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EC Number General Information Commentary Reference
Show all pathways known for 1.8.1.14Display the word mapDisplay the reaction diagram Show all sequences 1.8.1.14malfunction spirochetes lacking CoADR exhibit a growth defect under both aerobic and anaerobic conditions. Enzyme loss affects survival of spirochete in fed, but not flat tick nymphs -, 726003
Show all pathways known for 1.8.1.14Display the word mapDisplay the reaction diagram Show all sequences 1.8.1.14physiological function the enzyme is not essential for S0 respiration in Pyrococcus but appears to participate in oxidative defense in the presence of elemental sulfur 724377
Show all pathways known for 1.8.1.14Display the word mapDisplay the reaction diagram Show all sequences 1.8.1.14physiological function the enzyme of Borrelia burgdorferi is necessary to maintain optimal redox ratios for CoA/CoA-disulfide and NAD+/NADH during periods of rapid replication throughout the enzootic cycle, to support thiol-disulfide homeostasis, and to indirectly protect the spirochete against peroxide-mediated membrane damage. The enzyme is also required for infectivity in mice -, 726003
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