniella defragrans 65Phen |
? |
- |
? |
| 4.2.1.127 | more |
neither the monoterpenes alpha- and beta-ocimene nor the monoterpenoids citronellol and nerol are transformed |
Castellaniella defragrans 65Phen |
? |
- |
? |
| 4.2.1.127 | more |
the thermodynamically favoured direction is the isomerization of geraniol to linalool and the dehydration reaction to beta-myrcene |
Castellaniella defragrans 65Phen |
? |
- |
? |
| 4.2.1.127 | myrcene + H2O |
degradation of myrcene |
Castellaniella defragrans |
linalool |
- |
r |
| 4.2.1.127 | myrcene + H2O |
degradation of myrcene |
Castellaniella defragrans 65Phen |
linalool |
- |
r |
