EC Number   |
General Information |
Reference |
|---|
   3.4.16.5 | malfunction |
mice with a double CathA/Scpep1 deficiency (DD mice) demonstrate hypertension, increased ET-1-induced vasoconstriction and prolonged half-life of circulating ET-1 as compared to both wild-type animals and those with single CathA or Scpep1 deficiencies |
732667 |
| 3.4.16.5 | physiological function |
Btn1p is required for vacuole protein sorting of Cpy1p |
704781 |
| 3.4.16.5 | physiological function |
cathepsin A (cathA) is involved in spermatophore wall rupture |
732289 |
| 3.4.16.5 | physiological function |
cathepsin A is involved in the C-terminal fine-tuning of antigenic T cell epitopes in human antigen-presenting cells |
703982 |
| 3.4.16.5 | physiological function |
CtsA has potentially important roles in innate immune responses of turbot. Recombinant CTSA binds lipopolysaccharide with high affinity, and lipoteichoic acid and peptidoglycan with relatively low affinity |
753612 |
| 3.4.16.5 | physiological function |
mouse model of cardiomyocyte-specific human CTSA overexpression. CTSA strongly impairs the balance of the proteolytic system by upregulating proteases such as cathepsin B, cathepsin D, and cathepsin Z while downregulating numerous protease inhibitors. Cardiomyocyte-specific human CTSA overexpression strongly reduces the levels of numerous antioxidative stress proteins, i.e., peroxiredoxins and protein deglycase DJ-1. In vitro, using cultured rat cardiomyocytes, ectopic overexpression of CTSA results in accumulation of reactive oxygen species |
754487 |
| 3.4.16.5 | physiological function |
PNGase releases N-glycans from the mutant during the endoplasmic reticulum-associated degradation process in vivo. A major endoproteolytic reaction on the mutant appears to occur between amino acid 400 and 404 |
752800 |
| 3.4.16.5 | physiological function |
SCEP1 complements CathA action towards endothelin ET-1 |
732667 |
| 3.4.16.5 | physiological function |
Scpep1 and CathA together participate in the control of endothelin ET-1 regulation of vascular tone and hemodynamics |
732667 |
| 3.4.16.5 | physiological function |
Scpep1-deficient mice are viable and fertile, and do not exhibit either lysosomal storage or reduced lysosomal serine carboxypeptidase activity |
708470 |
