EC Number |
General Information |
Reference |
---|
6.3.5.1 | evolution |
most residues lining the ATP-binding site are conserved among the glutamine-dependent NAD+ synthetases, whereas residues not conserved, such as Leu399 andGly366, interact with the adenine ring and the adenylyl ribose with the backbone oxygen and nitrogen |
-, 726904 |
6.3.5.1 | malfunction |
a homolog of the human SIRT6-like gene, SRT2, is upregulated in the NAD+ synthase mutant, which shows a longer vegetative life span than wild-type cells |
716662 |
6.3.5.1 | malfunction |
nadE is dispensable when the nondeamidating salvage pathway functions as the only route of NAD biogenesis |
715566 |
6.3.5.1 | metabolism |
due to the presence of an additional glutamine transferase domain, abNadE can efficiently utilize l-glutamine (as well as ammonia) for the amidation of NAD precursor |
715566 |
6.3.5.1 | more |
the enzyme contains glutaminase and synthetase active sites, structures and ligand binding, overview. The ATP-binding site is located in a deep cleft formed solely by a single subunit next to the nicotinic acidadenine dinucleotide-binding site |
-, 726904 |
6.3.5.1 | physiological function |
nadE, encoding glutamine-dependent NAD synthetase, is dispensable when the nondeamidating salvage pathway of nicotinamide salvage/recycling functions as the only route of NAD biogenesis |
715566 |