EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
    1.1.1.270 | more |
enzyme of plant sterol biosynthesis, involved in sterol-4 demethylation, invoves the removal of two methyl groups at C4 |
Zea mays |
? |
- |
? |
| 1.1.1.270 | more |
HSD17B7 participates in postsqualene cholesterol biosynthesis |
Mus musculus |
? |
- |
? |
| 1.1.1.270 | more |
HSD17B7 participates in postsqualene cholesterol biosynthesis, HSD17B7 is a novel candidate for inborn errors of cholesterol metabolism |
Homo sapiens |
? |
- |
? |
| 1.1.1.270 | more |
the enzyme is also involved in synthesis of estradiol and estrone, neurosteroids paly a role in brain develkopment and in stimulation and control of song function |
Taeniopygia guttata |
? |
- |
? |
| 1.1.1.270 | more |
tibolone is used to treat climacteric symptoms and prevent osteoporosis, it exerts tissue-selective effects via site-specific metabolism into 3alpha- and 3beta-hydroxymetabolites and a DELTA4-isomer, In Hep-G2 cell cytosol and intact cells tibolone is exclusively reduced to 3beta-hydroxytibolone, tibolone metabolism in human liver is catalyzed by 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four isoforms of the aldo-keto reductase (AKR)1C subfamily, overview |
Homo sapiens |
? |
- |
? |
| 1.1.1.270 | more |
AKR1C1 is a cytosolic hydroxysteroid dehydrogenase, that reduces 3-ketosteroids and 20-ketosteroids, overview, molecular docking simulations with generation of docking targets, overview |
Homo sapiens |
? |
- |
? |
| 1.1.1.270 | more |
comparison of substrate specificity and enantioselectivity of AKR1C isozymes, overview |
Homo sapiens |
? |
- |
? |
| 1.1.1.270 | more |
the enzyme, termed AKR1B19, acts not only as a reductase for reactive carbonyl compounds derived from lipid peroxidation like AR-like proteins of other species, but also as a superior reductive 3beta-HSD for 3-keto-5alpha/beta-dihydro-C19/C21/C24-steroids |
Oryctolagus cuniculus |
? |
- |
? |
| 1.1.1.270 | more |
both isoforms of the enzyme catalyze the conversion of 3beta-hydroxy-5-ene-steroids (dehydroepiandrosterone, 17alpha-hydroxypregnenolone, pregnenolone) to 3-oxo-4-ene-steroids (androstenedione, 17alpha-hydroxyprogestrone, progesterone) on a single, dimeric protein containing both enzyme activities |
Homo sapiens |
? |
- |
? |
| 1.1.1.270 | more |
substrate for 3-ketoreductase in the first sterol C-4 demethylation cycle is 4alpha-methylfecosterone, whereas that for the second C-4 demethylation cycle is fecosterone |
Botrytis cinerea |
? |
- |
? |
