EC Number   |
General Information |
Reference |
|---|
    3.5.2.5 | malfunction |
allantoin accumulation is mediated by allantoinase downregulation. Knockout, knockdown, and stress-inducible mutants of AtALN reveal that allantoin accumulation is essential for salt stress tolerance, phenotypes, overview |
-, 758020 |
| 3.5.2.5 | malfunction |
ALN-overexpressing (ALNox) lines. in ALNox lines the ALN gene expression increase leads to increased enzyme activity and suppressed allantoin accumulation. Therefore, ALNox Arabidopsis thaliana lines exhibit the opposite phenotype in comparison with aln-3 mutants, namely sensitivity sto abiotic stress. The aln-3 enzyme-deficient mutant lines exhibit increased Cd tolerance |
-, 758067 |
| 3.5.2.5 | malfunction |
T-DNA insertions in allantoinase cause the constitutive accumulation of allantoin resulting in plant resistance to different abiotic stresses such as drought, salinity (NaCl), and heavy metal cadmium toxicity. High concentration of allantoin in allantoinase-negative mutant (aln-3) leaves alleviates cadmium toxicity via inducing antioxidant mechanisms in these plants. In contrast with wild-type leaves, high levels of Cd in Col-0 roots reduces transcript abundance of uricase, leading to a significant decline in allantoin level of treated roots at 1000 and 1500 mM CdCl2, molecular mechanism underlying allantoin content of root in response to Cd stress, overview. Root elongation is reduced in Cd-treated wild-type but not enzyme-deficient plants. Despite higher Cd content, aln-3 roots contain lower reactive oxygen species concentrations. Antioxidant enzymes are more active in aln-3 roots following Cd treatment |
-, 758060 |
| 3.5.2.5 | metabolism |
allantoin treatment of wild-type Col-0 seeds increases superoxide dismutase activity causing an enhanced seed germination and seedling growth following Cd exposure. Allantoinase-overexpressing (ALNox) lines with lower levels of allantoin exhibit more susceptibility to Cd treatment than wild-type Arabidopsis thaliana, implying that there is a positive correlation between allantoin concentration and Cd resistance in plants. The potential regulatory function of allantoin does not require abscisic acid (ABA) at germination but may be ABA-dependent at later stages of seedling growth, suggesting a potential crosstalk between allantoin-mediated stress response and ABA signalling pathway in plants. Protective role for allantoin at early stages of seedling growth. Increased allantoin concentration (both in vivo and in vitro) causes Cd-tolerance in plants |
-, 758067 |
| 3.5.2.5 | metabolism |
Cd tolerance and the role allantoin plays in plant abiotic stress response are linked |
-, 758060 |
| 3.5.2.5 | metabolism |
expression of genes for allantoin synthesis and degradation are oppositely regulated during salt stress. The AtALN promoter activity is present in specific plant tissues during plant development and is strongly repressed by salt stress. Allantoin transport mediated by ureide permease 5 (AtUPS5) is an important event in salt stress alleviation |
-, 758020 |
| 3.5.2.5 | metabolism |
the rice genome is predicted to contain singles gene for each of the allantoin-catabolic enzymes: allantoinase (OsALN), allantoate amidohydrolase (OsAAH), ureidoglycine aminohydrolase (OsUGlyAH), and ureidoglycolate amidohydrolase (OsUAH), analysis of transcriptional regulation of these allantoin-catabolic genes in response to the N status, quantitative expression analysis, and production of allantoin-derived metabolites in response to changes in exogenous N status, overview |
756836 |
| 3.5.2.5 | more |
residue Ser292 is likely implicated in the binding of the allantoin ring through the carbonyl group of the polypeptide main chain, which is the common mechanism observed in other members of the amidohydrolase family. Modeling and docking studies |
-, 733438 |
| 3.5.2.5 | physiological function |
allantoin accumulation is essential for salt stress tolerance. The regulation of the enzyme-encoding gene is mainly responsible for allantoin accumulation observed under salt stress. Possible roles of allantoin as a protectant compound in oxidative events or signaling, overview |
-, 758020 |
| 3.5.2.5 | physiological function |
allantoin is used as an N source in rice plants, allantoin-derived metabolites following the up-regulation of OsALN and OsAAH expression, under N starvation conditions |
756836 |
