EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.14.11.27 | [histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2 |
predicted site-specificity from phylogenetic analysis |
Plasmodium falciparum |
[histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2 |
- |
? |
1.14.11.27 | [histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2 |
removal of histone H3 Lys36 dimethylation is coupled to histone H2A monoubiquitinylation, overview |
Drosophila melanogaster |
[histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2 |
- |
? |
1.14.11.27 | [histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2 |
the effect of Jhdm1b on cell proliferation and cellular senescence is mediated through de-repression of p15Ink4b as loss of p15Ink4b function rescues cell proliferation defects in Jhdm1b knockdown cells |
Mus musculus |
[histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2 |
- |
? |
1.14.11.27 | [histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2 |
predicted site-specificity from phylogenetic analysis |
Plasmodium falciparum |
[histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2 |
- |
? |
1.14.11.27 | [histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 |
predicted site-specificity from phylogenetic analysis |
Plasmodium falciparum |
[histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2 |
- |
? |
1.14.11.27 | [histone H3]-N6-methyl-L-lysine 36 + 2-oxoglutarate + O2 |
- |
Mus musculus |
[histone H3]-L-lysine 36 + succinate + formaldehyde + CO2 |
- |
? |
1.14.11.27 | [histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2 |
predicted site-specificity from phylogenetic analysis |
Plasmodium falciparum |
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2 |
- |
? |